Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications

Journal of Hematology and Oncology

Volumn 2, Issue , 2009, Pages

  Han, Shuhong ^a   Huang, Yuju ^b   Liang, Yin ^b   Ho, Yuchin ^b   Wang, Yichen ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b Vectorite Biomedica Inc   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; GAMMA INTERFERON; LATENT MEMBRANE PROTEIN 2; LATENT MEMBRANE PROTEIN 2A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG; VIRUS ANTIGEN; ANTIGEN; EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; EPITOPE; MATRIX PROTEIN; PEPTIDE FRAGMENT;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DENDRITIC CELL; EFFECTOR CELL; EPSTEIN BARR VIRUS; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LYMPHOBLASTOID CELL; LYMPHOPROLIFERATIVE DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; CELL CULTURE; CELL SEPARATION; CHEMISTRY; CULTURE TECHNIQUE; EVALUATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; T LYMPHOCYTE; TRANSPLANTATION;

ANTIGENS; ANTIGENS, CD137; CELL CULTURE TECHNIQUES; CELL SEPARATION; CELLS, CULTURED; EPITOPES; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; PEPTIDE FRAGMENTS; PHENOTYPE; T-LYMPHOCYTES; VIRAL MATRIX PROTEINS;

EID: 69249149276     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-2-34     Document Type: Article

References (48)

