메뉴 건너뛰기




Volumn 19, Issue 4, 2009, Pages 201-208

Mutation screening of the glutamate cysteine ligase modifier (GCLM) gene in patients with schizophrenia

Author keywords

Glutamate cysteine ligase modifier; Glutathione; Mutation; Oxidative stress; Schizophrenia

Indexed keywords

DNA; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

EID: 68949175496     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32832cef21     Document Type: Article
Times cited : (8)

References (53)
  • 2
    • 28144444187 scopus 로고    scopus 로고
    • Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    • Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, et al. (2005). Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet 77:937-944.
    • (2005) Am J Hum Genet , vol.77 , pp. 937-944
    • Arinami, T.1    Ohtsuki, T.2    Ishiguro, H.3    Ujike, H.4    Tanaka, Y.5    Morita, Y.6
  • 3
    • 26044478685 scopus 로고    scopus 로고
    • Schizophrenia: An update and review
    • Austin J (2005). Schizophrenia: an update and review. J Genet Couns 14:329-340.
    • (2005) J Genet Couns , vol.14 , pp. 329-340
    • Austin, J.1
  • 4
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 5
    • 33744802393 scopus 로고    scopus 로고
    • Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia
    • Cabungcal JH, Nicolas D, Kraftsik R, Cuenod M, Do KQ, Hornung JP (2006). Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: relevance to schizophrenia. Neurobiol Dis 22:624-637.
    • (2006) Neurobiol Dis , vol.22 , pp. 624-637
    • Cabungcal, J.H.1    Nicolas, D.2    Kraftsik, R.3    Cuenod, M.4    Do, K.Q.5    Hornung, J.P.6
  • 6
    • 34248589104 scopus 로고    scopus 로고
    • Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: Relevance to schizophrenia.
    • Cabungcal JH, Preissmann D, Delseth C, Cuenod M, Do KQ, Schenk F (2007). Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: relevance to schizophrenia. Neurobiol Dis 26:634-645.
    • (2007) Neurobiol Dis , vol.26 , pp. 634-645
    • Cabungcal, J.H.1    Preissmann, D.2    Delseth, C.3    Cuenod, M.4    Do, K.Q.5    Schenk, F.6
  • 8
    • 1642497596 scopus 로고    scopus 로고
    • Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: Relevance to schizophrenia
    • Castagne V, Rougemont M, Cuenod M, Do KQ (2004). Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. Neurobiol Dis 15:93-105.
    • (2004) Neurobiol Dis , vol.15 , pp. 93-105
    • Castagne, V.1    Rougemont, M.2    Cuenod, M.3    Do, K.Q.4
  • 9
    • 0033793205 scopus 로고    scopus 로고
    • Redox modulation of the NMDA receptor
    • Choi YB, Lipton SA (2000). Redox modulation of the NMDA receptor. Cell Mol Life Sci 57:1535-1541.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1535-1541
    • Choi, Y.B.1    Lipton, S.A.2
  • 10
    • 0030792637 scopus 로고    scopus 로고
    • Multiple roles of glutathione in the central nervous system
    • Cooper AJ, Kristal BS (1997). Multiple roles of glutathione in the central nervous system. Biol Chem 378:793-802.
    • (1997) Biol Chem , vol.378 , pp. 793-802
    • Cooper, A.J.1    Kristal, B.S.2
  • 11
    • 0034908554 scopus 로고    scopus 로고
    • Nomenclature for the description of human sequence variations
    • Den Dunnen JT, Antonarakis SE (2001). Nomenclature for the description of human sequence variations. Hum Genet 109:121-124.
    • (2001) Hum Genet , vol.109 , pp. 121-124
    • Den Dunnen, J.T.1    Antonarakis, S.E.2
  • 12
  • 14
    • 0037163092 scopus 로고    scopus 로고
    • Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence.
    • Erickson AM, Nevarea Z, Gipp JJ, Mulcahy RT (2002). Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence. J Biol Chem 277:30730-30737.
    • (2002) J Biol Chem , vol.277 , pp. 30730-30737
    • Erickson, A.M.1    Nevarea, Z.2    Gipp, J.J.3    Mulcahy, R.T.4
  • 16
    • 0030670301 scopus 로고    scopus 로고
    • Regulation of human gamma-glutamylcysteine synthetase: Co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells.
