메뉴 건너뛰기




Volumn 5, Issue 3, 1996, Pages 202-208

Pharmacology of new aromatase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; AROMATASE INHIBITOR; FADROZOLE; FORMESTANE; LETROZOLE; PYRIDOGLUTETHIMIDE;

EID: 0030057071     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9776(96)90094-6     Document Type: Conference Paper
Times cited : (89)

References (45)
  • 1
    • 78651047933 scopus 로고
    • Adrenalectomy and oophorectomy in treatment of advanced carcinoma of the breast
    • Huggins C, Dao TL-Y. Adrenalectomy and oophorectomy in treatment of advanced carcinoma of the breast. JAMA 1953; 151: 1388-1394.
    • (1953) JAMA , vol.151 , pp. 1388-1394
    • Huggins, C.1    Dao, T.L.-Y.2
  • 3
    • 0025305715 scopus 로고
    • Postmenopausal estrogen synthesis and metabolism: Alterations caused by aromatase inhibitors used for the treatment of breast cancer
    • Lønning P E, Dowsett M, Powles T J. Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer. J Steroid Biochem 1990; 5: 355-366.
    • (1990) J Steroid Biochem , vol.5 , pp. 355-366
    • Lønning, P.E.1    Dowsett, M.2    Powles, T.J.3
  • 4
    • 0023726485 scopus 로고
    • Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer
    • Lønning P E, Kvinnsland S. Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer. Drugs 1988; 35: 685-710.
    • (1988) Drugs , vol.35 , pp. 685-710
    • Lønning, P.E.1    Kvinnsland, S.2
  • 5
    • 0017691307 scopus 로고
    • Adrenal suppression with aminoglutethimide. II. Differential effects of aminoglutethimide on plasma androstenedione and estrogen levels
    • Samojlik E, Santen R J, Wells S A. Adrenal suppression with aminoglutethimide. II. Differential effects of aminoglutethimide on plasma androstenedione and estrogen levels. J Clin Endocrinol Metab 1977; 45: 480-487.
    • (1977) J Clin Endocrinol Metab , vol.45 , pp. 480-487
    • Samojlik, E.1    Santen, R.J.2    Wells, S.A.3
  • 6
    • 0018217717 scopus 로고
    • Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma
    • Santen R J, Santner S, Davis B, Veldhuis J, Samojlik E, Ruby E. Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma. J Clin Endocrinol Metab 1978; 47: 1257-1265.
    • (1978) J Clin Endocrinol Metab , vol.47 , pp. 1257-1265
    • Santen, R.J.1    Santner, S.2    Davis, B.3    Veldhuis, J.4    Samojlik, E.5    Ruby, E.6
  • 7
    • 0021712326 scopus 로고
    • 4-hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer
    • Coombes R C, Goss P, Dowsett M, Gazet J-C, Brodie A. 4-hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer. Lancet 1984; ii: 1237-1239.
    • (1984) Lancet , vol.2 , pp. 1237-1239
    • Coombes, R.C.1    Goss, P.2    Dowsett, M.3    Gazet, J.-C.4    Brodie, A.5
  • 8
    • 0020078292 scopus 로고
    • Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma
    • Santen R J, Worgul T J, Lipton A, Harvey H, Boucher A. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma. Ann Intern Med 1982; 96: 94-101.
    • (1982) Ann Intern Med , vol.96 , pp. 94-101
    • Santen, R.J.1    Worgul, T.J.2    Lipton, A.3    Harvey, H.4    Boucher, A.5
  • 9
    • 0024595623 scopus 로고
    • Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients
    • Dowsett M, Cunningham D C, Stein R C et al. Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients. Cancer Res 1989; 49: 1306-1312.
    • (1989) Cancer Res , vol.49 , pp. 1306-1312
    • Dowsett, M.1    Cunningham, D.C.2    Stein, R.C.3
  • 10
    • 0025327094 scopus 로고
    • Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients
    • Dowsett M, Stein R C, Mehta A, Coombes R C. Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients. Clin Endocrinol 1990; 32: 623-634.
