Flurbiprofen- and suprofen-dextran conjugates: Synthesis, characterization and biological evaluation

Tropical Journal of Pharmaceutical Research

Volumn 8, Issue 3, 2009, Pages 221-229

  Shrivastava, Sushant K ^a   Jain, D K ^b   Shrivastava, Prabhat K ^a   Trivedi, Piyush ^c  

^a BANARAS HINDU UNIVERSITY   (India)

^b IPS Academy   (India)

^c Rajiv Gandhi Proudyogiki Vishwavidyalaya   (India)

Author keywords

Analgesic antipyretic activity; Dextran conjugates; Flurbiprofen; In vitro hydrolysis; Suprofen

Indexed keywords

ACYLIMIDAZOLE; ANALGESIC AGENT; ANTIPYRETIC AGENT; BUFFER; CARBONYLDIIMIDAZOLE; DEXTRAN; FD 110; FD 40; FD 60; FLURBIPROFEN; IMIDAZOLE DERIVATIVE; SD 110; SD 40; SD 60; SUPROFEN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; DRUG SUBSTITUTION; DRUG SYNTHESIS; HUMAN; HYDROLYSIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; RAT; STOMACH PERFORATION; SWELLING; ULCER; ULCEROGENESIS;

EID: 69249114244     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v8i3.44537     Document Type: Article

References (31)

1. Khandare J, Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Prog Polym Sci 2006; 31; 359-397.
2. Mehvar R, Robinson MA, Reynolds JM. Molecular weight dependent tissue accumulation of dextrans: in vivo studies in rats. J Pharm Sci 1994; 83:1495-1499. (Pubitemid 24315289)
3. Mehvar R. Dextrans for targeted and sustained delivery of therapeutic and imaging agents. J Control Release 2000; 69: 1-25. (Pubitemid 30700409)
4. McLeod AD, Friend DR, Tozer TN. Synthesis and chemical stability of glucocorticoid-dextran esters: potential prodrugs for colon-specific delivery. Int J Pharm 1993; 92:105-114.
5. Harboe E, Johansen M, Larsen C. Macromolecular prodrugs VI. Coupling of the highly lipophilic agent naproxen to dextran and in vitro characterization of the conjugates. Farmaci Sci Ed. 1988; 16:73-85.
6. Lee JS, Jung YJ, Doh MJ, Kim YM. Synthesis and properties of dextran-nalidixic acid ester as a colon-specific prodrug of nalidixic acid. Drug Dev Ind Pharm 2001; 27(4): 331-336. (Pubitemid 32531599)
7. Jung YJ, Lee JS, Kim HH, Kim YT, Kim YM. Synthesis and properties of dextran-5-aminosalicyclic acid ester as a potential colon-specific prodrug of 5-aminosalicyclic acid. Arch Pharmacal Res 1998; 21:179-186. (Pubitemid 128660994)
8. Minami K, Hirayama F, Uekama K. Colon specific drug delivery based on cyclodextrin prodrug: Release behaviour of biphenylyl acetic acid from its cyclodextrin conjugates in rat intestinal tract after oral administration. J Pharm Sci 1998; 87:715-720. (Pubitemid 28268570)
9. Coessens V, Schacht EH, Domurado D. Synthesis and invitro stability of macromolecular prodrug of norfloxacin. J Control Release 1997; 47: 283-291 (Pubitemid 27220211)
10. Won CY, Chu CC. Dextran-estrone conjugate: synthesis and in vitro release study. Carbohydr Polym 1998; 36; 327-334. (Pubitemid 128426915)
11. th Ed.; Hardman, JG, Limbird LE Gilman AL. New York: The McGraw-Hill companies, Inc., 2001. pp. 687-731.
12. Price AH, Fletcher M. Mechanisms of NSAID - Induced Gastroenteropathy. Drugs 1990, pp 1-11.
13. Scherrer RA, Whitehouse MW. Anti-inflammatory agents. New York Academic press, 1974, pp 33.
14. th Ed.; Her Majesty's Stationery Office, London, 1993.
15. Indian Pharmacopoeia, The Controller of Publications, Delhi, 1996.
16. Martindale - The Extra Pharmacopoeia, The Pharmaceutical Press, London, 1989.
17. Otterness IG, Bilven ML. Non-steroidal Antiinflammatory Drugs. In: Lombaridino JG, editor. New York: John Wiley and Sons, Inc., 1985. pp. 11.
18. Brune K. Is there a rational basis for the different spectra of adverse effects of nonsteroidal anti-inflammatory drugs? Drugs 1990; 40: 12-15.
19. Shrivastava SK, Jain DK, Trivedi P. Dextrans - potential polymeric drug carriers for suprofen. Pharmazie 2003; 58: 804-806. (Pubitemid 37462463)
20. Shrivastava SK, Jain DK, Trivedi P. Dextrans - potential polymeric drug carriers for flurbiprofen. Pharmazie 2003: 58: 389-391. (Pubitemid 36733846)
21. Fieser M. In Fieser and Fieser's Reagents for organic synthesis, Wiley-Interscience: New York 1983, pp 155.
22. Schirmer RF. Modern methods of pharmaceutical analysis; CRC Press. Inc.: Boca Raton, Florida 1982, pp 31.
23. st Ed.; Prentice Hall. Inc.: Englewood Cliffs, New Jersey 1992, pp 29.
24. Misra GS. Introductory polymer chemistry. Wiley Eastern Ltd, Ed.1: New Delhi 1993, pp 99.
25. Davies OL. Raventos J, Walpole AL. A method for evaluation of analgesic activity using rats. Br J Pharmacol 1946; 1: 255.
26. Niemegeers CJE, Lenaerts FM, Janssen PAJ. Antipyretic effect of suprofen in rats with yeast - induced fever. A J Drug Res.1975; 25: 1519-1524.
27. Teotino UM, Friz LP, Gandini A, Bella D, Thio D. Derivatives of 2, 3 - dihydro - 4H - 1,3 - benzoxazin - 4 - one. Synthesis and pharmacological properties. J Med Chem 1963; 6: 248-250.
28. Khan MSY, Khan RM. Synthesis and biological evaluation of glycol amide esters as potential prodrugs of some non-steroidal antiinflammatory drugs. Ind J Chem 2002; 14B: 2172-2175.
29. 1 on gastric secretion and ulcer formation in the rat. Gastroenterol 1968; 55 (4): 481-487.
30. th Ed.; John Wiley and Sons, Inc.: New York 1981, pp 95.
31. nd Ed.; John Wiley and Sons, Inc., New York 1958, pp 1.