1. Principles for adoptive T cell therapy of human viral diseases. SR Riddell PD Greenberg, Annu Rev Immunol 1995 13 545 586 10.1146/annurev.iy.13. 040195.002553 7612234
2. Adoptive cellular immunotherapy for viral diseases. Y Fujita CM Rooney HE Heslop, Bone Marrow Transplant 2008 41 193 198 10.1038/sj.bmt.1705906 17982497 (Pubitemid 351188917)
3. Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. EB Papadopoulos M Ladanyi D Emanuel S Mackinnon F Boulad MH Carabasi H Castro-Malaspina BH Childs AP Gillio TN Small JW Young NA Kernan RJ O'Reilly, N Engl J Med 1994 330 1185 1191 10.1056/NEJM199404283301703 8093146 (Pubitemid 24121987)
4. Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts. RJ O'Reilly TN Small E Papadopoulos K Lucas J Lacerda L Koulova, Immunol Rev 1997 157 195 216 10.1111/j.1600-065X.1997.tb00983.x 9255631 (Pubitemid 27303130)
5. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. RH Collins Jr O Shpilberg WR Drobyski DL Porter S Giralt R Champlin SA Goodman SN Wolff W Hu C Verfaillie A List W Dalton N Ognoskie A Chetrit JH Antin J Nemunaitis, J Clin Oncol 1997 15 433 444 9053463
6. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. ME Dudley JR Wunderlich PF Robbins JC Yang P Hwu DJ Schwartzentruber SL Topalian R Sherry NP Restifo AM Hubicki MR Robinson M Raffeld P Duray CA Seipp L Rogers-Freezer KE Morton SA Mavroukakis DE White SA Rosenberg, Science 2002 298 850 854 10.1126/science.1076514 12242449 (Pubitemid 35231542)
7. Adoptive immunotherapy for cancer: building on success. L Gattinoni DJ Powell Jr SA Rosenberg NP Restifo, Nat Rev Immunol 2006 6 383 393 10.1038/nri1842 16622476
8. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. SA Rosenberg NP Restifo JC Yang RA Morgan ME Dudley, Nat Rev Cancer 2008 8 299 308 10.1038/nrc2355 18354418
9. CD8+ T-cell memory in tumor immunology and immunotherapy. CA Klebanoff L Gattinoni NP Restifo, Immunol Rev 2006 211 214 224 10.1111/j.0105-2896.2006. 00391.x 16824130 (Pubitemid 43882974)
10. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. C Yee PA Savage PP Lee MM Davis PD Greenberg, J Immunol 1999 162 2227 2234 9973498
11. Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers. S Szmania A Galloway M Bruorton P Musk G Aubert A Arthur H Pyle N Hensel N Ta L Lamb Jr T Dodi A Madrigal J Barrett J Henslee-Downey F van Rhee, Blood 2001 98 505 512 10.1182/blood.V98.3.505 11468143
12. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. G Rauser H Einsele C Sinzger D Wernet G Kuntz M Assenmacher JD Campbell MS Topp, Blood 2004 103 3565 3572 10.1182/blood-2003-09-3056 14670917 (Pubitemid 38525695)
13. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. T Feuchtinger S Matthes-Martin C Richard T Lion M Fuhrer K Hamprecht R Handgretinger C Peters FR Schuster R Beck M Schumm R Lotn G Jahn P Lang, Br J Haematol 2006 134 64 76 10.1111/j.1365-2141.2006.06108.x 16803570 (Pubitemid 43830030)
14. Adoptive cellular therapy for cytomegalovirus infection following allogeneic stem cell transplantation using virus-specific T cells. S Mackinnon K Thomson S Verfuerth K Peggs M Lowdell, Blood Cells Mol Dis 2008 40 63 67 10.1016/j.bcmd.2007.07.003 17869548 (Pubitemid 350192302)
15. Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. M Wolfl J Kuball WY Ho H Nguyen TJ Manley M Bleakley PD Greenberg, Blood 2007 110 201 210 10.1182/blood-2006-11- 056168 17371945 (Pubitemid 47026836)
16. Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells. S Han B Wang MJ Cotter LJ Yang J Zucali JS Moreb L-J Chang, Mol Ther 2008 16 269 279 10.1038/sj.mt.6300369 18071334 (Pubitemid 351168035)
17. A rapid method for starting a culture for the establishment of Epstein-Barr virus-transformed human lymphoblastoid cell lines. Y Fukushima H Ohashi K Wakui T Nishida T Oh-ishi, Jpn J Hum Genet 1992 37 149 150 10.1007/BF01899737 1327290
18. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. MR Betts JM Brenchley DA Price SC De Rosa DC Douek M Roederer RA Koup, J Immunol Methods 2003 281 65 78 10.1016/S0022-1759(03)00265-5 14580882 (Pubitemid 37324571)
19. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. AB Lyons, J Immunol Methods 2000 243 147 154 10.1016/S0022-1759(00)00231-3 10986412 (Pubitemid 30734599)
20. New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population. I Jedema NM van der Werff RM Barge R Willemze JH Falkenburg, Blood 2004 103 2677 2682 10.1182/blood-2003-06-2070 14630824 (Pubitemid 38393024)
21. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus - specific T lymphocytes. KC Straathof CM Bollard U Popat MH Huls T Lopez MC Morriss MV Gresik AP Gee HV Russell MK Brenner CM Rooney HE Heslop, Blood 2005 105 1898 1904 10.1182/blood-2004-07-2975 15542583 (Pubitemid 40731770)
22. Rapid identification and sorting of viable virus-reactive CD4(+) and CD8(+) T cells based on antigen-triggered CD137 expression. TC Wehler M Karg E Distler A Konur M Nonn RG Meyer C Huber UF Hartwig W Herr, J Immunol Methods 2008 339 23 37 10.1016/j.jim.2008.07.017 18760281
23. Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors. M Dauer B Obermaier J Herten C Haerle K Pohl S Rothenfusser M Schnurr S Endres A Eigler, J Immunol 2003 170 4069 4076 12682236
