RNA-dependent RNA polymerase of hepatitis C virus: Study on inhibition by α,γ-diketo acid derivatives

Biochemistry (Moscow)

Volumn 74, Issue 8, 2009, Pages 834-841

  Kozlov, M V ^a   Polyakov, K M ^a   Filippova, S E ^a   Evstifeev, V V ^a   Lyudva, G S ^a   Kochetkov, S N ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Hepatitis C virus; Inhibition mechanism; Molecular modeling; RNA dependent RNA polymerase; , diketo acid derivatives

Indexed keywords

BINDING ENERGY; ENZYMES; METAL IONS; MOLECULAR MODELING; VIRUSES;

ACTIVE CENTER; DIKETO ACIDS; ENZYME-INHIBITOR COMPLEX; HEPATITIS C VIRUS; INHIBITION MECHANISMS; MAGNESIUM IONS; PHOSPHODIESTER BONDS; RNA-DEPENDENT RNA POLYMERASE;

RNA;

HEPATITIS C VIRUS;

2,4 DIOXO 4 PHENYLBUTANOIC ACID; 2,4-DIOXO-4-PHENYLBUTANOIC ACID; AMINOBUTYRIC ACID DERIVATIVE; ENZYME INHIBITOR; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ARTICLE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HEPATITIS C VIRUS; KINETICS; METABOLISM; SYNTHESIS;

AMINOBUTYRIC ACIDS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HEPACIVIRUS; KINETICS; RNA REPLICASE; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 69249153331     PISSN: 00062979     EISSN: 16083040     Source Type: Journal    
DOI: 10.1134/S0006297909080033     Document Type: Article

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