Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 5, 2009, Pages 885-892

  Miyake, Kotaro ^a   Shimada, Mitsuo ^a   Nishioka, Masanori ^a   Sugimoto, Koji ^a   Batmunkh, Erdenebulgan ^a   Uto, Yoshihiro ^a   Nagasawa, Hideko ^b   Hori, Hitoshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antimetastasis; Hypoxic cell; Lymph node metastasis; Radiosensitizer; TX 1877

Indexed keywords

GELATINASE A; GELATINASE B; MATRILYSIN; RADIOSENSITIZING AGENT; TX 1877; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CANCER SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; INCIDENCE; LYMPH NODE METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; RECTUM CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; HUMANS; LYMPHATIC METASTASIS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; NITROIMIDAZOLES; RADIATION-SENSITIZING AGENTS; RATS; RECTAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; X-RAYS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 69049097060     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-0937-5     Document Type: Article

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