Synthesis and biological evaluation of glycolamide esters as potential prodrugs of some non-steroidal anti-inflammatory drugs

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Volumn 41, Issue 10, 2002, Pages 2172-2175

  Khan, M S Y ^a   Khan, R M ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; AMIDE; CARRAGEENAN; CHLOROACETAMIDE; DICLOFENAC; IBUPROFEN; INDOMETACIN; MEFENAMIC ACID; N,N DIETHYLCARBAMOYLMETHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 3 INDOLYLACETATE; N,N DIETHYLCARBAMOYLMETHYL 2 (2',3' DIMETHYLPHENYL)AMINOBENZOATE; N,N DIETHYLCARBAMOYLMETHYL 2 (4 ISOBUTYLPHENYL)PROPIONATE; N,N DIETHYLCARBAMOYLMETHYL 2 [(2',6' DICHLOROPHENYL)AMINO]PHENYLACETATE; N,N DIETHYLCARBAMOYLMETHYL 6 METHOXY ALPHA METHYL 2 NAPHTHYLACETATE; N,N DIISOPROPYLCARBAMOYLMETHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 3 INDOLYLACETATE; N,N DIISOPROPYLCARBAMOYLMETHYL 2 (2',3' DIMETHYLPHENYL)AMINOBENZOATE; N,N DIISOPROPYLCARBAMOYLMETHYL 2 (4 ISOBUTYLPHENYL)PROPIONATE; N,N DIISOPROPYLCARBAMOYLMETHYL 2 [(2',6' DICHLOROPHENYL)AMINO]PHENYLACETATE; N,N DIISOPROPYLCARBAMOYLMETHYL 6 METHOXY ALPHA METHYL 2 NAPHTHYLACETATE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; MOUSE; NONHUMAN; PAW EDEMA; POLYMERIZATION; RAT; STOMACH ULCER; ULCEROGENESIS; WRITHING TEST;

EID: 0036816537     PISSN: 03764699     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Langman M J S, Am J Med, 84 (Suppl 2A), 1988, 15.
2. Edelson J T & Tosteson, A N A, JAMA, 264, 1990, 41.
3. Graham D Y, Agarwal N M & Roth S H, Lancet. 337, 1988, 1277.
4. Armstrong C P & Blower A L, Gut, 28, 1987, 527.
5. Hawkey C J, Brit Med Journ, 300, 1990, 278.
6. Silverstein F E, Graham D Y, Senior J R, Davies H W, Struthers B J, Bittman R M & Geis G S, Ann Intertn Med, 123, 1995, 241.
7. Langman M J, Weil J, Wainwright P, Lawson D H, Rawlins M D, Logan R F, Murphy M, Vessey M P & Colin-Jones D G, Lancet, 343, 1994, 1075.
8. Bloom B S, Am J Med, 84 (suppl 2A), 1988, 20.
9. Holzer S S & Cuerdon T, Am J Managed Care, 2, 1996, S15.
10. Bundgaard H & Nielsen N M, J Med Chem, 30, 1987, 451.
11. Nielsen N M & Bundgaard H, J Pharm Sci, 77, 1988, 285.
12. Winter C A, Edwin A R & George W N, Proc Soc Exptl Biol, 3, 1962, 544.
13. Seigmund E, Cadmus R & Lu G, Proc Soc Exp Biol Med, 95, 1957, 729.
14. Wilhemi G & Menass-Gdynia R, Pharmacology, 8, 1972, 321.
15. Harkins E M, US Patent, 3, 173, 900 1965.