Activating water: Efficient intramolecular general base catalysis of the hydrolysis of a phosphate triester

Chemistry - A European Journal

Volumn 15, Issue 34, 2009, Pages 8475-8479

  Kirby, Anthony J ^a   Medeiros, Michelle ^b   Oliveira, Pedro S M ^b   Brandão, Tiago A S ^b   Nome, Faruk ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Bioorganic chemistry; Enzyme catalysis; Hydrolysis; Intramolecular catalysis; Phosphate transfer

Indexed keywords

BIOORGANIC CHEMISTRY; ENZYME ACTIVE SITES; ENZYME CATALYSIS; HYDROLYSIS REACTION; INTRAMOLECULAR CATALYSIS; INTRAMOLECULAR GENERAL BASE CATALYSIS; PHOSPHATE TRANSFER; POSSIBLE SOLUTIONS; WATER MOLECULE;

BIOCHEMISTRY; ENZYMES; HYDROLYSIS; MOLECULES;

CATALYSIS;

ESTER; PHOSPHATE; WATER;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; HYDROLYSIS; KINETICS; STEREOISOMERISM; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESTERS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; PHOSPHATES; STEREOISOMERISM; THERMODYNAMICS; WATER;

EID: 69249155264     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200901096     Document Type: Article

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