Soluble corticotropin-releasing hormone receptor 2α splice variant is efficiently translated but not trafficked for secretion

Endocrinology

Volumn 150, Issue 9, 2009, Pages 4191-4202

  Evans, Ryan T ^a   Seasholtz, Audrey F ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2ALPHA; CYCLOHEXIMIDE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PROTEASOME; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN REGION; CODON; CONTROLLED STUDY; DIMERIZATION; GENOME; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LIGAND BINDING; MALE; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ALTERNATIVE SPLICING; ANIMALS; BRAIN; CELL LINE; CODON, NONSENSE; HUMANS; MALE; MICE; MICE, INBRED C57BL; POLYRIBOSOMES; PROTEIN TRANSPORT; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RNA, MESSENGER; SECRETORY PATHWAY;

EID: 69249142330     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0285     Document Type: Article

References (69)

1. Owens MJ, Nemeroff CB 1991 Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 43:425-473
2. Dunn AJ, Berridge CW 1990 Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev 15:71-100
3. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W 1995 Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378:287-292
4. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW 2001 Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci USA 98:7570-7575
5. Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW, Sawchenko PE 2001 Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci USA 98:2843-2848
6. Hsu SY, Hsueh AJ 2001 Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med 7:605-611
7. Fekete EM, Zorrilla EP 2007 Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Front Neuroendocrinol 28:1-27
8. Oki Y, Sasano H 2004 Localization and physiological roles of urocortin. Peptides 25:1745-1749
9. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB 1999 The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160:1-12
10. Bailer UF, Kaye WH 2003 A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosa. Curr Drug Targets CNS Neurol Disord 2:53-59
11. Jessop DS, Harbuz MS, Lightman SL 2001 CRH in chronic inflammatory stress. Peptides 22:803-807
12. Gravanis A, Margioris AN 2005 The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Curr Med Chem 12:1503-1512
13. Charles CJ, Rademaker MT, Richards AM 2004 Urocortins: putative role in cardiovascular disease. Curr Med Chem Cardiovasc Hematol Agents 2:43-47
14. Hillhouse EW, Grammatopoulos DK 2006 The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev 27:260-286
15. Van Pett K, Viau V, Bittencourt JC, Chan RK, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE 2000 Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428:191-212
16. Bale TL, Vale WW 2004 CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44:525-557
17. Pisarchik A, Slominski A 2004 Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem 271:2821-2830
18. Pisarchik A, Slominski AT 2001 Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J 15:2754-2756
19. Grammatopoulos DK 2008 Placental corticotrophin-releasing hormone and its receptors in human pregnancy and labour: still a scientific enigma. J Neuroendocrinol 20:432-438
20. Zmijewski MA, Slominski AT 2009 CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations. J Cell Physiol 218:593-602
21. Markovic D, Lehnert H, Levine MA, Grammatopoulos DK 2008 Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d. Mol Endocrinol 22:2505-2519
22. Kostich WA, Chen A, Sperle K, Largent BL 1998 Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2γ receptor. Mol Endocrinol 12:1077-1085
23. Chen A, Perrin M, Brar B, Li C, Jamieson P, Digruccio M, Lewis K, Vale W 2005 Mouse corticotropin-releasing factor receptor type 2α gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol 19:441-458
24. Lovenberg TW, Chalmers DT, Liu C, De Souza EB 1995 CRF2α and CRF2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 136:4139-4142
25. 2(a) receptor splice variant. Regul Pept 121:89-97
26. Perrin M, Donaldson C, Chen R, Blount A, Berggren T, Bilezikjian L, Sawchenko P, Vale W 1995 Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci USA 92:2969-2973
27. Stenzel P, Kesterson R, Yeung W, Cone RD, Rittenberg MB, Stenzel-Poore MP 1995 Identification of a novel murine receptor for corticotropin- releasing hormone expressed in the heart. Mol Endocrinol 9:637-645
28. Potter E, Behan DP, Fischer WH, Linton EA, Lowry PJ, Vale WW 1991 Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 349:423-426
29. Westphal NJ, Seasholtz AF 2006 CRH-BP: the regulation and function of a phylogenetically conserved binding protein. Front Biosci 11:1878-1891
30. 2 receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) 193:283-294
31. Chen AM, Perrin MH, Digruccio MR, Vaughan JM, Brar BK, Arias CM, Lewis KA, Rivier JE, Sawchenko PE, Vale WW 2005 A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity. Proc Natl Acad Sci USA 102:2620-2625
32. Chang YF, Imam JS, Wilkinson MF 2007 The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76:51-74
33. McGlincy NJ, Smith CW 2008 Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? Trends Biochem Sci 33:385-393
34. Denecke J, Kranz C, Kemming D, Koch HG, Marquardt T 2004 An activated 5′ cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id). Hum Mutat 23:477-486
