메뉴 건너뛰기




Volumn 15, Issue 20, 2009, Pages 2311-2318

The therapeutic potential of ADAM15

Author keywords

ADAM15; ADAMs; Cancer; Inflammation; Metargidin; Proteinase

Indexed keywords

ADAM PROTEIN; ADAM15 INHIBITOR; ADAM15 PROTEIN; AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INCB 3619; INCB 7839; METALLOPROTEINASE INHIBITOR; PROTEINASE INHIBITOR; RECOMBINANT HUMAN ADAM15 DISINTEGRIN DOMAIN; RECOMBINANT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN;

EID: 69249117409     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161209788682370     Document Type: Review
Times cited : (19)

References (81)
  • 2
    • 0033731921 scopus 로고    scopus 로고
    • Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage
    • Gutierrez JM, Rucavado A. Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage. Biochimie 2000; 82: 841-50
    • (2000) Biochimie , vol.82 , pp. 841-850
    • Gutierrez, J.M.1    Rucavado, A.2
  • 4
    • 0034714890 scopus 로고    scopus 로고
    • The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
    • McCulloch DR, Harvey M, Herington AC. The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. Mol Cell Endocrinol 2000; 167: 11-21.
    • (2000) Mol Cell Endocrinol , vol.167 , pp. 11-21
    • McCulloch, D.R.1    Harvey, M.2    Herington, A.C.3
  • 5
    • 0034141195 scopus 로고    scopus 로고
    • The ADAM gene family: Surface proteins with adhesion and protease activity
    • Primakoff P, Myles DG. The ADAM gene family: Surface proteins with adhesion and protease activity. Trends Genet 2000; 16: 83-7.
    • (2000) Trends Genet , vol.16 , pp. 83-87
    • Primakoff, P.1    Myles, D.G.2
  • 6
    • 0029670028 scopus 로고    scopus 로고
    • Kratzschmar J, Lum L, Blobel CP. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. J Biol Chem 1996; 271: 4593-6.
    • Kratzschmar J, Lum L, Blobel CP. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. J Biol Chem 1996; 271: 4593-6.
  • 7
    • 0031025031 scopus 로고    scopus 로고
    • Expression of a disintegrin-like protein in cultured human vascular cells and in vivo
    • Herren B, Raines EW, Ross R. Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. FASEB J 1997; 11: 173-80.
    • (1997) FASEB J , vol.11 , pp. 173-180
    • Herren, B.1    Raines, E.W.2    Ross, R.3
  • 8
    • 56749133149 scopus 로고    scopus 로고
    • The ADAMs: Signalling scissors in the tumour micro-environment
    • Murphy G. The ADAMs: Signalling scissors in the tumour micro-environment. Nat Rev Cancer 2009; 8: 929-41.
    • (2009) Nat Rev Cancer , vol.8 , pp. 929-941
    • Murphy, G.1
  • 10
    • 0035880481 scopus 로고    scopus 로고
    • Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization
    • Balazs M, Adam Z, Treszl A, Begany A, Hunyadi J, Adany R. Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization. Cytometry 2001; 46: 222-32.
    • (2001) Cytometry , vol.46 , pp. 222-232
    • Balazs, M.1    Adam, Z.2    Treszl, A.3    Begany, A.4    Hunyadi, J.5    Adany, R.6
  • 11
    • 0035130569 scopus 로고    scopus 로고
    • Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization
    • El Gedaily A, Bubendorf L, Willi N, Fu W, Richter J, Moch H, et al. Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization. Prostate 2001; 46: 184-90.
    • (2001) Prostate , vol.46 , pp. 184-190
    • El Gedaily, A.1    Bubendorf, L.2    Willi, N.3    Fu, W.4    Richter, J.5    Moch, H.6
  • 12
    • 0037564023 scopus 로고    scopus 로고
    • Malignancy-associated regions of transcriptional activation: Gene expression profiling identifies common chromosomal regions of a recurrent transcriptional activation in human prostate, breast, ovarian, and colon cancers
    • Glinsky GV, Krones-Herzig A, Glinskii AB. Malignancy-associated regions of transcriptional activation: Gene expression profiling identifies common chromosomal regions of a recurrent transcriptional activation in human prostate, breast, ovarian, and colon cancers. Neoplasia 2003; 5: 218-28.
