Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays

Biochemical Journal

Volumn 420, Issue 1, 2009, Pages 105-113

  Maretzky, Thorsten ^a   Yang, Guangli ^b   Querfelli, Ouathek ^b   Overall, Christopher M ^c   Worpenberg, Susanne ^d   Hassiepen, Ulrich ^d   Eder, Joerg ^d   Blobel, Carl P ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

ADAM (a disintegrin and metalloproteinase); ADAM15; Ectodomain shedding; Fibroblast growth factor receptor 2 (FGFR2)

Indexed keywords

ADAM (A DISINTEGRIN AND METALLOPROTEINASE); ADAM15; CALCIUM IONOPHORE; CATALYTIC ACTIVITY; CATALYTIC PROPERTIES; CELL-BASED ASSAYS; ECTODOMAIN SHEDDING; EXTRACELLULAR DOMAINS; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2); HUMAN CANCER; HYDROXAMATE; IN-CELL; INTACT CELLS; MEMBRANE PROTEINS; METALLOPROTEINASE; METALLOPROTEINASES; NEOVASCULARIZATION; OVER-EXPRESSION; PEPTIDE SUBSTRATES; PHORBOL ESTERS; PROSTATE CANCERS; TISSUE INHIBITOR;

AMINES; ASSAYS; BIOACTIVITY; BLOOD VESSELS; CALCIUM; CATALYST ACTIVITY; CELL CULTURE; CELL MEMBRANES; ELECTROCHEMICAL SENSORS; ESTERS; FIBROBLASTS; PEPTIDES; TISSUE;

ENZYME ACTIVITY;

ADAM PROTEIN; ADAM15 PROTEIN; CALCIUM IONOPHORE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; ILOMASTAT; MARIMASTAT; MEMBRANE PROTEIN; PHORBOL ESTER; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; ADAM15 PROTEIN, HUMAN; PEPTIDE LIBRARY;

ANIMAL CELL; ARTICLE; BREAST CANCER; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; MEMBRANE BINDING; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CELL LINE; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOUSE; MUTATION;

ADAM PROTEINS; ANIMALS; CATALYSIS; CELL LINE; MEMBRANE PROTEINS; MICE; MUTATION; PEPTIDE LIBRARY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SUBSTRATE SPECIFICITY;

EID: 65649119654     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082127     Document Type: Article

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