24. T cell homeostatic proliferation elicits effective antitumor autoimmunity. W Dummer AG Niethammer R Baccala BR Lawson N Wagner RA Reisfeld AN Theofilopoulos, J Clin Invest 2002 110 185 192 12122110
25. Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. CA Klebanoff HT Khong PA Antony DC Palmer NP Restifo, Trends Immunol 2005 26 111 117 10.1016/j.it.2004.12.003 15668127
26. Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells. C Wrzesinski CM Paulos L Gattinoni DC Palmer A Kaiser Z Yu SA Rosenberg NP Restifo, J Clin Invest 2007 117 492 501 10.1172/JCI30414 17273561 (Pubitemid 46203978)
27. CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy. K Watanabe S Suzuki M Kamei S Toji T Kawase T Takahashi K Kuzushima Y Akatsuka, Int J Hematol 2008 88 311 320 10.1007/s12185-008-0134-z 18677654
28. Molecular and biological characterization of human 4-1BB and its ligand. MR Alderson CA Smith TW Tough T Davis-Smith RJ Armitage B Falk E Roux E Baker GR Sutherland WS Din, Eur J Immunol 1994 24 2219 2227 10.1002/eji.1830240943 8088337
29. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. T Wen J Bukczynski TH Watts, J Immunol 2002 168 4897 4906 11994439
30. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Y Zhu G Zhu L Luo AS Flies L Chen, Blood 2007 109 4882 4889 10.1182/blood-2006-10-043463 17244673 (Pubitemid 46827785)
31. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. JC Sun MA Williams MJ Bevan, Nat Immunol 2004 5 927 933 10.1038/ni1105 15300249 (Pubitemid 39276237)
32. Central memory and effector memory T cell subsets: function, generation, and maintenance. F Sallusto J Geginat A Lanzavecchia, Annu Rev Immunol 2004 22 745 763 10.1146/annurev.immunol.22.012703.104702 15032595 (Pubitemid 38680440)
33. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. M Nascimbeni EC Shin L Chiriboga DE Kleiner B Rehermann, Blood 2004 104 478 486 10.1182/blood-2003-12-4395 15044252 (Pubitemid 38900031)
34. Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. L Gattinoni CA Klebanoff DC Palmer C Wrzesinski K Kerstann Z Yu SE Finkelstein MR Theoret SA Rosenberg NP Restifo, J Clin Invest 2005 115 1616 1626 10.1172/JCI24480 15931392 (Pubitemid 40814670)
35. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. CA Klebanoff L Gattinoni P Torabi-Parizi K Kerstann AR Cardones SE Finkelstein DC Palmer PA Antony ST Hwang SA Rosenberg TA Waldmann NP Restifo, Proc Natl Acad Sci USA 2005 102 9571 9576 10.1073/pnas.0503726102 15980149 (Pubitemid 40981722)
36. Improving T cell therapy for cancer. AM Leen CM Rooney AE Foster, Annu Rev Immunol 2007 25 243 265 10.1146/annurev.immunol.25.022106.141527 17129181 (Pubitemid 46697909)
37. Preferential localization of effector memory cells in nonlymphoid tissue. D Masopust V Vezys AL Marzo L Lefrancois, Science 2001 291 2413 2417 10.1126/science.1058867 11264538 (Pubitemid 32231804)
38. Bone marrow contains melanoma-reactive CD8+ effector T cells and, compared with peripheral blood, enriched numbers of melanoma-reactive CD8+ memory T cells. A Letsch U Keilholz G Assfalg V Mailander E Thiel C Scheibenbogen, Cancer Res 2003 63 5582 5586 14500398
39. Bone marrow contains virus-specific cytotoxic T lymphocytes. MK Slifka JK Whitmire R Ahmed, Blood 1997 90 2103 2108 9292550
40. CD8+ memory T lymphocytes from bone marrow - immune function and therapeutic potential. AH Wood X Zhang DL Farber SE Strome, Crit Rev Immunol 2007 27 527 537 18197798
41. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. MV Soares NJ Borthwick MK Maini G Janossy M Salmon AN Akbar, J Immunol 1998 161 5909 5917 9834071
42. Development of CTL memory despite arrested clonal expansion. MJ van Stipdonk M Sluijter WG Han R Offringa, Eur J Immunol 2008 38 1839 1846 10.1002/eji.200737974 18581321
43. Treatment of Epstein-Barr-virus-positive post-transplantation lymphoproliferative disease with partly HLA-matched allogeneic cytotoxic T cells. T Haque GM Wilkie C Taylor PL Amlot P Murad A Iley D Dombagoda KM Britton AJ Swerdlow DH Crawford, Lancet 2002 360 436 442 10.1016/S0140-6736(02)09672-1 12241714 (Pubitemid 34880139)
44. Adoptive immunotherapy with allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes for recurrent, EBV-positive Hodgkin disease. KG Lucas D Salzman A Garcia Q Sun, Cancer 2004 100 1892 1901 10.1002/cncr.20188 15112270 (Pubitemid 38529567)
45. Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers. M Cobbold N Khan B Pourgheysari S Tauro D McDonald H Osman M Assenmacher L Billingham C Steward C Crawley E Olavarria J Goldman R Chakraverty P Mahendra C Craddock PA Moss, J Exp Med 2005 202 379 386 10.1084/jem.20040613 16061727 (Pubitemid 41126955)
46. Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation. PJ Amrolia G Muccioli-Casadei H Huls S Adams A Durett A Gee E Yvon H Weiss M Cobbold HB Gaspar C Rooney L Kuehnle V Ghetie J Schindler R Krance HE Heslop P Veys E Vitetta MK Brenner, Blood 2006 108 1797 1808 10.1182/blood-2006-02-001909 16741253 (Pubitemid 44394986)
47. Breaking tolerance in cancer immunotherapy: time to ACT. WW Overwijk, Curr Opin Immunol 2005 17 187 194 10.1016/j.coi.2005.01.011 15766680 (Pubitemid 40343107)
48. Immunosuppressive strategies that are mediated by tumor cells. GA Rabinovich D Gabrilovich EM Sotomayor, Annu Rev Immunol 2007 25 267 296 10.1146/annurev.immunol.25.022106.141609 17134371 (Pubitemid 46697910)