    • Neoplasia 2003
    • Glinsky, G.V.1    Krones-Herzig, A.2    Glinskii, A.B.3
  • 13
    • 0342369476 scopus 로고    scopus 로고
    • Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization
    • Karkkainen I, Karhu R, Huovila AP. Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization. Cytogenet Cell Genet 2000; 88: 206-7.
    • (2000) Cytogenet Cell Genet , vol.88 , pp. 206-207
    • Karkkainen, I.1    Karhu, R.2    Huovila, A.P.3
  • 14
    • 33646408392 scopus 로고    scopus 로고
    • ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease
    • Kuefer R, Day KC, Kleer CG, Sabel MS, Hofer MD, Varambally S, et al. ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease. Neoplasia 2006; 8: 319-29.
    • (2006) Neoplasia , vol.8 , pp. 319-329
    • Kuefer, R.1    Day, K.C.2    Kleer, C.G.3    Sabel, M.S.4    Hofer, M.D.5    Varambally, S.6
  • 15
    • 39449130768 scopus 로고    scopus 로고
    • ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction
    • Najy AJ, Day KC, Day ML. ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res 2008; 68: 1092-9.
    • (2008) Cancer Res , vol.68 , pp. 1092-1099
    • Najy, A.J.1    Day, K.C.2    Day, M.L.3
  • 17
    • 52049111595 scopus 로고    scopus 로고
    • Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor
    • Witters L, Scherle P, Friedman S, Fridman J, Caulder E, Newton R, et al. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res 2008; 68: 7083-9.
    • (2008) Cancer Res , vol.68 , pp. 7083-7089
    • Witters, L.1    Scherle, P.2    Friedman, S.3    Fridman, J.4    Caulder, E.5    Newton, R.6
  • 19
    • 19644374948 scopus 로고    scopus 로고
    • The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
    • Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Rocken C. The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol 2005; 26: 17-24.
    • (2005) Int J Oncol , vol.26 , pp. 17-24
    • Carl-McGrath, S.1    Lendeckel, U.2    Ebert, M.3    Roessner, A.4    Rocken, C.5
  • 23
    • 0036405405 scopus 로고    scopus 로고
    • ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin
    • Ham C, Levkau B, Raines EW, Herren B. ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin. Exp Cell Res 2002; 279: 239-47.
    • (2002) Exp Cell Res , vol.279 , pp. 239-247
    • Ham, C.1    Levkau, B.2    Raines, E.W.3    Herren, B.4
  • 24
    • 0032091809 scopus 로고    scopus 로고
    • IReview: Angiogenesis: implications for rheumatoid arthritis
    • Koch AE.IReview: Angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum 1998; 41: 951-62.
    • (1998) Arthritis Rheum , vol.41 , pp. 951-962
    • Koch, A.E.1
  • 25
    • 33644666813 scopus 로고    scopus 로고
    • Expression of ADAM15 in rheumatoid synovium: Up-regulation by vascular endothelial growth factor and possible implications for angiogenesis
    • Komiya K, Enomoto H, Inoki I, Okazaki S, Fujita Y, Ikeda E, et al. Expression of ADAM15 in rheumatoid synovium: Up-regulation by vascular endothelial growth factor and possible implications for angiogenesis. Arthritis Res Ther 2005; 7: R1158-73.
    • (2005) Arthritis Res Ther , vol.7
    • Komiya, K.1    Enomoto, H.2    Inoki, I.3    Okazaki, S.4    Fujita, Y.5    Ikeda, E.6
  • 27
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    • Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2: 737-44.
    • (2000) Nat Cell Biol , vol.2 , pp. 737-744
    • Bergers, G.1    Brekken, R.2    McMahon, G.3    Vu, T.H.4    Itoh, T.5    Tamaki, K.6
  • 28
    • 0033943076 scopus 로고    scopus 로고
    • Role of alpha v integrins during angiogenesis
    • Eliceiri BP, Cheresh DA. Role of alpha v integrins during angiogenesis. Cancer J 2000; 6(Suppl 3): S245-9.
    • (2000) Cancer J , vol.6 , Issue.SUPPL. 3
    • Eliceiri, B.P.1    Cheresh, D.A.2
  • 29
    • 0034721888 scopus 로고    scopus 로고
    • Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A
    • Kim S, Harris M, Varner JA. Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem 2000; 275: 33920-8.
    • (2000) J Biol Chem , vol.275 , pp. 33920-33928
    • Kim, S.1    Harris, M.2    Varner, J.A.3
  • 30
    • 0035216201 scopus 로고    scopus 로고
    • Adhesion receptors of vascular smooth muscle cells and their functions
    • Moiseeva EP. Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovasc Res 2001; 52: 372-86.
