p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells

Cell Death and Differentiation

Volumn 16, Issue 9, 2009, Pages 1256-1265

  Joseph, B ^a   Andersson, E R ^a   Vlachos, P ^a   Sodersten E ^a   Liu, L ^a   Teixeira, A I ^a   Hermanson, O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CILIARY NEUROTROPHIC FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1C; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR MASH1;

ARTICLE; ASTROCYTE; BINDING SITE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DNA BINDING; EMBRYO DEVELOPMENT; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE LOSS; GENE REPRESSION; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; PRIORITY JOURNAL; TELENCEPHALON; TRANSCRIPTION REGULATION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CILIARY NEUROTROPHIC FACTOR; CYCLIN-DEPENDENT KINASE INHIBITOR P57; HUMANS; NERVE TISSUE PROTEINS; NEURONS; STEM CELLS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 69049120164     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.72     Document Type: Article

References (39)

1. Ohnuma S, Harris WA. Neurogenesis and the cell cycle. Neuron 2003; 40: 199-208.
2. Guillemot F, Molnar Z, Tarabykin V, Stoykova A. Molecular mechanisms of cortical differentiation. Eur J Neurosci 2006; 23: 857-868.
3. Molne M, Studer L, Tabar V, Ting YT, Eiden MV, McKay RD. Early cortical precursors do not undergo LIF-mediated astrocytic differentiation. J Neurosci Res 2000; 59: 301-311.
4. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M et al. DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 2001; 1 749-758.
5. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L et al. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development 2005; 132: 3345-3356.
6. Hermanson O, Jepsen K, Rosenfeld MG. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 2002; 419: 934-939.
7. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007; 450: 415-419.
8. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 2001; 104: 365-376.
9. Kageyama R, Ohtsuka T, Hatakeyama J, Ohsawa R. Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 2005; 306: 343-348.
10. Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol 2004; 16: 700-707.
11. Carey RG, Li B, DiCicco-Bloom E. Pituitary adenylate cyclase activating polypeptide antimitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity. J Neurosci 2002; 22: 1583-1591.
12. Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117: 211-223.
13. Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell 1999; 99: 499-510.
14. Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C et al p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev 2006; 20: 1511-1524.
15. Kippin TE, Martens DJ, van der Kooy D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 2005; 19: 756-767.
16. Durand B, Gao FB, Raff M. Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J 1997; 16: 306-317.
17. Itoh Y, Masuyama N, Nakayama K, Nakayama KI, Gotoh Y. The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J Biol Chem 2007; 282: 390-396.
18. Yan Y, Frisen J, Lee MH, Massague J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 1997; 11 973-983.
19. Gui H, Li S, Matise MP. A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol 2007; 301: 14-26.
20. Joseph B, Wallen-Mackenzie A, Benoit G, Murata T, Joodmardi E, Okret S et al. p57(Kip2) cooperates with Nurr1 in developing dopamine cells. Proc Natl Acad Sci USA 2003; 100: 15619-15624.
21. van Lookeren Campagne M, Gill R. Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax. J Comp Neurol 1998; 397: 181-198.
22. Reynaud EG, Leibovitch MP, Tintignac LA, Pelpel K, Guillier M, Leibovitch SA. Stabilization of MyoD by direct binding to p57(Kip2). J Biol Chem 2000; 275: 18767-18776.
23. Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci USA 1998; 95: 1392-1397.
24. Yun K, Fischman S, Johnson J, Hrabe de Angelis M, Weinmaster G, Rubenstein JL. Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development 2002; 129: 5029-5040.
25. Johe KK, Hazel TG, Muller T, Dugich-Djordjevic MM, McKay RD. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev 1996; 10: 3129-3140.
26. Andersson T, Sodersten E, Duckworth JK, Cascante A, Fritz N, Sacchetti P et al. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J Biol Chem 2009; 284: 3672-3681.
27. Poitras L, Ghanem N, Hatch G, Ekker M. The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer. Development 2007; 134: 1755-1765.
28. Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H et al. p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J Biol Chem 2003; 278: 52919-52923.
29. Vlachos P, Nyman U, Hajji N, Joseph B. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Cell Death Differ 2007; 14: 1497-1507.
30. Hack MA, Sugimori M, Lundberg C, Nakafuku M, Gotz M. Regionalization and fate specification in neurospheres: The role of Olig2 and Pax6. Mol Cell Neurosci 2004; 25: 664-678.
31. Shou J, Rim PC, Calof AL. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor. Nat Neurosci 1999; 2: 339-345.
32. Jia J, Lin M, Zhang L, York JP, Zhang P. The notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol Cell Biol 2007; 27: 7236-7247.
33. Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U et al. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep 2008; 9: 377-383.
34. Park HC, Boyce J, Shin J, Appel B. Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. J Neurosci 2005; 25: 6836-6844.
35. Kessaris N, Fogarty M, Iannarelli P, Grist M, Wegner M, Richardson WD. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 2006; 9: 173-179.
36. Dugas JC, Ibrahim A, Barres BA. A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation. J Neurosci 2007; 27: 6185-6196.
37. Heinen A, Kremer D, Gottle P, Kruse F, Hasse B, Lehmann H et al. The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination. Proc Natl Acad Sci USA 2008; 105: 8748-8753.
38. Petryniak MA, Potter GB, Rowitch DH, Rubenstein JL. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron 2007; 55: 417-433.
39. Miller FD, Gauthier AS. Timing is everything: Making neurons versus glia in the developing cortex. Neuron 2007; 54: 357-369.