15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 457-463

  Cha, Boram ^a   Kim, Kyung Hwan ^a   Kim, Hyeyoung ^a  

^a Yonsei University   (South Korea)

Author keywords

15d PGJ2; Apoptosis; Gastric epithelial cells; Helicobacter pylori; NF B

Indexed keywords

15 DEOXY DELTA 12,14 PROSTAGLANDIN J2; CAGA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

APOPTOSIS; BACTERIAL STRAIN; CELL ACTIVATION; CELL COUNT; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; UPREGULATION; WESTERN BLOTTING;

HELICOBACTER PYLORI;

EID: 69149096920     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04706.x     Document Type: Conference Paper

References (28)

1. Negrini, R., A. Savio, C. Poiesi, et al. 1996. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 111 : 655 665.
2. Nomura, A., G.N. Stemmermann, P.H. Chyou, et al. 1991. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N. Engl. J. Med. 325 : 1132 1136.
3. Lynch, D.A., A.M. Clarke, P. Jackson, et al. 1995. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut 36 : 346 350.
4. + Helicobacter pylori strains. Cancer Res. 61 : 1406 1411.
5. Shirin, H. S.F. Moss. 1998. Helicobacter pylori induced apoptosis. Gut 43 : 592 594.
6. Ahmed, A., D. Smoot, G. Littleton, et al. 2000. Helicobacter pylori inhibits gastric cell cycle progression. Microbes Infect. 2 : 1159 1169.
7. Houghton, J., R.M. Korah, M.R. Condon, et al. 1999. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig. Dis. Sci. 44 : 465 478.
8. Fan, X., H. Gunasena Z. Cheng. 2000. Helicobacter pylori urease binds to Class II MHC on gastric epithelial cells and induces their apoptosis. J. Immunol. 165 : 1918 1924.
9. Lim, J. W., H. Kim K.H. Kim. 2001. NF-κB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection. Free Rad. Biol. Med. 31 : 355 366.
10. Seo, J. H., J.W. Lim, H. Kim K.H. Kim. 2004. Helicobacter pylori in a Korean isolate activates mitogen activated protein kinases, AP-1, and NF-κB and induces chemokine expression in gastric epithelial AGS cells. Lab. Invest. 84 : 49 62.
11. Thanos, D. T. Maniatis. 1995. NF-kappa B: a lesion in family values. Cell 80 : 529 532.
12. Chu, S.H., J.W. Lim, K.H. Kim, et al. 2003. NF-kappaB and Bcl-2 in Helicobacter pylori-induced apoptosis in gastric epithelial cells. Ann. N. Y. Acad. Sci. 1010 : 568 572.
13. Willson, T.M., P.J. Brown, D.D. Sternbach, et al. 2000. The PPARs: from orphan receptors to drug discovery. J. Med.Chem. 43 : 527 550.
14. Kersten, S., B. Desvergne W. Wahli. 2000. Roles of PPARs in health and disease. Nature 405 : 421 424.
15. Tontonoz, P., E. Hu B.M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79 : 1147 1156.
16. Su, C.G., X. Wen, S.T. Bailey, et al. 1999. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J. Clin. Invest. 104 : 383 389.
17. Nakajima, A., K. Wada, H. Miki, et al. 2001. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 120 : 460 469.
18. Straus, D.S. C.K. Glass. 2001. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med. Res. Rev. 21 : 185 210.
19. Hinz, B., K. Brune A. Pahl. 2003. 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma independent mechanism. Biochem. Biophys. Res. Commun. 302 : 415 420.
20. Rossi, A., P. Kapahi, G. Natoli, et al. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403 : 103 108.
21. Kim, J.S., H.S. Jung, J.M. Kim, et al. 1998. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Scan. J. Gastroenterol. 33 : 1249 1255.
22. Kim, J.S., H.S. Jung, J.M. Kim, et al. 2000. Helicobacter pylori water-soluble surface proteins activate human neutrophils and upregulate the expression of CXC chemokines. Dig. Dis. Sci. 45 : 83 92.
23. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 : 248 254.
24. Li, J-J., J.S. Rhim, R. Schlegel, et al. 1998. Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppress anchorage independent growth of HPV immortalized human keratinocytes. Oncogenes 16 : 2711 2721.
25. Seo, J.Y., K.H. Kim H. Kim. 2005. Role of oxidant-sensitive transcription factors on Helicobacter pylori-induced IL-8 expression in gastric epithelial AGS cells. Kor. J. Helicobacter. Upper Gastrointest. Res. 124 133.
26. Jacobson, M. D. 1996. Reactive oxygen species and programmed cell death. Trends Biochem. Sci. 21 : 83 86.
27. Baik, S.C., H.S. Youn, M.H. Chung, et al. 1996. Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. Cancer Res. 56 : 1279 1282.
28. Drake, I.M., N.P. Mapstone, C.J. Schorah, et al. 1998. Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: relation to gastric mucosal ascorbic acid concentrations and effect of H. pylori eradication. Gut 42 : 768 771.