Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet

Atherosclerosis

Volumn 206, Issue 1, 2009, Pages 141-147

  Wiersma, Harmen ^a   Nijstad, Niels ^a   de Boer, Jan Freark ^a   Out, Ruud ^b   Hogewerf, Wytse ^a   Van Berkel, Theo J ^b   Kuipers, Folkert ^a   Tietge, Uwe J F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Abcg1; Bile; Cholesterol; HDL; Hepatocyte; Liver; Liver receptor

Indexed keywords

ABC TRANSPORTER G1; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CHOLESTEROL BILE LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE TARGETING; KNOCKOUT MOUSE; LIVER CELL; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; HYDROCARBONS, FLUORINATED; LIPOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; SULFONAMIDES;

EID: 68949219635     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.02.022     Document Type: Article

References (27)

1. Linsel-Nitschke P., and Tall A.R. HDL as a target in the treatment of atherosclerotic cardiovascular disease. Nat Rev Drug Discov 4 (2005) 193-205
2. Assmann G., and Gotto Jr. A.M. HDL cholesterol and protective factors in atherosclerosis. Circulation 109 (2004) III8-14
3. Lewis G.F. Determinants of plasma HDL concentrations and reverse cholesterol transport. Curr Opin Cardiol 21 (2006) 345-352
4. Duffy D., and Rader D.J. Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport. Circulation 113 (2006) 1140-1150
5. Oram J.F., and Vaughan A.M. ATP-binding cassette cholesterol transporters and cardiovascular disease. Circ Res 99 (2006) 1031-1043
6. Klucken J., Buchler C., Orso E., et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97 (2000) 817-822
7. Wang N., Lan D., Chen W., et al. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci USA 101 (2004) 9774-9779
8. Kennedy M.A., Barrera G.C., Nakamura K., et al. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 1 (2005) 121-131
9. Zhang Y., Da Silva J.R., Reilly M., et al. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 115 (2005) 2870-2874
10. Out R., Hoekstra M., Meurs I., et al. Total body ABCG1 expression protects against early atherosclerotic lesion development in mice. Arterioscler Thromb Vasc Biol 27 (2007) 594-599
11. Basso F., Amar M.J., Wagner E.M., et al. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351 (2006) 398-404
12. Ranalletta M., Wang N., Han S., et al. Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26 (2006) 2308-2315
13. Baldan A., Pei L., Lee R., et al. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26 (2006) 2301-2307
14. Out R., Hoekstra M., Hildebrand R.B., et al. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 26 (2006) 2295-2300
15. Curtiss L.K. Is two out of three enough for ABCG1?. Arterioscler Thromb Vasc Biol 26 (2006) 2175-2177
16. Tarr P.T., and Edwards P.A. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J Lipid Res 49 (2008) 169-182
17. Burgess B.L., Parkinson P.F., Racke M.M., et al. ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. J Lipid Res 49 (2008) 1254-1267
18. Wang N., Ranalletta M., Matsuura F., et al. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol 26 (2006) 1310-1316
19. Kuipers F., Jong M.C., Lin Y., et al. Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E-deficient mouse hepatocytes. J Clin Invest 100 (1997) 2915-2922
20. Tietge U.J.F., Maugeais C., Cain W., et al. Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J Biol Chem 275 (2000) 10077-10084
21. Tietge U.J.F., Nijstad N., Havinga R., et al. Secretory phospholipase A2 (sPLA2) expression in transgenic mice results in increased hepatic SR-BI-mediated selective HDL cholesteryl ester uptake but does not affect biliary cholesterol secretion or gallstone formation. J Lipid Res 49 (2008) 563-571
22. Groen A.K., Bloks V.W., Bandsma R.H., et al. Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL. J Clin Invest 108 (2001) 843-850
23. Singaraja R.R., Van Eck M., Bissada N., et al. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation 114 (2006) 1301-1309
24. Timmins J.M., Lee J.Y., Boudyguina E., et al. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 115 (2005) 1333-1342
25. Cavelier C., Lorenzi I., Rohrer L., et al. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim Biophys Acta 1761 (2006) 655-666
26. Zanlungo S., Rigotti A., and Nervi F. Hepatic cholesterol transport from plasma into bile: implications for gallstone disease. Curr Opin Lipidol 15 (2004) 279-286
27. Goldstein J.L., DeBose-Boyd R.A., and Brown M.S. Protein sensors for membrane sterols. Cell 124 (2006) 35-46