    • (2001) Cardiovasc Res , vol.52 , pp. 372-386
    • Moiseeva, E.P.1
  • 31
    • 40449132187 scopus 로고    scopus 로고
    • ADAM-15: A metalloprotease that mediates inflammation
    • Charrier-Hisamuddin L, Laboisse CL, Merlin D. ADAM-15: A metalloprotease that mediates inflammation. FASEB J 2008; 22: 641-53.
    • (2008) FASEB J , vol.22 , pp. 641-653
    • Charrier-Hisamuddin, L.1    Laboisse, C.L.2    Merlin, D.3
  • 33
    • 0038650592 scopus 로고    scopus 로고
    • Increased expression of disintegrin-metalloproteinases ADAM-15 and ADAM-9 following upregulation of integrins alpha5beta1 and alphavbeta3 in atherosclerosis
    • Al-Fakhri N, Wilhelm J, Hahn M, Heidt M, Hehrlein FW, Endisch AM, et al. Increased expression of disintegrin-metalloproteinases ADAM-15 and ADAM-9 following upregulation of integrins alpha5beta1 and alphavbeta3 in atherosclerosis. J Cell Biochem 2003; 89: 808-23.
    • (2003) J Cell Biochem , vol.89 , pp. 808-823
    • Al-Fakhri, N.1    Wilhelm, J.2    Hahn, M.3    Heidt, M.4    Hehrlein, F.W.5    Endisch, A.M.6
  • 34
    • 0032969233 scopus 로고    scopus 로고
    • Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells
    • Nath D, Slocombe PM, Stephens PE, Warn A, Hutchinson GR, Yamada KM, et al. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. J Cell Sci 1999; 112 (Pt 4): 579-87.
    • (1999) J Cell Sci , vol.112 , Issue.PART 4 , pp. 579-587
    • Nath, D.1    Slocombe, P.M.2    Stephens, P.E.3    Warn, A.4    Hutchinson, G.R.5    Yamada, K.M.6
  • 35
    • 0032571315 scopus 로고    scopus 로고
    • Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3
    • Zhang XP, Kamata T, Yokoyama K, Puzon-McLaughlin W, Takada Y. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. J Biol Chem 1998; 273: 7345-50.
    • (1998) J Biol Chem , vol.273 , pp. 7345-7350
    • Zhang, X.P.1    Kamata, T.2    Yokoyama, K.3    Puzon-McLaughlin, W.4    Takada, Y.5
  • 36
    • 24944550148 scopus 로고    scopus 로고
    • ADAM 15 is an adhesion receptor for platelet GPIIb-IIIa and induces platelet activation
    • Langer H, May AE, Bultmann A, Gawaz M. ADAM 15 is an adhesion receptor for platelet GPIIb-IIIa and induces platelet activation. Thromb Haemost 2005; 94: 555-61.
    • (2005) Thromb Haemost , vol.94 , pp. 555-561
    • Langer, H.1    May, A.E.2    Bultmann, A.3    Gawaz, M.4
  • 37
    • 38149052992 scopus 로고    scopus 로고
    • Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    • Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008; 58: 26-35.
    • (2008) Arthritis Rheum , vol.58 , pp. 26-35
    • Lawrence, R.C.1    Felson, D.T.2    Helmick, C.G.3    Arnold, L.M.4    Choi, H.5    Deyo, R.A.6
  • 38
    • 0035462010 scopus 로고    scopus 로고
    • Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue
    • Bohm BB, Aigner T, Blobel CP, Kalden JR, Burkhardt H. Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue. Arthritis Rheum 2001; 44: 2046-54.
    • (2001) Arthritis Rheum , vol.44 , pp. 2046-2054
    • Bohm, B.B.1    Aigner, T.2    Blobel, C.P.3    Kalden, J.R.4    Burkhardt, H.5
  • 40
    • 17244371476 scopus 로고    scopus 로고
    • Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling
    • Bohm BB, Aigner T, Roy B, Brodie TA, Blobel CP, Burkhardt H. Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum 2005; 52: 1100-9.
    • (2005) Arthritis Rheum , vol.52 , pp. 1100-1109
    • Bohm, B.B.1    Aigner, T.2    Roy, B.3    Brodie, T.A.4    Blobel, C.P.5    Burkhardt, H.6
  • 41
    • 72949108039 scopus 로고    scopus 로고
    • Adam15 Modulates Outside-in Signaling in Chondrocyte-Matrix Interactions
    • In press
    • Bohm BB, Schirner A, Burkhardt H. Adam15 Modulates Outside-in Signaling in Chondrocyte-Matrix Interactions. J Cell Mol Med 2008; In press.
