Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 1, 2009, Pages 69-75

  Naufal, Z ^a   Kathman, S ^a   Wilson, C ^a  

^a RJ Reynolds Tobacco Co   (United States)

Author keywords

Bayesian; Cancer slope factor; Dose response; Monte Carlo simulation; NNK; Probabilistic; Risk assessment; Tobacco

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARCINOGEN; DRINKING WATER; NITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAYES THEOREM; CANCER INCIDENCE; CANCER MODEL; CANCER RISK; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; LUNG TUMOR; MONTE CARLO METHOD; MOUSE; NONHUMAN; PANCREAS TUMOR; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROBABILITY; RAT; RISK ASSESSMENT; UNCERTAINTY;

ANIMALS; BAYES THEOREM; CARCINOGENICITY TESTS; CARCINOGENS; DECISION SUPPORT TECHNIQUES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; MOUTH NEOPLASMS; NEOPLASMS, EXPERIMENTAL; NITROSAMINES; PANCREATIC NEOPLASMS; RATS; RISK ASSESSMENT; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA; NICOTIANA TABACUM; RATTUS;

EID: 69049105268     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.06.002     Document Type: Article

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