    • Galloway DC, Blake DG, Shepherd AG, McLellan LI (1997). Regulation of human gamma-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells. Biochem J 328 (Pt 1):99-104.
    • (1997) Biochem J , vol.328 , Issue.PART 1 , pp. 99-104
    • Galloway, D.C.1    Blake, D.G.2    Shepherd, A.G.3    McLellan, L.I.4
  • 18
    • 36749104268 scopus 로고    scopus 로고
    • Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
    • Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P, et al. (2007). Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence. Proc Natl Acad Sci U S A 104:16621-16626.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16621-16626
    • Gysin, R.1    Kraftsik, R.2    Sandell, J.3    Bovet, P.4    Chappuis, C.5    Conus, P.6
  • 19
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B (1992). Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623.
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 20
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence.
    • image 45
    • Harrison PJ, Weinberger DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40-68; image 45.
    • (2005) Mol Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 21
    • 0035133525 scopus 로고    scopus 로고
    • Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia.
    • Herken H, Uz E, Ozyurt H, Sogut S, Virit O, Akyol O (2001). Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia. Mol Psychiatry 6:66-73.
    • (2001) Mol Psychiatry , vol.6 , pp. 66-73
    • Herken, H.1    Uz, E.2    Ozyurt, H.3    Sogut, S.4    Virit, O.5    Akyol, O.6
  • 22
    • 0027171195 scopus 로고
    • Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.
    • Huang CS, Chang LS, Anderson ME, Meister A (1993). Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem 268:19675-19680.
    • (1993) J Biol Chem , vol.268 , pp. 19675-19680
    • Huang, C.S.1    Chang, L.S.2    Anderson, M.E.3    Meister, A.4
  • 23
    • 0032577925 scopus 로고    scopus 로고
    • Hammerhead ribozymes against gamma-glutamylcysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells.
    • Kijima H, Tsuchida T, Kondo H, Iida T, Oshika Y, Nakamura M, et al. (1998). Hammerhead ribozymes against gamma-glutamylcysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells. Biochem Biophys Res Commun 247:697-703.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 697-703
    • Kijima, H.1    Tsuchida, T.2    Kondo, H.3    Iida, T.4    Oshika, Y.5    Nakamura, M.6
  • 24
    • 0029923725 scopus 로고    scopus 로고
    • Free radical pathology and antioxidant defense in schizophrenia: A review
    • MahadikSP, MukherjeeS (1996). Free radical pathology and antioxidant defense in schizophrenia: a review. Schizophr Res 19:1-17.
    • (1996) Schizophr Res , vol.19 , pp. 1-17
    • Mahadik, S.P.1    Mukherjee, S.2
  • 25
    • 58849096261 scopus 로고    scopus 로고
    • Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population.
    • Matsuzawa D, Hashimoto K, Hashimoto T, Shimizu E, Watanabe H, Fujita Y, et al. (2008a). Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 150B:86-94.
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.150 B , pp. 86-94
    • Matsuzawa, D.1    Hashimoto, K.2    Hashimoto, T.3    Shimizu, E.4    Watanabe, H.5    Fujita, Y.6
  • 26
    • 44849102210 scopus 로고    scopus 로고
    • Negative correlation between brain glutathione level and negative symptoms in schizophrenia: A 3T 1H-MRS study.
    • Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, et al. (2008b). Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study. PLoS ONE 3:e1944.
    • (2008) PLoS ONE , vol.3
    • Matsuzawa, D.1    Obata, T.2    Shirayama, Y.3    Nonaka, H.4    Kanazawa, Y.5    Yoshitome, E.6
  • 27
    • 0029197657 scopus 로고
    • Glutathione biosynthesis and its inhibition.
    • Meister A (1995). Glutathione biosynthesis and its inhibition. Methods Enzymol 252:26-30.
    • (1995) Methods Enzymol , vol.252 , pp. 26-30
    • Meister, A.1
  • 29
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells.
