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Volumn 64, Issue 3, 2009, Pages 490-500

Diversity of the tetracycline resistance gene tet (M) and identification of Tn 916- and Tn 5801-like (Tn 6014) transposons in Staphylococcus aureus from humans and animals

Author keywords

Conjugative transposons; Horizontal gene transfer; Mobile elements; TetA(M)

Indexed keywords

BACTERIAL PROTEIN; CEFTIOFUR; CHLORAMPHENICOL; CIPROFLOXACIN; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; METICILLIN; PENICILLIN G; SPECTINOMYCIN; STREPTOMYCIN; SULFAMETHOXAZOLE; TETRACYCLINE RESISTANCE M PROTEIN; TIAMULIN; TRIMETHOPRIM; UNCLASSIFIED DRUG;

EID: 69049084639     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp214     Document Type: Article
Times cited : (57)

References (51)
  • 1
    • 33750126615 scopus 로고    scopus 로고
    • Antimicrobial resistance in staphylococci and streptococci of animal origin
    • Aarestrup FM ed, Washington: ASM
    • Aarestrup FM, Schwarz S. Antimicrobial resistance in staphylococci and streptococci of animal origin. In: Aarestrup FM ed. Antimicrobial Resistance in Bacterial of Animal Origin. Washington: ASM, 2006; 187-212.
    • (2006) Antimicrobial Resistance in Bacterial of Animal Origin , pp. 187-212
    • Aarestrup, F.M.1    Schwarz, S.2
  • 2
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • Chopra I, Roberts M. Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 2001; 65: 232-60.
    • (2001) Microbiol Mol Biol Rev , vol.65 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 3
    • 17144412507 scopus 로고    scopus 로고
    • Update on acquired tetracycline resistance genes
    • Roberts MC. Update on acquired tetracycline resistance genes. FEMS Microbiol Lett 2005; 245: 195-203.
    • (2005) FEMS Microbiol Lett , vol.245 , pp. 195-203
    • Roberts, M.C.1
  • 4
    • 0030009313 scopus 로고    scopus 로고
    • A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium
    • Ridenhour MB, Fletcher HM, Mortensen JE et al. A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium. Plasmid 1996; 35: 71-80.
    • (1996) Plasmid , vol.35 , pp. 71-80
    • Ridenhour, M.B.1    Fletcher, H.M.2    Mortensen, J.E.3
  • 5
    • 0024987730 scopus 로고
    • Gene heterogeneity for tetracycline resistance in Staphylococcus spp
    • Bismuth R, Zilhao R, Sakamoto H et al. Gene heterogeneity for tetracycline resistance in Staphylococcus spp. Antimicrob Agents Chemother 1990; 34: 1611-4.
    • (1990) Antimicrob Agents Chemother , vol.34 , pp. 1611-1614
    • Bismuth, R.1    Zilhao, R.2    Sakamoto, H.3
  • 6
    • 0035131773 scopus 로고    scopus 로고
    • Resistance to tetracycline and distribution of tetracycline resistance genes in European Staphylococcus aureus isolates
    • Schmitz FJ, Krey A, Sadurski R et al. Resistance to tetracycline and distribution of tetracycline resistance genes in European Staphylococcus aureus isolates. J Antimicrob Chemother 2001; 47: 239-40.
    • (2001) J Antimicrob Chemother , vol.47 , pp. 239-240
    • Schmitz, F.J.1    Krey, A.2    Sadurski, R.3
  • 7
    • 0029907697 scopus 로고    scopus 로고
    • Detection of tet(K) and tet(M) in Staphylococcus aureus of Asian countries by the polymerase chain reaction
    • Warsa UC, Nonoyama M, Ida T et al. Detection of tet(K) and tet(M) in Staphylococcus aureus of Asian countries by the polymerase chain reaction. J Antibiot (Tokyo) 1996; 49: 1127-32.
    • (1996) J Antibiot (Tokyo) , vol.49 , pp. 1127-1132
    • Warsa, U.C.1    Nonoyama, M.2    Ida, T.3
  • 8
    • 0031726539 scopus 로고    scopus 로고
    • Tetracycline resistance in Staphylococcus spp. from domestic animals
    • Schwarz S, Roberts MC, Werckenthin C et al. Tetracycline resistance in Staphylococcus spp. from domestic animals. Vet Microbiol 1998; 63: 217-27.