    • (1990) Clin Endocrinol , vol.32 , pp. 623-634
    • Dowsett, M.1    Stein, R.C.2    Mehta, A.3    Coombes, R.C.4
  • 11
    • 0024419217 scopus 로고
    • In situ oestrone synthesi in normal breast and breast tumour tissue: Effect of treatment with 4-hydroxyandrostenedione
    • Reed M J, Owen A M, Lai L C et al. In situ oestrone synthesi in normal breast and breast tumour tissue: effect of treatment with 4-hydroxyandrostenedione. Int J Cancer 1989; 44: 233-237.
    • (1989) Int J Cancer , vol.44 , pp. 233-237
    • Reed, M.J.1    Owen, A.M.2    Lai, L.C.3
  • 12
    • 0002507276 scopus 로고
    • Importance of intratumour aromatase, and its susceptibility to inhibitors
    • Dowsett M, ed. London: Partenon Publishing Group
    • Miller W R. Importance of intratumour aromatase, and its susceptibility to inhibitors. In: Dowsett M, ed. Aromatase inhibition - then, now and tomorrow. London: Partenon Publishing Group, 1994.
    • (1994) Aromatase Inhibition - Then, Now and Tomorrow
    • Miller, W.R.1
  • 13
    • 0024581375 scopus 로고
    • Separation of urinary metabolites of radiolaballed estrogens in man by HPLC
    • Lønning P E, Skulstad P, Sunde A, Thorsen T. Separation of urinary metabolites of radiolaballed estrogens in man by HPLC. J Steroid Biochem 1989; 32: 91-97.
    • (1989) J Steroid Biochem , vol.32 , pp. 91-97
    • Lønning, P.E.1    Skulstad, P.2    Sunde, A.3    Thorsen, T.4
  • 14
    • 0026090289 scopus 로고
    • Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo
    • Jacobs S, Lønning P E, Haynes B, Griggs L, Dowsett M. Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo. J Enzyme Inhibition 1991; 4: 315-325.
    • (1991) J Enzyme Inhibition , vol.4 , pp. 315-325
    • Jacobs, S.1    Lønning, P.E.2    Haynes, B.3    Griggs, L.4    Dowsett, M.5
  • 15
    • 0029560237 scopus 로고
    • In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in post menopausal patients with breast cancer
    • Dowsett M, Jones A, Johnston SRD, Jacobs S, Trunet P, Smith I E. In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in post menopausal patients with breast cancer. Clin Cancer Res 1995; 1: 1511-1515.
    • (1995) Clin Cancer Res , vol.1 , pp. 1511-1515
    • Dowsett, M.1    Jones, A.2    Johnston, S.R.D.3    Jacobs, S.4    Trunet, P.5    Smith, I.E.6
  • 16
    • 0026698078 scopus 로고
    • The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer
    • MacNeill F A, Jones A L, Jacobs S, Lønning P E, Powles T J, Dowsett M. The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer. Br J Cancer 1992; 66: 692-697.
    • (1992) Br J Cancer , vol.66 , pp. 692-697
    • MacNeill, F.A.1    Jones, A.L.2    Jacobs, S.3    Lønning, P.E.4    Powles, T.J.5    Dowsett, M.6
  • 17
    • 0026639780 scopus 로고
    • The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients
    • Jones A L, MacNeill F, Jacobs S, Lønning P E, Dowsett M, Powles T J. The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients. Eur J Cancer 1992; 28A: 1712-1716.
    • (1992) Eur J Cancer , vol.28 A , pp. 1712-1716
    • Jones, A.L.1    MacNeill, F.2    Jacobs, S.3    Lønning, P.E.4    Dowsett, M.5    Powles, T.J.6
  • 18
    • 0029058421 scopus 로고
    • The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients
    • MacNeill F A, Jacobs S, Dowsett M, Lønning P E, Powles T J. The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients. Cancer Chemother Pharmacol 1995; 36: 249-254.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 249-254
    • MacNeill, F.A.1    Jacobs, S.2    Dowsett, M.3    Lønning, P.E.4    Powles, T.J.5
  • 19
    • 0028275330 scopus 로고
    • Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: Effects on aromatase inhibition and estrogen suppression
    • MacNeill F A, Jacobs S, Lønning P E, Powles T J, Dowsett M. Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and estrogen suppression. Br J Cancer 1994; 69: 1171-1175.
