The role of genetics in delirium in the elderly patient

Dementia and Geriatric Cognitive Disorders

Volumn 28, Issue 3, 2009, Pages 187-195

  Van Munster, Barbara C ^a,b   De Rooij, Sophia E ^b   Korevaar, Johanna C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Delirium, diagnosis; Genetics; Pathophysiology; Review; Risk factors, delirium

Indexed keywords

COGNITION; DELIRIUM; GENE FUNCTION; GENETIC RISK; GENOTYPE; HEALTH CARE COST; HUMAN; MEDICAL RESEARCH; MORTALITY; PHENOTYPE; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW;

AGED; DELIRIUM; GENOTYPE; HUMANS; RESEARCH;

EID: 69149089565     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235796     Document Type: Review

References (52)

1. Michaud L, Bula C, Berney A, Camus V, Voellinger R, Stiefel F, Burnand B: Delirium: guidelines for general hospitals. J Psychosom Res 2007; 62: 371-383.
2. Inouye SK: Delirium in older persons. N Engl J Med 2006; 354: 1157-1165.
3. Maclullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C: Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 2008; 65: 229-238.
4. Gunther ML, Morandi A, Ely EW: Pathophysiology of delirium in the intensive care unit. Crit Care Clin 2008; 24: 45-65.
5. Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK: Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci 2006; 61: 1281-1286.
6. Blacker D, Lovestone S: Genetics and dementia nosology. J Geriatr Psychiatry Neurol 2006; 19: 186-191.
7. Beck AT: The evolution of the cognitive model of depression and its neurobiological correlates. Am J Psychiatry 2008; 165: 969-977.
8. Maier W: Common risk genes for affective and schizophrenic psychoses. Eur Arch Psychiatry Clin Neurosci 2008; 258(suppl 2):37-40.
9. Zuchner S, Roberts ST, Speer MC, Beckham JC: Update on psychiatric genetics. Genet Med 2007; 9: 332-340.
10. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM IV-TR. Washington, American Psychiatric Association, 2000.
11. Meagher DJ, Maclullich AM, Laurila JV: Defining delirium for the International Classification of Diseases, 11th Revision. J Psychosom Res 2008; 65: 207-214.
12. Korevaar JC, van Munster BC, de Rooij SE: Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study. BMC Geriatr 2005; 5: 6.
13. Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, Fisk J: The risk of dementia and death after delirium. Age Ageing 1999; 28: 551-556.
14. Van der Mast RC, Huyse FJ, Rosier PF: Guideline 'Delirium'. Ned Tijdschr Geneeskd 2005; 149: 1027-1032.
15. Inouye SK, Foreman MD, Mion LC, Katz KH, Cooney LM, Jr: Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Arch Intern Med 2001; 161: 2467-2473.
16. Meagher DJ, Trzepacz PT: Motoric subtypes of delirium. Semin Clin Neuropsychiatry 2000; 5: 75-85.
17. Trzepacz PT: Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry 2000; 5: 132-148.
18. Maldonado JR: Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence- based approach to prevention and treatment. Crit Care Clin 2008; 24: 789-856.
19. Alagiakrishnan K, Wiens CA: An approach to drug-induced delirium in the elderly. Postgrad Med J 2004; 80: 388-393.
20. Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmacher T: Cytokine- associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001; 58: 445-452.
21. De Rooij SE, van Munster BC, Korevaar JC, Levi M: Cytokines and acute phase response in delirium. J Psychosom Res 2007; 62: 521-525.
22. Van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, de Rooij SE: Time course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc 2008; 56: 1704-1709.
23. Lewis MC, Barnett SR: Postoperative delirium: the tryptophan dyregulation model. Med Hypotheses 2004; 63: 402-406.
24. Shigeta H, Yasui A, Nimura Y, Machida N, Kageyama M, Miura M, Menjo M, Ikeda K: Postoperative delirium and melatonin levels in elderly patients. Am J Surg 2001; 182: 449-454.
25. Inouye SK, Charpentier PA: Precipitating factors for delirium in hospitalized elderly persons: predictive model and interrelationship with baseline vulnerability. JAMA 1996; 275: 852-857.
26. Bacanu SA, Devlin B, Chowdari KV, DeKosky ST, Nimgaonkar VL, Sweet RA: Heritability of psychosis in Alzheimer disease. Am J Geriatr Psychiatry 2005; 13: 624-627.
27. Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St George-Hyslop P: The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science 2003; 302: 822-826.