    • (1998) Vet Microbiol , vol.63 , pp. 217-227
    • Schwarz, S.1    Roberts, M.C.2    Werckenthin, C.3
  • 9
    • 69049114941 scopus 로고    scopus 로고
    • Distribution of tet(M) in Gram-positive and Gram-negative bacteria. http://faculty.washington.edu/marilynr/ (23 September 2008, date last accessed).
    • Distribution of tet(M) in Gram-positive and Gram-negative bacteria. http://faculty.washington.edu/marilynr/ (23 September 2008, date last accessed).
  • 10
    • 0036439064 scopus 로고    scopus 로고
    • Conjugative transposons: The tip of the iceberg
    • Burrus V, Pavlovic G, Decaris B et al. Conjugative transposons: the tip of the iceberg. Mol Microbiol 2002; 46: 601-10.
    • (2002) Mol Microbiol , vol.46 , pp. 601-610
    • Burrus, V.1    Pavlovic, G.2    Decaris, B.3
  • 11
    • 0031928701 scopus 로고    scopus 로고
    • 916 family conjugative transposons and dissemination of antimicrobial resistance determinants
    • Rice LB. Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants. Antimicrob Agents Chemother 1998; 42: 1871-7.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1871-1877
    • Rice, L.T.1
  • 12
    • 19444374642 scopus 로고    scopus 로고
    • Conjugation in Gram-positive bacteria
    • Funnell BE, Phillips GJE eds, Washington, DC: American Society for Microbiology
    • Clewell DB, Francia MV. Conjugation in Gram-positive bacteria. In: Funnell BE, Phillips GJE eds. Plasmid Biology. Washington, DC: American Society for Microbiology, 2004; 227-56.
    • (2004) Plasmid Biology , pp. 227-256
    • Clewell, D.B.1    Francia, M.V.2
  • 13
    • 0023158055 scopus 로고
    • 1545: A conjugative shuttle transposon
    • Courvalin P, Carlier C. Tn1545: A conjugative shuttle transposon. Mol Gen Genet 1987; 206: 259-64.
    • (1987) Mol Gen Genet , vol.206 , pp. 259-264
    • Courvalin, P.1    Carlier, C.T.2
  • 14
    • 0035925904 scopus 로고    scopus 로고
    • Whole genome sequencing of methicillin-resistant Staphylococcus aureus
    • Kuroda M, Ohta T, Uchiyama I et al. Whole genome sequencing of methicillin-resistant Staphylococcus aureus. Lancet 2001; 357 1225-40.
    • (2001) Lancet , vol.357 , pp. 1225-1240
    • Kuroda, M.1    Ohta, T.2    Uchiyama, I.3
  • 15
    • 0037304131 scopus 로고    scopus 로고
    • Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: Genomic island SCC
    • Ito T, Okuma K, Ma XX et al. Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: Genomic island SCC. Drug Resist Updat 2003; 6: 41-52.
    • (2003) Drug Resist Updat , vol.6 , pp. 41-52
    • Ito, T.1    Okuma, K.2    Ma, X.X.3
  • 16
    • 0035015178 scopus 로고    scopus 로고
    • Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules
    • Roberts AP, Johanesen PA, Lyras D et al. Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules. Microbiology 2001; 147: 1243-51.
    • (2001) Microbiology , vol.147 , pp. 1243-1251
    • Roberts, A.P.1    Johanesen, P.A.2    Lyras, D.3
  • 17
    • 0029960494 scopus 로고    scopus 로고
    • Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens
    • Lyras D, Rood JI. Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens. Antimicrob Agents Chemother 1996; 40: 2500-4.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2500-2504
    • Lyras, D.1    Rood, J.I.2
  • 18
    • 0030152526 scopus 로고    scopus 로고
    • The tetracycline resistance gene tet(M) exhibits mosaic structure
    • Oggioni MR, Dowson CG, Smith JM et al. The tetracycline resistance gene tet(M) exhibits mosaic structure. Plasmid 1996; 35 156-63.
