Vascular and perivascular nitric oxide release and transport: Biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)

Free Radical Biology and Medicine

Volumn 42, Issue 6, 2007, Pages 811-822

  Chen, Kejing ^a   Popel, Aleksander S ^a  

^a Johns Hopkins University   (United States)

Author keywords

Computational model; Mass balance analysis; Reaction kinetics; Theoretical model

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; EFFECTOR CELL; ENZYME RELEASE; ENZYME SUBUNIT; GEOMETRY; MAST CELL; MATHEMATICAL COMPUTING; MICROVASCULATURE; NERVE FIBER; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARACRINE SIGNALING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE DISTRIBUTION;

ANIMALS; CATALYSIS; DIFFUSION; ENDOTHELIUM, VASCULAR; HUMANS; KINETICS; MAST CELLS; MICROCIRCULATION; MODELS, THEORETICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; SOFTWARE; SUBSTRATE SPECIFICITY;

EID: 33847233296     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.12.007     Document Type: Article

References (55)

1. Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
2. Lancaster Jr. J.R. Simulation of the diffusion and reaction of endogenously produced nitric oxide. Proc. Natl. Acad. Sci. USA 91 (1994) 8137-8141
3. Huang A., Sun D., Shesely E.G., Levee E.M., Koller A., and Kaley G. Neuronal NOS-dependent dilation to flow in coronary arteries of male eNOS-KO mice. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H429-H436
4. Kashiwagi S., Kajimura M., Yoshimura Y., and Suematsu M. Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ. Res. 91 (2002) e55-e64
5. Talukder M.A., Fujiki T., Morikawa K., Motoishi M., Kubota H., Morishita T., Tsutsui M., Takeshita A., and Shimokawa H. Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice. J. Cardiovasc. Pharmacol. 44 (2004) 437-445
6. Kavdia M., and Popel A.S. Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure. J. Appl. Physiol. 97 (2004) 293-301
7. 2 in the microcirculation: a mathematical analysis. Microvasc. Res. 68 (2004) 38-50
8. Vaughn M.W., Kuo L., and Liao J.C. Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model. Am. J. Physiol. 274 (1998) H2163-H2176
9. Bidri M., Feger F., Varadaradjalou S., Ben Hamouda N., Guillosson J.J., and Arock M. Mast cells as a source and target for nitric oxide. Int. Immunopharmacol. 1 (2001) 1543-1558
10. Brown L.A., Key B.J., and Lovick T.A. Fluorescent imaging of nitric oxide production in neuronal varicosities associated with intraparenchymal arterioles in rat hippocampal slices. Neurosci. Lett. 294 (2000) 9-12
11. Chen K., and Popel A.S. Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. Free Radic. Biol. Med. 41 (2006) 668-680
12. Santolini J., Adak S., Curran C.M., and Stuehr D.J. A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase. J. Biol. Chem. 276 (2001) 1233-1243
13. Santolini J., Meade A.L., and Stuehr D.J. Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III. J. Biol. Chem. 276 (2001) 48887-48898
14. Gorren A.C., Schmidt K., and Mayer B. Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase. Biochemistry 41 (2002) 7819-7829
15. Ost T.W., and Daff S. Thermodynamic and kinetic analysis of the nitrosyl, carbonyl, and dioxy heme complexes of neuronal nitric-oxide synthase. The roles of substrate and tetrahydrobiopterin in oxygen activation. J. Biol. Chem. 280 (2005) 965-973
16. Wehling M., Stull J.T., McCabe T.J., and Tidball J.G. Sparing of mdx extraocular muscles from dystrophic pathology is not attributable to normalized concentration or distribution of neuronal nitric oxide synthase. Neuromuscul. Disord. 8 (1998) 22-29
17. Arnal J.F., Clamens S., Pechet C., Negre-Salvayre A., Allera C., Girolami J.P., Salvayre R., and Bayard F. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc. Natl. Acad. Sci. USA 93 (1996) 4108-4113
18. Wu G., and Morris Jr. S.M. Arginine metabolism: nitric oxide and beyond. Biochem. J. 336 Pt 1 (1998) 1-17
19. Schulman E.S., Kagey-Sobotka A., MacGlashan Jr. D.W., Adkinson Jr. N.F., Peters S.P., Schleimer R.P., and Lichtenstein L.M. Heterogeneity of human mast cells. J. Immunol. 131 (1983) 1936-1941
20. 2 carriers. Microvasc. Res. 66 (2003) 49-58
21. Singel D.J., and Stamler J.S. Blood traffic control. Nature 430 (2004) 297
22. Gladwin M.T., Schechter A.N., Kim-Shapiro D.B., Patel R.P., Hogg N., Shiva S., Cannon III R.O., Kelm M., Wink D.A., Espey M.G., Oldfield E.H., Pluta R.M., Freeman B.A., Lancaster Jr. J.R., Feelisch M., and Lundberg J.O. The emerging biology of the nitrite anion. Nat. Chem. Biol. 1 (2005) 308-314
23. Lewis R.S., and Deen W.M. Kinetics of the reaction of nitric oxide with oxygen in aqueous solutions. Chem. Res. Toxicol. 7 (1994) 568-574
24. 2. Proc. Natl. Acad. Sci. USA 98 (2001) 355-360
25. Gardner P.R., Martin L.A., Hall D., and Gardner A.M. Dioxygen-dependent metabolism of nitric oxide in mammalian cells. Free Radic. Biol. Med. 31 (2001) 191-204
