Design, synthesis, and biological evaluation of the N-diarylalkenyl- piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I)

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 225-227

  Zheng, Jianbin ^a   Wen, Ren ^a   Luo, Xiaomin ^b   Lin, Guoqiang ^c   Zhang, Jiange ^a   Xu, Linfeng ^d   Guo, Lihe ^d   Jiang, Hualiang ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Antiepileptic; GABA uptake inhibitors; GAT1; N Diarylalkenyl piperidinecarboxylic acid derivatives

Indexed keywords

1 [4,4 BIS(3 PHENOXYMETHYL 2 THIENYL) 3 BUTENYL] 3 PIPERIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; TIAGABINE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL TRANSPORT; CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NEURONS; NIPECOTIC ACIDS; PIPECOLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744564797     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.004     Document Type: Article

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