    • (1996) Plasmid , vol.35 , pp. 156-163
    • Oggioni, M.R.1    Dowson, C.G.2    Smith, J.M.3
  • 19
    • 0033743869 scopus 로고    scopus 로고
    • Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae
    • Doherty N, Trzcinski K, Pickerill P et al. Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae. Antimicrob Agents Chemother 2000; 44: 2979-84.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2979-2984
    • Doherty, N.1    Trzcinski, K.2    Pickerill, P.3
  • 20
    • 1642418322 scopus 로고    scopus 로고
    • Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food
    • Huys G, D'Haene K, Collard JM et al. Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food. Appl Environ Microbiol 2004; 70: 1555-62.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 1555-1562
    • Huys, G.1    D'Haene, K.2    Collard, J.M.3
  • 21
    • 33645834530 scopus 로고    scopus 로고
    • Identification of Tn5397 like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry
    • Agersø Y, Pedersen AG, Aarestrup FM. Identification of Tn5397 like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry. J Antimicrob Chemother 2006; 57: 832-9.
    • (2006) J Antimicrob Chemother , vol.57 , pp. 832-839
    • Agersø, Y.1    Pedersen, A.G.2    Aarestrup, F.M.3
  • 22
    • 0037313590 scopus 로고    scopus 로고
    • Molecular characterization of tet(M) genes in Lactobacillus isolates from different types of fermented dry sausage
    • Gevers D, Danielsen M, Huys G et al. Molecular characterization of tet(M) genes in Lactobacillus isolates from different types of fermented dry sausage. Appl Environ Microbiol 2003; 69: 1270-5.
    • (2003) Appl Environ Microbiol , vol.69 , pp. 1270-1275
    • Gevers, D.1    Danielsen, M.2    Huys, G.3
  • 23
    • 0025930634 scopus 로고
    • Nucleotide sequences specific for Tn1545-like conjugative transposons in pneumococci and staphylococci resistant to tetracycline
    • Poyart-Salmeron C, Trieu-Cuot P, Carlier C et al. Nucleotide sequences specific for Tn1545-like conjugative transposons in pneumococci and staphylococci resistant to tetracycline. Antimicrob Agents Chemother 1991; 35: 1657-60.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1657-1660
    • Poyart-Salmeron, C.1    Trieu-Cuot, P.2    Carlier, C.3
  • 24
    • 0029462072 scopus 로고
    • Staphylococcal and other bacterial species associated with intramammary infections in Danish dairy herds
    • Aarestrup FM, Wegener HC, Rosdahl VT et al. Staphylococcal and other bacterial species associated with intramammary infections in Danish dairy herds. Acta Vet Scand 1995; 36: 475-87.
    • (1995) Acta Vet Scand , vol.36 , pp. 475-487
    • Aarestrup, F.M.1    Wegener, H.C.2    Rosdahl, V.T.3
  • 25
    • 0034640905 scopus 로고    scopus 로고
    • Antimicrobial susceptibility and presence of resistance genes in staphylococci from poultry
    • Aarestrup FM, Agersø Y, Ahrens P et al. Antimicrobial susceptibility and presence of resistance genes in staphylococci from poultry. Vet Microbiol 2000; 74: 353-64.
    • (2000) Vet Microbiol , vol.74 , pp. 353-364
    • Aarestrup, F.M.1    Agersø, Y.2    Ahrens, P.3
  • 26
    • 69049089629 scopus 로고    scopus 로고
    • Multiplex PCR for the detection of the mecA gene. http://www.crl-ar.eu/data/images/meca-pcr_protocol%2006.02.08.pdf (24 September 2008, date last accessed).
    • Multiplex PCR for the detection of the mecA gene. http://www.crl-ar.eu/data/images/meca-pcr_protocol%2006.02.08.pdf (24 September 2008, date last accessed).
  • 27
    • 0034116911 scopus 로고    scopus 로고
    • Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark
    • Aarestrup FM, Agersø Y, Gerner-Smidt P et al. Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn Microbiol Infect Dis 2000; 37: 127-37.
    • (2000) Diagn Microbiol Infect Dis , vol.37 , pp. 127-137
    • Aarestrup, F.M.1    Agersø, Y.2    Gerner-Smidt, P.3
  • 28
    • 69049102916 scopus 로고    scopus 로고
    • Macrogen. http://www.macrogen.com/eng/sequencing/sequence_main.jsp (23 September 2008, date last accessed).