    • (2008) J Cell Mol Med
    • Bohm, B.B.1    Schirner, A.2    Burkhardt, H.3
  • 42
    • 33745714456 scopus 로고    scopus 로고
    • ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
    • Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 2006; 291: C1-10.
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Ohtsu, H.1    Dempsey, P.J.2    Eguchi, S.3
  • 43
    • 9144252129 scopus 로고    scopus 로고
    • Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
    • Schafer B, Marg B, Gschwind A, Ullrich A. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J Biol Chem 2004; 279: 47929-38.
    • (2004) J Biol Chem , vol.279 , pp. 47929-47938
    • Schafer, B.1    Marg, B.2    Gschwind, A.3    Ullrich, A.4
  • 44
    • 26844556553 scopus 로고    scopus 로고
    • GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways
    • Hart S, Fischer OM, Prenzel N, Zwick-Wallasch E, Schneider M, Hennighausen L, et al. GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways. Biol Chem 2005; 386: 845-55.
    • (2005) Biol Chem , vol.386 , pp. 845-855
    • Hart, S.1    Fischer, O.M.2    Prenzel, N.3    Zwick-Wallasch, E.4    Schneider, M.5    Hennighausen, L.6
  • 45
    • 42249085067 scopus 로고    scopus 로고
    • Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling
    • Boscher C, Mege RM. Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling. Cell Signal 2008; 20: 1061-72.
    • (2008) Cell Signal , vol.20 , pp. 1061-1072
    • Boscher, C.1    Mege, R.M.2
  • 46
    • 0028360311 scopus 로고
    • Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins
    • Schafer S, Koch PJ, Franke WW. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res 1994; 211: 391-9.
    • (1994) Exp Cell Res , vol.211 , pp. 391-399
    • Schafer, S.1    Koch, P.J.2    Franke, W.W.3
  • 47
    • 0036781973 scopus 로고    scopus 로고
    • A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    • Suyama K, Shapiro I, Guttman M, Hazan RB. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2002; 2: 301-14.
    • (2002) Cancer Cell , vol.2 , pp. 301-314
    • Suyama, K.1    Shapiro, I.2    Guttman, M.3    Hazan, R.B.4
  • 48
    • 49649103585 scopus 로고    scopus 로고
    • The ectodomain shedding of Ecadherin by ADAM15 supports ErbB receptor activation
    • Najy AJ, Day KC, Day ML. The ectodomain shedding of Ecadherin by ADAM15 supports ErbB receptor activation. J Biol Chem 2008; 283: 18393-401.
    • (2008) J Biol Chem , vol.283 , pp. 18393-18401
    • Najy, A.J.1    Day, K.C.2    Day, M.L.3
  • 50
    • 0033615602 scopus 로고    scopus 로고
    • Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1
    • Howard L, Nelson KK, Maciewicz RA, Blobel CP. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J Biol Chem 1999; 274: 31693-9.
    • (1999) J Biol Chem , vol.274 , pp. 31693-31699
    • Howard, L.1    Nelson, K.K.2    Maciewicz, R.A.3    Blobel, C.P.4
  • 51
    • 0037930878 scopus 로고    scopus 로고
    • The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells
    • Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, et al. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem 2003; 278: 16844-51.
    • (2003) J Biol Chem , vol.278 , pp. 16844-16851
    • Abram, C.L.1    Seals, D.F.2    Pass, I.3    Salinsky, D.4    Maurer, L.5    Roth, T.M.6
  • 52
    • 4744355650 scopus 로고    scopus 로고
    • ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands
    • Tanaka M, Nanba D, Mori S, Shiba F, Ishiguro H, Yoshino K, et al. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. J Biol Chem 2004; 279: 41950-9.
    • (2004) J Biol Chem , vol.279 , pp. 41950-41959
    • Tanaka, M.1    Nanba, D.2    Mori, S.3    Shiba, F.4    Ishiguro, H.5    Yoshino, K.6
  • 53
    • 0037085256 scopus 로고    scopus 로고
    • Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    • Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem 2002; 277: 4999-5007.
    • (2002) J Biol Chem , vol.277 , pp. 4999-5007
    • Poghosyan, Z.1    Robbins, S.M.2    Houslay, M.D.3    Webster, A.4    Murphy, G.5    Edwards, D.R.6
  • 54
    • 0034424220 scopus 로고    scopus 로고
    • Src inhibitors: Drugs for the treatment of osteoporosis, cancer or both?