    • (1994) Br J Cancer , vol.69 , pp. 1171-1175
    • MacNeill, F.A.1    Jacobs, S.2    Lønning, P.E.3    Powles, T.J.4    Dowsett, M.5
  • 20
    • 0025793984 scopus 로고
    • The influence of CGS 16949A on peripheral aromatisation in breast cancer patients
    • Lønning P E, Jacobs S, Jones A, Haynes B, Powles T, Dowsett M. The influence of CGS 16949A on peripheral aromatisation in breast cancer patients. Br J Cancer 1991; 63: 789-793.
    • (1991) Br J Cancer , vol.63 , pp. 789-793
    • Lønning, P.E.1    Jacobs, S.2    Jones, A.3    Haynes, B.4    Powles, T.5    Dowsett, M.6
  • 21
    • 0011959284 scopus 로고
    • A randomised, double-blind, multicentre crossover trial to evaluate in vivo inhibition of aromatase by arimidex (ZD 1033) (1 mg and 10 mg PO OD) in postmenopausal women with breast cancer
    • Geisler J, Lønning P E, Dowsett M et al. A randomised, double-blind, multicentre crossover trial to evaluate in vivo inhibition of aromatase by arimidex (ZD 1033) (1 mg and 10 mg PO OD) in postmenopausal women with breast cancer. The Breast 1995; 4: 227.
    • (1995) The Breast , vol.4 , pp. 227
    • Geisler, J.1    Lønning, P.E.2    Dowsett, M.3
  • 22
    • 0028912334 scopus 로고
    • Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patients
    • Lønning P E, Helle S I, Johannessen D C et al. Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patients. Clin Endocrinol 1995; 42: 23-30.
    • (1995) Clin Endocrinol , vol.42 , pp. 23-30
    • Lønning, P.E.1    Helle, S.I.2    Johannessen, D.C.3
  • 24
    • 0028077626 scopus 로고
    • Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer
    • Johnston SRD, Smith I E, Doody D, Jacobs S, Robertshaw H, Dowsett M. Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer. Cancer Res 1994; 54: 5875-5881.
    • (1994) Cancer Res , vol.54 , pp. 5875-5881
    • Johnston, S.R.D.1    Smith, I.E.2    Doody, D.3    Jacobs, S.4    Robertshaw, H.5    Dowsett, M.6
  • 25
    • 0024321399 scopus 로고
    • Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide
    • Lønning P E, Johannessen D C, Thorsen T. Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide. Br J Cancer 1989; 60: 107-111.
    • (1989) Br J Cancer , vol.60 , pp. 107-111
    • Lønning, P.E.1    Johannessen, D.C.2    Thorsen, T.3
  • 26
    • 0029583117 scopus 로고
    • A sensitive assay for measurement of plasma oestrone sulphate in patients on treatment with aromatase inhibitors
    • Lønning P E, Ekse D. A sensitive assay for measurement of plasma oestrone sulphate in patients on treatment with aromatase inhibitors. J Steroid Biochem Molec Biol 1995; 55: 409-412.
    • (1995) J Steroid Biochem Molec Biol , vol.55 , pp. 409-412
    • Lønning, P.E.1    Ekse, D.2
  • 27
    • 0027992634 scopus 로고
    • Effects of fadrozole (COS 16949A) and letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients
    • Demers L M. Effects of fadrozole (COS 16949A) and letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients. Breast Cancer Res Treat 1994; 30: 95-102.
    • (1994) Breast Cancer Res Treat , vol.30 , pp. 95-102
    • Demers, L.M.1
  • 28
    • 85030198617 scopus 로고    scopus 로고
    • Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients: Clinical and endocrine effects
    • In press
    • Geisler J, Johannessen D C, Anker G, Lønning P E. Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients: clinical and endocrine effects. Eur J Cancer. In press.
