Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models

Neurochemical Research

Volumn 34, Issue 10, 2009, Pages 1816-1823

  Weston, Robert M ^a   Subasinghe, Kamani R ^a   Staikopoulos, Vasiliki ^a   Jarrott, Bevyn ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

HFI 1; Mexiletine; Neuropathic pain; Rodent models of neuropathic pain; Sodium channel blockers; Voltage gated sodium channels

Indexed keywords

BATRACHOTOXININ H3; FORMALDEHYDE; HFI 1; MEXILETINE; RADIOLIGAND; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; DRUG UPTAKE; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; LIPOPHILICITY; MALE; NERVE CELL; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; MALE; MEXILETINE; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

RATTUS; RODENTIA;

EID: 69049094867     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-0012-y     Document Type: Article

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