    • Susva M, Missbach M, Green J. Src inhibitors: Drugs for the treatment of osteoporosis, cancer or both? Trends Pharmacol Sci 2000; 21: 489-95
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 489-495
    • Susva, M.1    Missbach, M.2    Green, J.3
  • 55
    • 0037150728 scopus 로고    scopus 로고
    • Frame MC. Src in cancer: Deregulation and consequences for cell behaviour. Biochim Biophys Acta 2002; 1602: 114-30.
    • Frame MC. Src in cancer: Deregulation and consequences for cell behaviour. Biochim Biophys Acta 2002; 1602: 114-30.
  • 56
    • 24644483112 scopus 로고    scopus 로고
    • Genomic structure and functional characterization of the human ADAM10 promoter
    • Prinzen C, Muller U, Endres K, Fahrenholz F, Postina R. Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J 2005; 19: 1522-4.
    • (2005) FASEB J , vol.19 , pp. 1522-1524
    • Prinzen, C.1    Muller, U.2    Endres, K.3    Fahrenholz, F.4    Postina, R.5
  • 58
    • 37349009720 scopus 로고    scopus 로고
    • ADAM15 gene structure and differential alternative exon use in human tissues
    • Kleino I, Ortiz RM, Huovila AP. ADAM15 gene structure and differential alternative exon use in human tissues. BMC Mol Biol 2007; 8: 90.
    • (2007) BMC Mol Biol , vol.8 , pp. 90
    • Kleino, I.1    Ortiz, R.M.2    Huovila, A.P.3
  • 59
    • 63649128433 scopus 로고    scopus 로고
    • Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'
    • Murphy G. Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'. Semin Cell Dev Biol 2009; 20: 138-45.
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 138-145
    • Murphy, G.1
  • 60
    • 0141788294 scopus 로고    scopus 로고
    • Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins
    • Shimizu E, Yasui A, Matsuura K, Hijiya N, Higuchi Y, Yamamoto S. Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins. Biochem Biophys Res Commun 2003; 309: 779-85.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 779-785
    • Shimizu, E.1    Yasui, A.2    Matsuura, K.3    Hijiya, N.4    Higuchi, Y.5    Yamamoto, S.6
  • 61
    • 3242769282 scopus 로고    scopus 로고
    • Yasui A, Matsuura K, Shimizu E, Hijiya N, Higuchi Y, Yamamoto S. Expression of splice variants of the human ADAM15 gene and strong interaction between the cytoplasmic domain of one variant and Src family proteins Lck and Hck. Pathobiology 2004; 71: 185-92.
    • Yasui A, Matsuura K, Shimizu E, Hijiya N, Higuchi Y, Yamamoto S. Expression of splice variants of the human ADAM15 gene and strong interaction between the cytoplasmic domain of one variant and Src family proteins Lck and Hck. Pathobiology 2004; 71: 185-92.
  • 62
  • 63
    • 0032724176 scopus 로고    scopus 로고
    • Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE)
    • Milla ME, Leesnitzer MA, Moss ML, Clay WC, Carter HL, Miller AB, et al. Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). J Biol Chem 1999; 274: 30563-70.
    • (1999) J Biol Chem , vol.274 , pp. 30563-30570
    • Milla, M.E.1    Leesnitzer, M.A.2    Moss, M.L.3    Clay, W.C.4    Carter, H.L.5    Miller, A.B.6
  • 64
    • 0032475960 scopus 로고    scopus 로고
    • Intracellular maturation of the mouse metalloprotease disintegrin MDC15
    • Lum L, Reid MS, Blobel CP. Intracellular maturation of the mouse metalloprotease disintegrin MDC15. J Biol Chem 1998; 273: 26236-47.
    • (1998) J Biol Chem , vol.273 , pp. 26236-26247
    • Lum, L.1    Reid, M.S.2    Blobel, C.P.3
  • 66
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge: From protein traffic to embryogenesis and disease
    • Thomas G. Furin at the cutting edge: From protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 2002; 3: 753-66.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 753-766
    • Thomas, G.1
  • 68
    • 34250167944 scopus 로고    scopus 로고
    • Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer
    • Fridman JS, Caulder E, Hansbury M, Liu X, Yang G, Wang Q, et al. Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clin Cancer Res 2007; 13: 1892-902.
