Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates

Chemical Biology and Drug Design

Volumn 74, Issue 3, 2009, Pages 322-326

  Ma, Xiang ^a   Woon, Renee Ser Peng ^a   Ho, Paul Chi Lui ^a   Chui, Wai Keung ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

1,3,5 triazine; Antiproliferative activity; Dihydrofolate reductase inhibitors; Triazaspirodiene

Indexed keywords

1,3,5-TRIAZASPIRO [5.5] UNDECA 1,3 DIENE 2,4 DIAMINE DERIVATIVE; 6,8,10 TRIAZASPIRO [4.5] DECA 6,8 DIENE 7,9 DIAMINE DERIVATIVE; DIAMINE DERIVATIVE; DIAMINO TRIAZASPIRODIENE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; METHOTREXATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; BICYCLO COMPOUNDS; BREAST NEOPLASMS; CATTLE; CELL LINE, TUMOR; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; SPIRO COMPOUNDS; TETRAHYDROFOLATE DEHYDROGENASE;

MAMMALIA;

EID: 68949213091     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00860.x     Document Type: Article

References (18)

1. Blakley R.L., Benkovic S.J., Whitehead V.M. (1984) Folates and Pterins. New York : Wiley.
2. Voet D., Voet J.G., Pratt C.W. (2002) Fundamentals of Biochemistry. Upgrade Edn. New York: John Wiley.
3. Gangjee A., Jain H.D., Kurup S. (2007) Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I. Anticancer Agents Med Chem 7 : 524 542.
4. Gangjee A., Jain H.D., Kurup S. (2008) Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part II. Anticancer Agents Med Chem 8 : 205 231.
5. Kisliuk R.L. (2003) Deaza analogs of folic acid as antitumor agents. Curr Pharm Des 9 : 2615 2625.
6. Kompis I.M., Islam K., Then R.L. (2005) DNA and RNA synthesis: antifolates. Chem Rev 105 : 593 620.
7. McGuire J.J. (2003) Anticancer antifolates: current status and future directions. Curr Pharm Des 9 : 2593 2613.
8. Rosowsky A. (1989) Chemistry and biological activity of antifolates. Prog Med Chem 26 : 1 252.
9. Gorlick R., Goker E., Trippett T., Waltham M., Banerjee D., Bertino J.R. (1996) Intrinsic and acquired resistance to methotrexate in acute leukemia. N Engl J Med 335 : 1041 1048.
10. Shih C., Chen V.J., Gossett L.S., Gates S.B., MacKellar W.C., Habeck L.L., Shackelford K.A. et al. (1997) LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 57 : 1116 1123.
11. Zhou W., Zhang X. (1999) Trybizine hydrochloride. Antitrypanosomal. Drugs Future 24 : 1084 1086.
12. Fry D.W., Jackson R.C. (1987) Biological and biochemical properties of new anticancer folate antagonists. Cancer Metastasis Rev 5 : 251 270.
13. Lee H.K., Chui W.K. (1999) Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates. Bioorg Med Chem 7 : 1255 1262.
14. Blakley R.L. (1995) Eukaryotic dihydrofolate reductase. Adv Enzymol Relat Areas Mol Biol 70 : 23 102.
15. Modest E.J., Levine P. (1956) Chemical and biological studies on 1,2-dihydro-s-triazines. III. Two-component synthesis. J Org Chem 21 : 14 21.
16. Modest E.J. (1956) Chemical and biological studies on 1,2-dihydro-s-triazines./ II. Three-component synthesis. J Org Chem 21 : 1 13.
17. Kurihara M., Rouf A.S., Kansui H., Kagechika H., Okuda H., Miyata N. (2004) Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity. Bioorg Med Chem Lett 14 : 4131 4134.
18. Nygren P., Fridborg H., Csoka K., Sundstrom C., de la Torre M., Kristensen J., Bergh J., Hagberg H., Glimelius B., Rastad J., Thdander B., Larsson R. (1994) Detection of tumor-specific cytotoxic drug activity in vitro using the fluorometric microculture cytotoxicity assay and primary cultures of tumor cells from patients. Int J Cancer 56 : 715 720.