Vipera lebetina venom contains all types of snake venom metalloproteases

Pathophysiology of Haemostasis and Thrombosis

Volumn 34, Issue 4-5, 2006, Pages 209-214

  Siigur, J ^a   Tonismagi K ^a   Trummal, K ^a   Aaspollu A ^a   Samel, M ^a   Vija, H ^a   Subbi, J ^a   Kalkkinen, N ^b   Siigur, E ^a  

^a NATIONAL INSTITUTE OF CHEMICAL PHYSICS AND BIOPHYSICS   (Estonia)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Apoptosis inducing protease; Factor X activator; Fibrino(geno)lytic enzymes; Lebetase; Metalloproteases; Snake venom; Vipera lebetina

Indexed keywords

APOPTOSIS INDUCING PROTEASE; BLOOD CLOTTING FACTOR 10; COMPLEMENTARY DNA; ENZYME; LEBETASE; METALLOPROTEINASE; PROTEINASE; REPROLYSIN; SNAKE VENOM; UNCLASSIFIED DRUG; ZINC ION;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APOPTOSIS; BLOOD CLOTTING; CONFERENCE PAPER; ENDOTHELIUM CELL; ENZYME ACTIVITY; FIBRINOLYSIS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SNAKE; TANDEM MASS SPECTROMETRY; TOXIN ANALYSIS; UMBILICAL VEIN; VIPERA LEBETINA;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CLONING, MOLECULAR; ENDOTHELIUM, VASCULAR; HUMANS; METALLOENDOPEPTIDASES; METALLOPROTEASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE ANALYSIS, PROTEIN; SNAKE VENOMS; UMBILICAL CORD; VIPER VENOMS;

EID: 33646784704     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092426     Document Type: Conference Paper

References (30)

1. Stocker K: Snake venom proteins affecting hemostasis and fibrinolysis: in Stocker K (ed): Medical Use of Snake Venom Proteins. Boca Raton, Ann Arbor, Boston, CRC Press, 1990, pp 97-160.
2. Ouyang C, Teng CM, Huang TF: Characterization of snake venom components acting on blood coagulation and platelet function. Toxicon 1992;30:945-966.
3. Braud S, Bon C, Wisner A: Snake venom proteins acting on hemostasis. Biochimie 2000;82: 851-859.
4. Matsui T, Fujimura Y, Titani K: Snake venom proteases affecting hemostasis and thrombosis. Biochim Biophys Acta 2000;1477:146-156.
5. Siigur E, Siigur J: The direct-acting α-fibrin(ogen)olytic enzymes from snake venoms. J Toxicol Toxin Rev 1992;11:91-113.
6. Kamiguti AS: Platelets as targets of snake venom metalloproteinases. Toxicon 2005;45: 1041-1049.
7. Swenson S, Markland FS: Snake venom fibrin(ogen)olytic enzymes. Toxicon 2005;45: 1021-1039.
8. Bjarnason JB, Fox JW: Hemorrhagic metalloproteinases from snake venoms. Pharmacol Ther 1994;62:325-372.
9. Hite LA, Jia L-G, Bjarnason JB, Fox JW: cDNA sequences for four snake venom metalloproteinases: structure, classification, and their relationship to mammalian reproductive tract proteins. Arch Biochem Biophys 1994; 308:182-191.
10. Bjarnason JB, Fox JW: Snake venom metalloendopeptidases: reprolysins. Methods Enzymol 1995;248:345-368.
11. Siigur E, Aaspollu A, Trummal K, Tonismagi K, Tammiste I, Kalkkinen N, Siigur J: Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochim Biophys Acta 2004;1702:41-51.
12. Fox JW, Serrano SMT: Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 2005;45:969-985.
13. Black RA, White JM: ADAMs: focus on the protease domain. Curr Opin Cell Biol 1998;10: 654-659.
14. Siigur E, Siigur J: Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina (snake) venom. Biochim Biophys Acta 1991;1074:223-229.
15. Siigur J, Siigur E: Lebetase; in Barrett AJ, Rawlings ND, Woessner JF (eds): Handbook of Proteolytic Enzymes, ed 2. London, Elsevier, 2004, pp 707-709.
16. Siigur J, Samel M, Tõnismägi K, Subbi J, Siigur E, Tu AT: Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thromb Res 1998;90:39-49.
17. Siigur E, Aaspôllu A, Tu AT, Siigur J: cDNA cloning and deduced amino acid sequence of fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochem Biophys Res Commun 1996;224:229-236.
18. Calvete JJ, Moreno-Murciano MP, Theakston RDG, Kisiel DG, Marcinkiewicz C: Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem J 2003;372:725-734.
19. Gasmi A, Srairi N, Karoui H, El Ayeb M: Amino acid sequence of VIF: identification in the C-terminal domain of residues common to non-hemorrhagic metalloproteinases from snake venoms. Biochim Biophys Acta 2000; 1481:209-212.
20. Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS Jr, Masiarz FR: Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom. Protein Sci 1992;1:590-600.
21. Trummal K, Tõnismägi K, Siigur E, Aaspõllu A, Lopp A, Sillat T, Saat R, Kasak L, Tammiste I, Kogerman P, Kalkkinen N, Siigur J: A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon 2005;46:46-61.
22. Kishimoto M, Takahashi T: Molecular cloning of HR1a and HR1b, high molecular hemorrhagic factors, from Trimeresurus flavoviridis venom. Toxicon 2002;40:1369-1375.
23. Silva MB, Schattner M, Ramos CRR, Junqueira-De-Azevedo ILM, Guarnieri MC, Lazzari MA, Sampaio CAM, Pozner G, Ventura JS, Ho PL, Chudzinski-Tavassi AM: A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning. Biochem J 2003;369:129-139.
24. Cerretti DP, DuBose RF, Black RA, Nelson N: Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. Biochem Biophys Res Commun 1999;263:810-815.
25. Masuda S, Hayashi H, Atoda H, Morita T, Araki S: Purification, cDNA cloning and characterization of the vascular apoptosis-inducing protein, HV1, from Trimeresurus flavoviridis. Eur J Biochem 2001;268:3339-3345.
26. You WK, Seo HJ, Chung KH, Kim DS: A novel metalloprotease from Gloydius halys venom induces endothelial cell apoptosis through its protease and disintegrin-like domains. J Biochem (Tokyo) 2003;134:739-749.
27. Siigur E, Tõnismägi K, Trummal K, Samel M, Vija H, Subbi J, Siigur J: Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochim Biophys Acta 2001;1568:90-98.
28. Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S: Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains. J Biol Chem 1992;267:14109-14117.
29. Morita T: Proteases which activate factor X; in Bailey GS (ed): Enzymes from Snake Venom. Fort Collins, Colo., Alaken Inc., 1998, pp 179-208.
30. Matsuzaki R, Yoshiara E, Yamada M, Shima K, Atoda H, Morita T: cDNA cloning of IX/X-BP, a heterogeneous two-chain anticoagulant protein from snake venom. Biochem Biophys Res Commun 1996;220:382-387.