    • (2007) Clin Cancer Res , vol.13 , pp. 1892-1902
    • Fridman, J.S.1    Caulder, E.2    Hansbury, M.3    Liu, X.4    Yang, G.5    Wang, Q.6
  • 69
    • 33745802997 scopus 로고    scopus 로고
    • Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab
    • Liu X, Fridman JS, Wang Q, Caulder E, Yang G, Covington M, et al. Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab. Cancer Biol Ther 2006; 5: 648-56.
    • (2006) Cancer Biol Ther , vol.5 , pp. 648-656
    • Liu, X.1    Fridman, J.S.2    Wang, Q.3    Caulder, E.4    Yang, G.5    Covington, M.6
  • 70
    • 33745791118 scopus 로고    scopus 로고
    • Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
    • Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell 2006; 10: 39-50
    • (2006) Cancer Cell , vol.10 , pp. 39-50
    • Zhou, B.B.1    Peyton, M.2    He, B.3    Liu, C.4    Girard, L.5    Caudler, E.6
  • 71
    • 1342323632 scopus 로고    scopus 로고
    • ErbB receptors: Directing key signaling networks throughout life
    • Holbro T, Hynes NE. ErbB receptors: Directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol 2004; 44: 195-217.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 195-217
    • Holbro, T.1    Hynes, N.E.2
  • 72
    • 0036796421 scopus 로고    scopus 로고
    • The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
    • Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, et al. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 2002; 11: 2615-24.
    • (2002) Hum Mol Genet , vol.11 , pp. 2615-2624
    • Hartmann, D.1    de Strooper, B.2    Serneels, L.3    Craessaerts, K.4    Herreman, A.5    Annaert, W.6
  • 73
    • 0035313164 scopus 로고    scopus 로고
    • Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    • Zhao J, Chen H, Peschon JJ, Shi W, Zhang Y, Frank SJ, et al. Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. Dev Biol 2001; 232: 204-18.
    • (2001) Dev Biol , vol.232 , pp. 204-218
    • Zhao, J.1    Chen, H.2    Peschon, J.J.3    Shi, W.4    Zhang, Y.5    Frank, S.J.6
  • 74
    • 0028820623 scopus 로고    scopus 로고
    • Wolfsberg TG, Primakoff P, Myles DG, White JM. ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol 1995; 131: 275-8.
    • Wolfsberg TG, Primakoff P, Myles DG, White JM. ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol 1995; 131: 275-8.
  • 77
    • 0025371355 scopus 로고
    • Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence
    • Blobel CP, Myles DG, Primakoff P, White JM. Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence. J Cell Biol 1990; 111: 69-78.
    • (1990) J Cell Biol , vol.111 , pp. 69-78
    • Blobel, C.P.1    Myles, D.G.2    Primakoff, P.3    White, J.M.4
  • 78
    • 0027431501 scopus 로고
    • The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: Structural, functional, and evolutionary implications
    • Wolfsberg TG, Bazan JF, Blobel CP, Myles DG, Primakoff P, White JM. The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: Structural, functional, and evolutionary implications. Proc Natl Acad Sci USA 1993; 90: 10783-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10783-10787
    • Wolfsberg, T.G.1    Bazan, J.F.2    Blobel, C.P.3    Myles, D.G.4    Primakoff, P.5    White, J.M.6
  • 79
    • 0141533033 scopus 로고    scopus 로고
    • Modulators of cell-cell and cell-matrix interactions
    • White JM. ADAMs: Modulators of cell-cell and cell-matrix interactions. Curr Opin Cell Biol 2003; 15: 598-606.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 598-606
    • White, J.A.1
  • 80
    • 63049110385 scopus 로고    scopus 로고
    • EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2
    • Klessner JL, Desai BV, Amargo EV, Getsios S, Green KJ. EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell 2009; 20: 328-37.
    • (2009) Mol Biol Cell , vol.20 , pp. 328-337
    • Klessner, J.L.1    Desai, B.V.2    Amargo, E.V.3    Getsios, S.4    Green, K.J.5
  • 81
    • 65649119654 scopus 로고    scopus 로고
    • Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays
    • Maretzky T, Yang G, Ouerfelli O, Overall CM, Worpenberg S, Hassiepen U, et al. Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J 2009; 420: 105-13.
    • (2009) Biochem J , vol.420 , pp. 105-113
    • Maretzky, T.1    Yang, G.2    Ouerfelli, O.3    Overall, C.M.4    Worpenberg, S.5    Hassiepen, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.