    • Eur J Cancer
    • Geisler, J.1    Johannessen, D.C.2    Anker, G.3    Lønning, P.E.4
  • 29
    • 0025297861 scopus 로고
    • New endocrine drugs for treatment of advanced breast cancer
    • Lønning P E. New endocrine drugs for treatment of advanced breast cancer. Acta Oncol 1990; 29: 379-386.
    • (1990) Acta Oncol , vol.29 , pp. 379-386
    • Lønning, P.E.1
  • 30
    • 0022357163 scopus 로고
    • Aminoglutethimide in advanced breast cancer: Clinical results of a French multicenter randomised trial comparing 500 mg and 1 g/day
    • Bonneterre J, Coppens H, Mauriac L et al. Aminoglutethimide in advanced breast cancer: Clinical results of a French multicenter randomised trial comparing 500 mg and 1 g/day. Eur J Cancer Clin Oncol 1985; 21: 1153-1158.
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 1153-1158
    • Bonneterre, J.1    Coppens, H.2    Mauriac, L.3
  • 31
    • 0024501357 scopus 로고
    • Low dose aminoglutethimide without hydrocortisone for the treatment of advanced postmenopausal breast cancer
    • Bruning P F, Bonfrer JMG, Hart A A M et al. Low dose aminoglutethimide without hydrocortisone for the treatment of advanced postmenopausal breast cancer. Eur J Cancer Clin Oncol 1989; 25: 369-376.
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 369-376
    • Bruning, P.F.1    Bonfrer, J.M.G.2    Hart, A.A.M.3
  • 32
    • 0025965195 scopus 로고
    • Aminoglutethimide in advanced breast cancer: Plasma levels and clinical results after low and high dose
    • Strocchi E, Camaggi C M, Martoni A et al. Aminoglutethimide in advanced breast cancer: Plasma levels and clinical results after low and high dose. Cancer Chemother Pharmacol 1991; 27:451-455.
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 451-455
    • Strocchi, E.1    Camaggi, C.M.2    Martoni, A.3
  • 33
    • 15844394936 scopus 로고
    • 500 mg versus 1000 mg aminoglutethimide (AG) in advanced breast cancer: 3 years results of an Italian multicentre trial
    • Robustelli GdC. 500 mg versus 1000 mg aminoglutethimide (AG) in advanced breast cancer: 3 years results of an Italian multicentre trial. Eur J Cancer 1991; 27 (Suppl. 2): 69.
    • (1991) Eur J Cancer , vol.27 , Issue.2 SUPPL. , pp. 69
    • Robustelli, Gd.C.1
  • 34
    • 12644306671 scopus 로고
    • Two randomised trials establishing efficacy and tolerability of arimidex (ZD 1033) in the treatment of postmenopausal women with advanced breast cancer (PABP)
    • Jonat W, Buzdar A, Howell A et al. Two randomised trials establishing efficacy and tolerability of arimidex (ZD 1033) in the treatment of postmenopausal women with advanced breast cancer (PABP). Eur J Cancer 1995; 31A (Suppl. 5): 76.
    • (1995) Eur J Cancer , vol.31 A , Issue.5 SUPPL. , pp. 76
    • Jonat, W.1    Buzdar, A.2    Howell, A.3
  • 35
    • 0021926621 scopus 로고
    • Low-dose aminoglutethimide without steroid replacement in the treatment of postmenopausal women with advanced breast cancer
    • Murray R, Pitt P. Low-dose aminoglutethimide without steroid replacement in the treatment of postmenopausal women with advanced breast cancer. Eur J Cancer Clin Oncol 1985; 21: 19-22.
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 19-22
    • Murray, R.1    Pitt, P.2
  • 36
    • 0026564338 scopus 로고
    • Influence of aminoglutethimide on plasma estrogen levels in breast cancer patients on 4-hydroxyandrostenedione treatment
    • Lønning P E, Dowsett M, Jones A et al. Influence of aminoglutethimide on plasma estrogen levels in breast cancer patients on 4-hydroxyandrostenedione treatment. Breast Cancer Res Treat 1992; 23: 57-62.