    • Macrogen. http://www.macrogen.com/eng/sequencing/sequence_main.jsp (23 September 2008, date last accessed).
  • 29
    • 0037057118 scopus 로고    scopus 로고
    • The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group
    • Agersø Y, Jensen LB, Givskov M et al. The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group. FEMS Microbiol Lett 2002; 214: 251-6.
    • (2002) FEMS Microbiol Lett , vol.214 , pp. 251-256
    • Agersø, Y.1    Jensen, L.B.2    Givskov, M.3
  • 30
    • 0025189518 scopus 로고
    • Movable genetic elements and antibiotic resistance in enterococci
    • Clewell DB. Movable genetic elements and antibiotic resistance in enterococci. Eur J Clin Microbiol Infect Dis 1990; 9: 90-102.
    • (1990) Eur J Clin Microbiol Infect Dis , vol.9 , pp. 90-102
    • Clewell, D.B.1
  • 31
    • 0031574072 scopus 로고    scopus 로고
    • The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
    • Thompson JD, Gibson TJ, Plewniak F et al. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997; 25: 4876-82.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4876-4882
    • Thompson, J.D.1    Gibson, T.J.2    Plewniak, F.3
  • 32
    • 3242810318 scopus 로고    scopus 로고
    • MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment
    • Kumar S, Tamura K, Nei M. MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 2004; 5: 150-63.
    • (2004) Brief Bioinform , vol.5 , pp. 150-163
    • Kumar, S.1    Tamura, K.2    Nei, M.3
  • 33
    • 0034201441 scopus 로고    scopus 로고
    • EMBOSS: The European Molecular Biology Open Software Suite
    • Rice P, Longden I, Bleasby A. EMBOSS: The European Molecular Biology Open Software Suite. Trends Genet 2000; 16: 276-7.
    • (2000) Trends Genet , vol.16 , pp. 276-277
    • Rice, P.1    Longden, I.2    Bleasby, A.3
  • 34
    • 69049109640 scopus 로고    scopus 로고
    • EMBOSS Pairwise Alignment Algorithms. http://www.ebi.ac.uk/emboss/align/ (23 September 2008, date last accessed).
    • EMBOSS Pairwise Alignment Algorithms. http://www.ebi.ac.uk/emboss/align/ (23 September 2008, date last accessed).
  • 35
    • 69049119006 scopus 로고    scopus 로고
    • spa typing. http://www.seqnet.org/pdf/Ridom_spa_sequencing.pdf (23 September 2008, date last accessed).
    • spa typing. http://www.seqnet.org/pdf/Ridom_spa_sequencing.pdf (23 September 2008, date last accessed).
  • 36
    • 69049092529 scopus 로고    scopus 로고
    • MLST typing. http://saureus.mlst.net/misc/info.aspexperimental (23 September 2008, date last accessed).
    • MLST typing. http://saureus.mlst.net/misc/info.aspexperimental (23 September 2008, date last accessed).
  • 37
    • 69049089628 scopus 로고    scopus 로고
    • Ridom SpaServer. http://spaserver2.ridom.de/mlst.shtml (23 September 2008, date last accessed).
    • Ridom SpaServer. http://spaserver2.ridom.de/mlst.shtml (23 September 2008, date last accessed).
  • 38
    • 0003099645 scopus 로고    scopus 로고
    • MLST database, 23 September, date last accessed
    • Staphylococcus aureus MLST database. http://saureus.mlst.net/ (23 September 2008, date last accessed).
    • (2008) Staphylococcus aureus
  • 39
    • 69049088631 scopus 로고    scopus 로고
    • eBURST. http://eburst.mlst.net/ (28 September 2008, date last accessed).
    • eBURST. http://eburst.mlst.net/ (28 September 2008, date last accessed).
  • 40
    • 0032211890 scopus 로고    scopus 로고
    • Detection of the satA gene and transferability of virginiamycin resistance in Enterococcus faecium from food-animals
    • Hammerum AM, Jensen LB, Aarestrup FM. Detection of the satA gene and transferability of virginiamycin resistance in Enterococcus faecium from food-animals. FEMS Microbiol Lett 1998; 168: 145-51.