28. Baudoin C, Cohen-Solal ME, Beaudreuil J, De Vernejoul MC: Genetic and environmental factors affect bone density variances of families of men and women with osteoporosis. J Clin Endocrinol Metab 2002; 87: 2053-2059.
29. Van Munster BC, Korevaar JC, de Rooij SE, Levi M, Zwinderman AH: Genetic polymorphisms related to delirium tremens: a systematic review. Alcohol Clin Exp Res 2007; 31: 177-184.
30. Abdolmaleky HM, Thiagalingam S, Wilcox M: Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics 2005; 5: 149-160.
31. Olsson T: Activity in the hypothalamic-pituitary- adrenal axis and delirium. Dement Geriatr Cogn Disord 1999; 10: 345-349.
32. Edwards BJ, Haynes C, Levenstien MA, Finch SJ, Gordon D: Power and sample size calculations in the presence of phenotype errors for case/control genetic association studies. BMC Genet 2005; 6: 18.
33. Holt R, Siddiqi N, Young J: The ethics of consent in delirium studies. J Psychosom Res 2008; 65: 283-287.
34. Olde Rikkert MG, van der Vorm A, Burns A, Dekkers W, Robert P, Sartorius N, Selmes J, Stoppe G, Vernooij-Dassen M, Waldemar G: Consensus statement on genetic research in dementia. Am J Alzheimers Dis Other Demen 2008; 23: 262-266.
35. Jorm AF: A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and crossvalidation. Psychol Med 1994; 24: 145-153.
36. Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandharipande P, Laskowitz DT: Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 2007; 35: 112-117.
37. Tagarakis GI, Tsolaki-Tagaraki F, Tsolaki M, Diegeler A, Kazis D, Rouska E, Papassotiropoulos A: The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery. Clin Res Cardiol 2007; 96: 600-603. (Pubitemid 47400815)
38. Tagarakis GI, Tsolaki-Tagaraki F, Tsolaki M, Diegeler A, Tsilimingas NB, Papassotiropoulos A: The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations. Am J Alzheimers Dis Other Demen 2007; 22: 223-228. (Pubitemid 47025522)
39. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR: Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology 2007; 107: 406-411.
40. Adamis D, Treloar A, Martin FC, Gregson N, Hamilton G, Macdonald AJ: APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 2007; 22: 688-694.
41. Van Munster BC, Korevaar JC, de Rooij SE, Levi M, Zwinderman AH: The association between delirium and the apolipoprotein E- 4 allele in the elderly. Psychiatr Genet 2007; 17: 261-266.
42. Van Munster BC, Yazdanpanah M, Tanck MW, de Rooij SE, van de Giessen E, Sijbrands EJ, Zwinderman AH, Korevaar JC: Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. Am J Med Genet B Neuropsychiatr Genet 2009;Mar 23, Epub ahead of print.
43. Adamis D, Macdonald AJ: A review of the association of apolipoprotein E and delirium; in Penfield LR, Nelson RT (eds): Apoprotein Research. Hauppauge, Nova Science Publishers, 2009.
44. Siest G, Pillot T, Regis-Bailly A, Leininger- Muller B, Steinmetz J, Galteau MM, Visvikis S: Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem 1995; 41: 1068-1086.
45. Vasto S, Candore G, Listi F, Balistreri CR, Colonna-Romano G, Malavolta M, Lio D, Nuzzo D, Mocchegiani E, Di BD, Caruso C: Inflammation, genes and zinc in Alzheimer's disease. Brain Res Rev 2008; 58: 96-105.
46. Allen SJ, MacGowan SH, Tyler S, Wilcock GK, Robertson AG, Holden PH, Smith SK, Dawbarn D: Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neurosci Lett 1997; 239: 33-36.
47. Willard LB, Hauss-Wegrzyniak B, Wenk GL: Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats. Neuroscience 1999; 88: 193-200.
48. Lucht M, Barnow S, Schroeder W, Grabe HJ, Rosskopf D, Brummer C, John U, Freyberger HJ, Herrmann FH: Alcohol consumption is associated with an interaction between DRD2 exon 8 A/A genotype and self-directedness in males. Neuropsychobiology 2007; 56: 24-31.
49. Nikolaus S, Antke C, Kley K, Poeppel TD, Hautzel H, Schmidt D, Muller HW: Investigating the dopaminergic synapse in vivo. I. Molecular imaging studies in humans. Rev Neurosci 2007; 18: 439-472. (Pubitemid 351184054)
50. Van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J: Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J Nucl Med 2005; 46: 745-751.
51. Stoltenberg SF, Burmeister M: Recent progress in psychiatric genetics - some hope but no hype. Hum Mol Genet 2000; 9: 927-935.
52. Lango H, Weedon MN: What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? J Intern Med 2008; 263: 16-27.