Synthesis and properties of dextran-nalidixic acid ester as a colon-specific prodrug of nalidixic acid

Drug Development and Industrial Pharmacy

Volumn 27, Issue 4, 2001, Pages 331-336

  Jeoung Soo Lee, ^a   Yun Jin Jung, ^a   Min Ju Doh, ^a   Young Mi Kim, ^a  

^a Pusan National University   (South Korea)

Author keywords

Colon specific delivery; Colon specific prodrug; Dextran; Dextran nalidixic acid ester; Nalidixic acid

Indexed keywords

2,4 DINITROSALICYLIC ACID; DEXTRAN; DEXTRAN NALIDIXIC ACID ESTER; DEXTRANASE; NALIDIXIC ACID; PRODRUG; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CECUM; COLON; DEPOLYMERIZATION; DOSE RESPONSE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; INTESTINE TRANSIT TIME; MALE; NONHUMAN; PH MEASUREMENT; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTICOAGULANTS; COLON; CULTURE TECHNIQUES; DEXTRANS; DRUG DELIVERY SYSTEMS; ESTERS; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; MALE; NALIDIXIC ACID; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 0035020997     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100103732     Document Type: Article

References (22)

1. Dextran prodrugs for colonic-specific drug delivery
2. An evaluation of pectin as a carrier for drug targeting to the colon
3. Chondroitin sulfate: A potential biodegradable carrier for colon-specific drug delivery
4. Low-molecular-weight azo compounds
5. Development and in vitro/in vivo evaluation of a colonic release capsule of vasopressin
6. Synthesis and evaluation of 5-aminosalicyl-glycine as a potential colon-specific prodrug of 5-aminosalicylic acid
7. Glycosides of 5-aminosalicylic acid
8. Drug glycosides: Potential prodrugs for colon-specific drug delivery
9. Release of 5-aminosalicylic acid from bioadhesive N-(2-hydroxypropyl)methacrylamide copolymers by azoreductases in vitro
10. A polymeric drug for treatment of inflammatory bowel disease
11. An evaluation of pectin as a carrier for drug targeting to the colon
12. Drug therapy of ulcerative colitis
13. Kinetic perspectives in colonic drug delivery
14. Drug absorption in the colon: A critical review
15. Drug absorption from large intestine: Physicochemical factors governing drug absorption
16. Anatomy and physiology of the gastrointestinal tract: Implications for colonic drug delivery
17. Degradation of dextrans by enzymes of intestinal bacteria
18. Dextrans as carriers for drug compounds: Realized and potential applications
19. Determination of pyridonecarboxylic acids in plasma by reverse-phase high-performance liquid chromatography
20. Dextran hydrogels for colon-specific drug delivery. III. In vitro and in vivo degradation
21. Synthesis and chemical stability of glucocorticoid-dextran esters: Potential prodrugs for colon-specific delivery
22. Observations on the flora of the alimentary tract of animals and factors affecting its composition