    • (1992) Breast Cancer Res Treat , vol.23 , pp. 57-62
    • Lønning, P.E.1    Dowsett, M.2    Jones, A.3
  • 37
    • 0021338872 scopus 로고
    • Suppression of residual estrogen production with aminoglutethimide in women following surgical hypophysectomy or adrenalectomy
    • Samojlik E, Santen R J, Worgul T J. Suppression of residual estrogen production with aminoglutethimide in women following surgical hypophysectomy or adrenalectomy. Clin Endocrinol 1984; 20: 43-51.
    • (1984) Clin Endocrinol , vol.20 , pp. 43-51
    • Samojlik, E.1    Santen, R.J.2    Worgul, T.J.3
  • 38
    • 0026722827 scopus 로고
    • Aromatisation inhibition alone or in combination with GmRH agonists for the treatment of premenopausal breast cancer patients
    • Dowsett M, Stein R C, Coombes R C. Aromatisation inhibition alone or in combination with GmRH agonists for the treatment of premenopausal breast cancer patients. J Steroid Biochem Molec Biol 1992; 43: 155-159.
    • (1992) J Steroid Biochem Molec Biol , vol.43 , pp. 155-159
    • Dowsett, M.1    Stein, R.C.2    Coombes, R.C.3
  • 39
    • 0029031797 scopus 로고
    • Aromatase inhibition with 4-OH androstenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer
    • Murray R, Pitt P. Aromatase inhibition with 4-OH androstenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer. Breast Cancer Res Treat 1995; 35: 249-253.
    • (1995) Breast Cancer Res Treat , vol.35 , pp. 249-253
    • Murray, R.1    Pitt, P.2
  • 41
    • 0027996965 scopus 로고
    • Analysis of the aromatase cytochrome P450 gene in human breast cancers
    • Sourdaine P, Parker M G, Telford J, Miller W R. Analysis of the aromatase cytochrome P450 gene in human breast cancers. J Mol Endocrinol 1994; 13: 331-337.
    • (1994) J Mol Endocrinol , vol.13 , pp. 331-337
    • Sourdaine, P.1    Parker, M.G.2    Telford, J.3    Miller, W.R.4
  • 42
    • 0028853923 scopus 로고
    • Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells
    • Masamura S, Santner S J, Heitjan F, Santen R J. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J Clin Endocinol Metab 1995; 80: 2918-2925.
    • (1995) J Clin Endocinol Metab , vol.80 , pp. 2918-2925
    • Masamura, S.1    Santner, S.J.2    Heitjan, F.3    Santen, R.J.4
  • 43
    • 0026075029 scopus 로고
    • Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissue
    • Reed M J, Aherne G W, Ghilchik M W, Patel S, Chakraborty J. Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissue. Int J Cancer 1991; 49: 562-565.
    • (1991) Int J Cancer , vol.49 , pp. 562-565
    • Reed, M.J.1    Aherne, G.W.2    Ghilchik, M.W.3    Patel, S.4    Chakraborty, J.5
  • 44
    • 0021931084 scopus 로고
    • Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue
    • Van Landeghem A A J, Poortman J, Nabuurs M, Thijssen J H H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue. Cancer Res 1985; 45: 2900-2904.
    • (1985) Cancer Res , vol.45 , pp. 2900-2904
    • Van Landeghem, A.A.J.1    Poortman, J.2    Nabuurs, M.3    Thijssen, J.H.H.4
  • 45
    • 0011095199 scopus 로고
    • Design and conduct of clinical trials
    • De Vita V T, Hellman S, Rosenberg S, eds. Philadelphia: Lippincott
    • Simon M. Design and conduct of clinical trials. In: De Vita V T, Hellman S, Rosenberg S, eds. Cancer: Principles and Practice of Oncology. Philadelphia: Lippincott, 1985: 329-350.
    • (1985) Cancer: Principles and Practice of Oncology , pp. 329-350
    • Simon, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.