Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia

Atherosclerosis

Volumn 206, Issue 1, 2009, Pages 109-118

  Ishii, Masakazu ^a   Numaguchi, Yasushi ^a,b   Okumura, Kenji ^a,b   Kubota, Ryuji ^b   Ma, Xiuyang ^a   Murakami, Ryuichiro ^b   Naruse, Keiji ^c   Murohara, Toyoaki ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Cell therapy; Hindlimb ischemia; Mesenchymal stem cell; Prostacyclin

Indexed keywords

CYCLOOXYGENASE 2; GREEN FLUORESCENT PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROSTACYCLIN SYNTHASE; PROTEIN BCL 2; PROTEIN KINASE B;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL BASED GENE THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LIMB ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; GENE THERAPY; HINDLIMB; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; PPAR DELTA;

EID: 68949198927     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.02.023     Document Type: Article

References (26)

1. Norgren L., Hiatt W.R., Dormandy J.A., et al., TASC II Working Group. Inter-society consensus for the management of peripheral arterial disease. Int Angiol 26 2 (2007) 81-157
2. Shintani S., Murohara T., Ikeda H., et al. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 103 6 (2001) 897-903
3. Tateishi-Yuyama E., Matsubara H., Murohara T., et al., Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360 9331 (2002) 427-435
4. Miyamoto K., Nishigami K., Nagaya N., et al. Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114 24 (2006) 2679-2684
5. Kinnaird T., Stabile E., Burnett M.S., et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94 5 (2004) 678-685
6. Tateno K., Minamino T., Toko H., et al. Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res 98 9 (2006) 1194-1202
7. Moncada S., and Vane J.R. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin. Pharmacol Rev 30 (1979) 293-331
8. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 299 (1980) 373-376
9. Lam J.Y.T., Chesebro J.H., Badimon L., and Fuster V. Exogenous prostacyclin decreases vasoconstriction but not platelet thrombus deposition after arterial injury. J Am Coll Cardiol 21 (1993) 488-492
10. Santhanam A.V., Smith L.A., He T., Nath K.A., and Katusic Z.S. Endothelial progenitor cells stimulate cerebrovascular production of prostacyclin by paracrine activation of cyclooxygenase-2. Circ Res 100 9 (2007) 1243-1245
11. He T., Lu T., d'Uscio L.V., et al. Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res 103 1 (2008) 80-88
12. Hiraoka K., Koike H., Yamamoto S., et al. Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Circulation 108 21 (2003) 2689-2696
13. Kinnaird T., Stabile E., Burnett M.S., et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109 12 (2004) 1543-1549
14. Iwase T., Nagaya N., Fujii T., et al. Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia. Cardiovasc Res 66 3 (2005) 543-551
15. Gnecchi M., He H., Noiseux N., et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20 6 (2006) 661-669
16. Imai H., Numaguchi Y., Ishii M., et al. Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPARdelta expression. Atherosclerosis 195 (2007) 323-332
17. Numaguchi Y., Naruse K., Harada M., et al. Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. Arterioscler Thromb Vasc Biol 19 (1999) 727-733
18. Yokouchi K., Numaguchi Y., Kubota R., et al. l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty. Arterioscler Thromb Vasc Biol 26 10 (2006) 2231-2237
19. Ishii M., Koike C., Igarashi A., et al. Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts. Biochem Biophys Res Commun 332 1 (2005) 297-303
20. Flusberg D.A., Numaguchi Y., and Ingber D.E. Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol Biol Cell 12 10 (2001) 3087-3094
21. Inoue N., Kondo T., Kobayashi K., et al. Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes. Arterioscler Thromb Vasc Biol 27 1 (2007) 99-105
22. Couffinhal T., Silver M., Zheng L.P., et al. Mouse model of angiogenesis. Am J Pathol 152 (1998) 1667-1679
23. Mangi A.A., Noiseux N., Kong D., et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9 (2003) 1195-1201
24. Li W., Ma N., Ong L.L., et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 25 (2007) 2118-2127
25. Tongers J., Roncalli J.G., and Losordo D.W. Therapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age. Circulation 118 1 (2008) 9-16
26. Piqueras L., Reynolds A.R., Hodivala-Dilke K.M., et al. Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol 27 1 (2007) 63-69