35. Dreumont N, Maresca A, Boisclair-Lachance JF, Bergeron A, Tanguay RM 2005 A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay. BMC Mol Biol 6:1-12
36. Ruiz-Echevarría MJ, Peltz SW 2000 The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell 101:741-751
37. Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH 2006 The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). Nucleic Acids Res 34:2355-2363
38. Rutz C, Renner A, Alken M, Schulz K, Beyermann M, Wiesner B, Rosenthal W, Schülein R 2006 The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J Biol Chem 281:24910-24921
39. Apaja PM, Tuusa JT, Pietilä EM, Rajaniemi HJ, Petäjä-Repo UE 2006 Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum. Mol Biol Cell 17:2243-2255
40. Biocca S, Filesi I, Mango R, Maggiore L, Baldini F, Vecchione L, Viola A, Citro G, Federici G, Romeo F, Novelli G 2008 The splice variant LOXIN inhibits LOX-1 receptor function through heterooligomerization. J Mol Cell Cardiol 44:561-570
41. Seck T, Baron R, Horne WC 2003 The alternatively spliced Δe13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expression. J Biol Chem 278:23085-23093
42. Brothers SP, Cornea A, Janovick JA, Conn PM 2004 Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Mol Endocrinol 18:1787-1797
43. Karpa KD, Lin R, Kabbani N, Levenson R 2000 The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Mol Pharmacol 58:677-683
44. Minegishi T, Nakamura K, Yamashita S, Omori Y 2007 The effect of splice variant of the human luteinizing hormone (LH) receptor on the expression of gonadotropin receptor. Mol Cell Endocrinol 260-262:117-125
45. Sarmiento JM, Añazco CC, Campos DM, Prado GN, Navarro J, González CB 2004 Novel down-regulatory mechanism of the surface expression of the vasopressin V2 receptor by an alternative splice receptor variant. J Biol Chem 279:47017-47023
46. Westphal NJ, Seasholtz AF 2005 Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in αT3-1 cells. Mol Endocrinol 19:2780-2797
47. Westphal NJ, Evans RT, Seasholtz AF 2009 Novel expression of type 1 CRH receptor in multiple endocrine cell types in the murine anterior pituitary. Endocrinology 150:260-267
48. Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
49. Garrett JE, Collard MW, Douglass JO 1989 Translational control of germ cell-expressed mRNA imposed by alternative splicing: opioid peptide gene expression in rat testis. Mol Cell Biol 9:4381-4389
50. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
51. Seasholtz AF, Thompson RC, Douglass JO 1988 Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene. Mol Endocrinol 2:1311-1319
52. Maya-Núñez G, Castro-Fernández C, Méndez JP 2005 CRH-stimulation of cyclic adenosine 5′-monophosphate pathway is partially inhibited by the coexpression of CRH-R1 and CRH-R2α. Endocrine 27:67-73
53. Assil-Kishawi I, Abou-Samra AB 2002 Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor. J Biol Chem 277:32558-32561
54. Seasholtz AF, Ohman M, Wardani A, Thompson RC 2009 Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells. J Endocrinol 200:223-232
55. Soller M 2006 Pre-messenger RNA processing and its regulation: a genomic perspective. Cell Mol Life Sci 63:796-819
56. Stamm S, Ben-Ari S, Rafalska I, Tang Y, Zhang Z, Toiber D, Thanaraj TA, Soreq H 2005 Function of alternative splicing. Gene 344:1-20
57. Lejeune F, Maquat LE 2005 Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol 17:309-315
58. Cuccurese M, Russo G, Russo A, Pietropaolo C 2005 Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res 33:5965-5977
59. Hawkins J, Davis L, Bodén M 2007 Predicting nuclear localization. J Proteome Res 6:1402-1409
60. Kraetke O, Wiesner B, Eichhorst J, Furkert J, Bienert M, Beyermann M 2005 Dimerization of corticotropin-releasing factor receptor type1is not coupled to ligand binding. J Recept Signal Transduct Res 25:251-276
61. Mikhailova MV, Mayeux PR, Jurkevich A, Kuenzel WJ, Madison F, Periasamy A, Chen Y, Cornett LE 2007 Heterooligomerization between vasotocin and corticotropin-releasing hormone (CRH) receptors augments CRH-stimulated 3′,5′-cyclic adenosine monophosphate production. Mol Endocrinol 21:2178-2188
62. Young SF, Griffante C, Aguilera G 2007 Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. Cell Mol Neurobiol 27:439-461
63. Wu SV, Yuan PQ, Wang L, Peng YL, Chen CY, Taché Y 2007 Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagus. Endocrinology 148:1675-1687
64. Klenerova V, Sery O, Hynie S 2008 Corticotropin-releasing hormone receptor subtypes in the rat anterior pituitary after two types of restraint stress. Ann NY Acad Sci 1148:415-420
65. Kroeger KM, Pfleger KD, Eidne KA 2003 G-protein coupled receptor oligomerization in neuroendocrine pathways. Front Neuroendocrinol 24:254-278
66. Sztainberg Y, Kuperman Y, Issler O, Gil S, Vaughan J, Rivier J, Vale W, Chen A 26 February 2009 A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease. FASEB J 10.1096/fj.08-128066
67. Grammatopoulos DK 2007 The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour. Front Biosci 12:561-571
68. Markovic D, Vatish M, Gu M, Slater D, Newton R, Lehnert H, Grammatopoulos DK 2007 The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1β. Endocrinology 148:3205-3213
69. Kageyama K, Li C, Vale WW 2003 Corticotropin-releasing factor receptor type 2 messenger ribonucleic acid in rat pituitary: localization and regulation by immune challenge, restraint stress, and glucocorticoids. Endocrinology 144:1524-1532