    • (1998) FEMS Microbiol Lett , vol.168 , pp. 145-151
    • Hammerum, A.M.1    Jensen, L.B.2    Aarestrup, F.M.3
  • 41
    • 0017683982 scopus 로고
    • Restriction-deficient mutants of Staphylococcus aureus
    • Stobberingh EEWKC. Restriction-deficient mutants of Staphylococcus aureus. J Gen Microbiol 1977; 99: 359-67.
    • (1977) J Gen Microbiol , vol.99 , pp. 359-367
    • EEWKC, S.1
  • 42
    • 0020610320 scopus 로고
    • The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
    • Kreiswirth BN, Lofdahl S, Betley MJ et al. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 1983; 305: 709-12.
    • (1983) Nature , vol.305 , pp. 709-712
    • Kreiswirth, B.N.1    Lofdahl, S.2    Betley, M.J.3
  • 43
    • 36849056449 scopus 로고    scopus 로고
    • Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: An international study
    • Wulf MW, Sørum M, van NA et al. Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study. Clin Microbiol Infect 2008; 14: 29-34.
    • (2008) Clin Microbiol Infect , vol.14 , pp. 29-34
    • Wulf, M.W.1    Sørum, M.2    van, N.A.3
  • 44
    • 53549106603 scopus 로고    scopus 로고
    • Revised nomenclature for transposable genetic elements
    • Roberts AP, Chandler M, Courvalin P et al. Revised nomenclature for transposable genetic elements. Plasmid 2008; 60: 167-73.
    • (2008) Plasmid , vol.60 , pp. 167-173
    • Roberts, A.P.1    Chandler, M.2    Courvalin, P.3
  • 45
    • 33846698251 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe
    • Witte W, Strommenger B, Stanek C et al. Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerg Infect Dis 2007; 13: 255-8.
    • (2007) Emerg Infect Dis , vol.13 , pp. 255-258
    • Witte, W.1    Strommenger, B.2    Stanek, C.3
  • 47
    • 34248529737 scopus 로고    scopus 로고
    • Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs
    • Guardabassi L, Stegger M, Skov R. Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs. Vet Microbiol 2007; 122: 384-6.
    • (2007) Vet Microbiol , vol.122 , pp. 384-386
    • Guardabassi, L.1    Stegger, M.2    Skov, R.3
  • 48
    • 33746631363 scopus 로고    scopus 로고
    • Sau1: A novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages
    • Waldron DE, Lindsay JA. Sau1: A novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. J Bacteriol 2006; 188: 5578-85.
    • (2006) J Bacteriol , vol.188 , pp. 5578-5585
    • Waldron, D.E.1    Lindsay, J.A.2
  • 49
    • 0031566835 scopus 로고    scopus 로고
    • Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    • Hiramatsu K, Aritaka N, Hanaki H et al. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 1997; 350: 1670-3.
    • (1997) Lancet , vol.350 , pp. 1670-1673
    • Hiramatsu, K.1    Aritaka, N.2    Hanaki, H.3
  • 50
    • 0029046947 scopus 로고
    • Unconstrained bacterial promiscuity: The Tn916-Tn1545 family of conjugative transposons
    • Clewell DB, Flannagan SE, Jaworski DD. Unconstrained bacterial promiscuity: The Tn916-Tn1545 family of conjugative transposons. Trends Microbiol 1995; 3: 229-36.
    • (1995) Trends Microbiol , vol.3 , pp. 229-236
    • Clewell, D.B.1    Flannagan, S.E.2    Jaworski, D.D.3
  • 51
    • 0037629629 scopus 로고    scopus 로고
    • Association between phage types and antimicrobial resistance among bovine Staphylococcus aureus from 10 countries
    • Vintov J, Aarestrup FM, Zinn CE et al. Association between phage types and antimicrobial resistance among bovine Staphylococcus aureus from 10 countries. Vet Microbiol 2003; 95: 133-47.
    • (2003) Vet Microbiol , vol.95 , pp. 133-147
    • Vintov, J.1    Aarestrup, F.M.2    Zinn, C.E.3


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