26. Elayan I.M., Axley M.J., Prasad P.V., Ahlers S.T., and Auker C.R. Effect of hyperbaric oxygen treatment on nitric oxide and oxygen free radicals in rat brain. J. Neurophysiol. 83 (2000) 2022-2029
27. Stuehr D.J., Santolini J., Wang Z.Q., Wei C.C., and Adak S. Update on mechanism and catalytic regulation in the NO synthases. J. Biol. Chem. 279 (2004) 36167-36170
28. Gladwin M.T. Hemoglobin as a nitrite reductase regulating red cell-dependent hypoxic vasodilation. Am. J. Respir. Cell Mol. Biol. 32 (2005) 363-366
29. Condorelli P., and George S.C. In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis. Biophys. J. 80 (2001) 2110-2119
30. Kollau A., Hofer A., Russwurm M., Koesling D., Keung W.M., Schmidt K., Brunner F., and Mayer B. Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. Biochem. J. 385 (2005) 769-777
31. Stone J.R., and Marletta M.A. Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. Biochemistry 35 (1996) 1093-1099
32. Tsai A.G., Acero C., Nance P.R., Cabrales P., Frangos J.A., Buerk D.G., and Intaglietta M. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am.J. Physiol. Heart Circ. Physiol. 288 (2005) H1730-H1739
33. Vukosavljevic N., Jaron D., Barbee K.A., and Buerk D.G. Quantifying the L-arginine paradox in vivo. Microvasc. Res. 71 (2006) 48-54
34. Zani B.G., and Bohlen H.G. Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H1381-H1390
35. Buerk D.G., Lamkin-Kennard K., and Jaron D. Modeling the influence of superoxide dismutase on superoxide and nitric oxide interactions, including reversible inhibition of oxygen consumption. Free Radic. Biol. Med. 34 (2003) 1488-1503
36. Malinski T., Taha Z., Grunfeld S., Patton S., Kapturczak M., and Tomboulian P. Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors. Biochem. Biophys. Res. Commun. 193 (1993) 1076-1082
37. Suematsu M., Suganuma K., and Kashiwagi S. Mechanistic probing of gaseous signal transduction in microcirculation. Antioxid. Redox Signal. 5 (2003) 485-492
38. Allen B.W., and Piantadosi C.A. How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H1507-H1512
39. Robinson J.M., and Lancaster Jr. J.R. Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide: mechanism(s) and physiologic versus pathophysiologic relevance. Am. J. Respir. Cell Mol. Biol. 32 (2005) 257-261
40. Kleinbongard P., Schulz R., Rassaf T., Lauer T., Dejam A., Jax T., Kumara I., Gharini P., Kabanova S., Ozuyaman B., Schnurch H.G., Godecke A., Weber A.A., Robenek M., Robenek H., Bloch W., Rosen P., and Kelm M. Red blood cells express a functional endothelial nitric oxide synthase. Blood 107 (2006) 2943-2951
41. Lacza Z., Snipes J.A., Zhang J., Horvath E.M., Figueroa J.P., Szabo C., and Busija D.W. Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS. Free Radic. Biol. Med. 35 (2003) 1217-1228
42. Thom S.R., and Buerk D.G. Nitric oxide synthesis in brain is stimulated by oxygen. Exp. Med. Biol. 510 (2003) 133-137
43. 2 increases nitric oxide release from endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H507-H515
44. Chu A., Chambers D.E., Lin C.C., Kuehl W.D., Palmer R.M., Moncada S., and Cobb F.R. Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J. Clin. Invest. 87 (1991) 1964-1968
45. Rees D.D., Palmer R.M., Hodson H.F., and Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br. J. Pharmacol. 96 (1989) 418-424
46. Panza J.A., Casino P.R., Kilcoyne C.M., and Quyyumi A.A. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 87 (1993) 1468-1474
47. Kimura C., Oike M., Ohnaka K., Nose Y., and Ito Y. Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells: a comparative study. J. Physiol. 554 (2004) 721-730
48. de Wit C., Jahrbeck B., Schafer C., Bolz S.S., and Pohl U. Nitric oxide opposes myogenic pressure responses predominantly in large arterioles in vivo. Hypertension 31 (1998) 787-794
49. Kim M.H., Harris N.R., Korzick D.H., and Tarbell J.M. Control of the arteriolar myogenic response by transvascular fluid filtration. Microvasc. Res. 68 (2004) 30-37
50. Nellore K., and Harris N.R. Nitric oxide measurements in rat mesentery reveal disrupted venulo-arteriolar communication in diabetes. Microcirculation 11 (2004) 415-423
51. Stamler J.S., Jaraki O., Osborne J., Simon D.I., Keaney J., Vita J., Singel D., Valeri C.R., and Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc. Natl. Acad. Sci. USA 89 (1992) 7674-7677
52. 2 transport. J. Appl. Physiol. 100 (2006) 482-492
53. Rengasamy A., and Johns R.A. Determination of Km for oxygen of nitric oxide synthase isoforms. J. Pharmacol. Exp. Ther. 276 (1996) 30-33
54. Tsai A.G., Cabrales P., Hangai-Hoger N., and Intaglietta M. Oxygen distribution and respiration by the microcirculation. Antioxid. Redox Signal. 6 (2004) 1011-1018
55. Mansuy D., and Boucher J.L. Alternative nitric oxide-producing substrates for NO synthases. Free Radic. Biol. Med. 37 (2004) 1105-1121