AnTi-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 415-420

  Hwang, Jin Tack ^a   Lee, Yun Kyoung ^b   Shin, Jang In ^c   Park, Ock Jin ^b  

^a Korea Food Research Institute   (South Korea)

^b Hannam University   (South Korea)

^c Dankook University   (South Korea)

Author keywords

AMPK; Anti inflammatory and anticarcinogenic effects; Apoptosis; Combination treatment of genistein and capsaicin; COX 2

Indexed keywords

ADENYLATE KINASE; CAPSAICIN; CYCLOOXYGENASE 2; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONFERENCE PAPER; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MAMMARY GLAND; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

EID: 69149086351     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04696.x     Document Type: Conference Paper

References (16)

1. Ravindranath, M.H. et al. 2004. Anticancer therapeutic potential of soy isoflavone, genistein. Adv. Exp. Med. Biol. 546 : 121 165.
2. De Lemos, M.L. 2001. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann. Pharmacother. 35 : 1118 1121.
3. Mccue, P. K. Shetty. 2004. Health benefits of soy isoflavonoids and strategies for enhancement: a review. Crit. Rev. Food Sci. Nutr. 44 : 361 367.
4. Michels, K.B. et al. 2007. Diet and breast cancer: a review of the prospective observational studies. Cancer 109 : 2712 2749.
5. Kousidou, O., G.N. Tzanakakis N.K. Karamanos. 2006. Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells. Mini Rev. Med. Chem. 6 : 331 337.
6. Surh, Y.J. 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3 : 768 780.
7. Ji, C. L.J. Marnett. 1992. Oxygen radical-dependent epoxidation of (7S,8S)-dihydroxy-7,8-dihydrobenzo[a]pyrene in mouse skin in vivo. Stimulation by phorbol esters and inhibition by antiinflammatory steroids. J. Biol. Chem. 267 : 17842 17848.
8. Lerebours, F., I. Bieche R. Lidereau. 2005. Update on inflammatory breast cancer. Breast Cancer Res. 7 : 52 58.
9. Perwez Hussain, S. C.C. Harris. 2007. Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 121 : 2373 2380.
10. Fucito, A. et al. 2007. Genetic and epigenetic alterations in breast cancer: what are the perspectives for clinical practice? Int. J. Biochem. Cell Biol.
11. Jones, P.A. S.B. Baylin. 2007. The epigenomics of cancer. Cell 128 : 683 692.
12. Kaminska, B. 2005. MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754 : 253 262.
13. Tanaka, T. et al. 1998. Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes. Cancer Res. 58 : 2550 2556.
14. Mai, Z., G.L. Blackburn J.R. Zhou. 2007. Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis 28 : 1217 1223.
15. Russo, G.L. 2007. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem. Pharmacol. 74 : 533 544.
16. Vinall, R.L. et al. 2007. Combination treatment of prostate cancer cell lines with bioactive soy isoflavones and perifosine causes increased growth arrest and/or apoptosis. Clin. Cancer Res. 13 : 6204 6216.