Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells: Second look at n-3 fatty acid

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 190-195

  Kim, Ji Yoon ^a   Park, Han Deuk ^a   Park, Eunju ^b   Chon, Jeong Woo ^a   Park, Yoo Kyoung ^a  

^a Kyung Hee University   (South Korea)

^b Kyungnam University   (South Korea)

Author keywords

Alpha linolenic acid; Bax; Bcl 2; Breast cancer cells; Caspase 3; Cytochrome c; Poly(ADP ribose) polymerase

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE 3; CYTOCHROME C; ESTROGEN; LINOLENIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OMEGA 3 FATTY ACID; PROTEIN BAX; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BIOACCUMULATION; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRAIN MCF 7; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 69149110149     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04897.x     Document Type: Conference Paper

References (16)

1. Ministry of Health & Welfare. 2003. Annual report of the Korea Central Cancer Registry. Korea Central Cancer Registry Ministry of Health. Seoul, Korea.
2. Hirayama, T. 1978. Epidemiology of breast cancer with special reference to the role of diet. Prev. Med. 7 : 173 195.
3. Wynder, E.L., D.P. Rose L.A. Cohem. 1986. Diet and breast cancer in causation and therapy. Cancer 58 : 1804 1813.
4. Hopkins, G.J., T.G. Kennedy K.K. Carrol. 1981. Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7, 12-dimethylbenz[a]anthracene. J. Natl. Cancer Inst. 66 : 517 522.
5. Escrich, E., M. Solanas, de Villa M.C. Ruiz, et al. 2001. Dietary polyunsaturated n-6 lipids effects on the growth and fatty acid composition of rat mammary tumors. J. Nutr. Biochem. 12 : 536 549.
6. Stripp, C., K. Overvad, J. Christensen, et al. 2003. Fish intake is positively associated with breast cancer incidence rate. J. Nutr. 133 : 3664 3669.
7. Stoll, B.A. 2002. N-3 fatty acids and lipid peroxidation in breast cancer inhibition. Br. J. Nutr. 87 : 193 198.
8. David, J.C., De-Felice. John B. James. 1983. Growth temperature effects on thylakoid membrane lipid and protein content of pea chloroplasts. Plant Physiol. 72 : 225 228.
9. Charles, E.M. Jr. 2000. Omega 3 fatty acids, what's new? Quality herbal products. In Prostate Cancer (Vol. 5, no. 7). Rivanna Health Publications, Inc. Charlottesville, VA.
10. Wu, J. 1996. Apoptosis and angiogenesis: two promising tumor makers in breast cancer (review). Anticancer Res. 16 : 2233 2240.
11. Oltvai, Z.N., C.L. Milliman S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 : 609 619.
12. Reed, J.C. 1995. Regulation of apoptosis by Bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol. 7 : 541 546.
13. Ruvolo, P.P., X. Deng W.S. May. 2001. Phosphorylation of Bcl-2 and regulation of apoptosis. Leukemia 15 : 515 522.
14. Tang, D.G. A.T. Poter. 1997. Target to apoptosis: a hopeful weapon for prostate cancer. Prostate 32 : 284 293.
15. Simstein, R., M. Burow, A. Parker, et al. 2003. Apoptosis, chemoresistance, and breast cancer: insights from the MCF-7 cell model system. Exp. Biol. Med. 228 : 995 1003.
16. Leung, L.K. T.T.Y. Wang. 1999. Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7. Breast Cancer Res. Treat. 55 : 73 83.