The apoptotic paradox in retinoblastoma

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 77-86

  Sitorus, Rita S ^a,b   Gumay, Saukani ^a   Van Der Valk, Paul ^b  

^a CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Apoptotic index; Bcl 2; Caspase; Caspase 3; Fas receptor; MIB 1; Mitotic index; p53; Proliferation; Retinoblastoma

Indexed keywords

CASPASE 3; FAS ANTIGEN; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; APOPTOTIC INDEX; CELL CYCLE PARAMETERS; CELL PROLIFERATION; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FISHER EXACT TEST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MITOSIS INDEX; PATHOLOGY; PRESCHOOL CHILD; PROTEIN EXPRESSION; RANK SUM TEST; RETINOBLASTOMA; STAINING;

EID: 69149089857     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04719.x     Document Type: Conference Paper

References (48)

1. Krajewski, S., M. Krajewska, B.C. Turner, et al. 1999. Prognostic significance of apoptosis regulators in breast cancer. Endocr. Relat. Cancer 6 : 29 40.
2. de Jong, J.S., P.J. van Diest J.P. Baak. 2000. Number of apoptotic cells as a prognostic marker in invasive breast cancer. Br. J. Cancer 82 : 368 373.
3. Claudio, P.P., A. Zamparelli, F.U. Garcia, et al. 2002. Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin. Cancer Res. 8 : 1808 1815.
4. Heslin, M.J., C. Cordon-Cardo, J.J. Lewis, et al. 1998. Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma. Cancer 83 : 490 497.
5. Mulder, A.H., J.C. Van Hootegem, R. Sylvester, et al. 1992. Prognostic factors in bladder carcinoma: histologic parameters and expression of a cell cycle-related nuclear antigen (Ki-67). J. Pathol. 166 : 37 43.
6. Inman, G.J. M.J. Allday. 2000. Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. J. Immunol. 165 : 2500 2510.
7. Backus, H.H., C.J. Van Groeningen, W. Vos, et al. 2002. Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. J. Clin. Pathol. 55 : 206 211.
8. Nishimura, R., K. Nagao, H. Miyayama, et al. 1999. Apoptosis in breast cancer and its relationship to clinicopathological characteristics and prognosis. J. Surg. Oncol. 71 : 226 234.
9. Cory, S. J.M. Adams. 2002. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2 : 647 656.
10. Green, D.R. G.I. Evan. 2002. A matter of life and death. Cancer Cell. 1 : 19 30.
11. Vaux, D.L. S.J. Korsmeyer. 1999. Cell death in development. Cell 96 : 245 254.
12. Johnstone, R.W., A.A. Ruefli S.W. Lowe. 2002. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108 : 153 164.
13. Fisher, D.E. 1994. Apoptosis in cancer therapy: crossing the threshold. Cell 78 : 539 542.
14. Vaux, D.L. 2002. Apoptosis and toxicology-what relevance? Toxicology 181-182 : 3 7.
15. Rathmell, J.C. C.B. Thompson. 1999. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 17 : 781 828.
16. Simpson, M.T., J.G. MacLaurin, D. Xu, et al. 2001. Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 : 7089 7098.
17. Fattman, C.L., S.M. Delach, Q.P. Dou, et al. 2001. Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene 20 : 2918 2926.
18. Zimmermann, K.C. D.R. Green. 2001. How cells die: apoptosis pathways. J. Allergy. Clin. Immunol. 108 (4 Suppl S99 103.
19. Schwimer, C.J. R.A. Prayson. 2001. Clinicopathologic study of retinoblastoma including MIB-1, p53, and CD99 immunohistochemistry. Ann. Diagn. Pathol. 5 : 148 154.
20. Coupland, S.E., N. Bechrakis, A. Schuler, et al. 1998. Expression patterns of cyclin D1 and related proteins regulating G1-S phase transition in uveal melanoma and retinoblastoma. Br. J. Ophthalmol. 82 : 961 970.
21. Nahle, Z., J. Polakoff, R.V. Davuluri, et al. 2002. Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell. Biol. 4 : 859 864.
22. Fan, G. C.J. Steer. 1999. The role of retinoblastoma protein in apoptosis. Apoptosis 4 : 21 29.
23. Fan, G., X. Ma, B.T. Kren, et al. 2002. Unbound E2F modulates TGF-beta1-induced apoptosis in HuH-7 cells. J. Cell. Sci. 115 (Pt 15 3181 3191.
24. Chau, B.N. J.Y. Wang. 2003. Coordinated regulation of life and death by RB. Nat. Rev. Cancer 3 : 130 138.
25. Wyllie, A.H. 1993. Apoptosis (the 1992 Frank Rose Memorial Lecture). Br. J. Cancer 67 : 205 208.
26. Evan, G., E. Harrington, A. Fanidi, et al. 1994. Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos. Trans. R. Soc. Lond. B Biol. Sci. 345 : 269 275.
27. Evan, G. 2001. The relevance of oncogene-induced apoptosis in cancer. Sci. World J. 1 (1 Suppl 3 89.
28. van Slooten, H.J., M.J. van de Vijver, C.J. van de Velde, et al. 1998. Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity. Br. J. Cancer 77 : 789 796.
29. Cha, S.C., K.S. Suh, K.S. Song, et al. 2000. Cell death in retinoblastoma: electron microscopic, immunohistochemical, and DNA fragmentation studies. Ultrastruct. Pathol. 24 : 23 32.
30. Evan, G.I. K.H. Vousden. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411 : 342 348.
31. Trimarchi, J.M. J.A. Lees. 2002. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell. Biol. 3 : 11 20.
32. Lowe, S.W., E.M. Schmitt, S.W. Smith, et al. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362 : 847 849.
33. Muller, M., C.A. Scaffidi, P.R. Galle, et al. 1998. The role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis. Eur. Cytokine. Netw. 9 : 685 686.
34. Spector, M.S., S. Desnoyers, D.J. Hoeppner, et al. 1997. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385 : 653 656.
35. Newmeyer, D.D., E. Bossy-Wetzel, R.M. Kluck, et al. 2000. Bcl-xL does not inhibit the function of Apaf-1. Cell Death Differ. 7 : 402 407.
36. Adams, J.M. S. Cory 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281 : 1322 1326.
37. Yang, E. S.J. Korsmeyer. 1996. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88 : 386 401.
38. Kroemer, G. 1997. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3 : 614 620.
39. Reed, J.C. 1994. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124 : 1 6.
40. Ashkenazi, A. 2002. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat. Rev. Cancer 2 : 420 430.
41. Strasser, A., A.W. Harris, D.C. Huang, et al. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14 : 6136 6147.
42. Vaux, D.L. A. Strasser 1996. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93 : 2239 2244.
43. Nagata, S. 1996. Fas-mediated apoptosis. Adv. Exp. Med. Biol. 406 : 119 124.
44. Nagata, S. P. Golstein 1995. The Fas death factor. Science 267 : 1449 1456.
45. Tan, X. J.Y. Wang. 1998. The caspase-RB connection in cell death. Trends. Cell. Biol. 8 : 116 120.
46. Janicke, R.U., P.A. Walker, S.Y. Lin, et al. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15 (24 6969 6978.
47. Tan, X., S.J. Martin, D.R. Green, et al. 1997. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death. J. Biol. Chem. 272 (15 9623 9626.
48. Marsden, V.S., L. O'Connor, L.A. O'Reilly, et al. 2002. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419 (6907 634 637.