    • Miller SA, Dykes DD, Polesky HF (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 30
    • 0032126145 scopus 로고    scopus 로고
    • Expression and purification of human gamma-glutamylcysteine synthetase.
    • Misra I, Griffith OW (1998). Expression and purification of human gamma-glutamylcysteine synthetase. Protein Expr Purif 13:268-276.
    • (1998) Protein Expr Purif , vol.13 , pp. 268-276
    • Misra, I.1    Griffith, O.W.2
  • 31
    • 2642671110 scopus 로고    scopus 로고
    • An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site.
    • Moinova HR, Mulcahy RT (1998). An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. J Biol Chem 273:14683-14689.
    • (1998) J Biol Chem , vol.273 , pp. 14683-14689
    • Moinova, H.R.1    Mulcahy, R.T.2
  • 32
    • 0037172653 scopus 로고    scopus 로고
    • Polymorphism in the 50-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
    • Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, et al. (2002). Polymorphism in the 50-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 105:2968-2973.
    • (2002) Circulation , vol.105 , pp. 2968-2973
    • Nakamura, S.1    Kugiyama, K.2    Sugiyama, S.3    Miyamoto, S.4    Koide, S.5    Fukushima, H.6
  • 33
    • 0141615873 scopus 로고    scopus 로고
    • Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function
    • DOI 10.1161/01.CIR.0000091255.63645.98
    • Nakamura S, Sugiyama S, Fujioka D, Kawabata K, Ogawa H, Kugiyama K (2003). Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function. Circulation 108:1425-1427. (Pubitemid 37176445)
    • (2003) Circulation , vol.108 , Issue.12 , pp. 1425-1427
    • Nakamura, S.-I.1    Sugiyama, S.2    Fujioka, D.3    Kawabata, K.-I.4    Ogawa, H.5    Kugiyama, K.6
  • 35
    • 0842329756 scopus 로고    scopus 로고
    • The molecular genetics of schizophrenia: New findings promise new insights.
    • Owen MJ, Williams NM, O'Donovan MC (2004). The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry 9:14-27.
    • (2004) Mol Psychiatry , vol.9 , pp. 14-27
    • Owen, M.J.1    Williams, N.M.2    O'Donovan, M.C.3
  • 37
    • 0032817577 scopus 로고    scopus 로고
    • Diagnostic interview for genetic studies (DIGS): Inter-rater and test-retest reliability of the French version.
    • Preisig M, Fenton BT, Matthey ML, Berney A, Ferrero F (1999). Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 249:174-179.
    • (1999) Eur Arch Psychiatry Clin Neurosci , vol.249 , pp. 174-179
    • Preisig, M.1    Fenton, B.T.2    Matthey, M.L.3    Berney, A.4    Ferrero, F.5
  • 38
    • 0029038960 scopus 로고
    • Predicting Pol II promoter sequences using transcription factor binding sites.
    • Prestridge DS (1995). Predicting Pol II promoter sequences using transcription factor binding sites. J Mol Biol 249:923-932.
    • (1995) J Mol Biol , vol.249 , pp. 923-932
    • Prestridge, D.S.1
  • 39
    • 0033646792 scopus 로고    scopus 로고
    • Genetic heterogeneity in schizophrenia: Stratification of genome scan data using co-segregating related phenotypes.
    • Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin JL, Dombroski B, et al. (2000). Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 5:650-653.
    • (2000) Mol Psychiatry , vol.5 , pp. 650-653
    • Pulver, A.E.1    Mulle, J.2    Nestadt, G.3    Swartz, K.L.4    Blouin, J.L.5    Dombroski, B.6
  • 40
    • 0034740227 scopus 로고    scopus 로고
    • Application of a time-delay neural network to promoter annotation in the Drosophila melanogaster genome.
    • Reese MG (2001). Application of a time-delay neural network to promoter annotation in the Drosophila melanogaster genome. Comput Chem 26:51-56.
    • (2001) Comput Chem , vol.26 , pp. 51-56
    • Reese, M.G.1
  • 42
    • 33744458952 scopus 로고    scopus 로고
    • Molecular genetic studies of schizophrenia
    • Riley B, Kendler KS (2006). Molecular genetic studies of schizophrenia. Eur J Hum Genet 14:669-680.
    • (2006) Eur J Hum Genet , vol.14 , pp. 669-680
    • Riley, B.1    Kendler, K.S.2
  • 49
    • 30144435733 scopus 로고    scopus 로고
    • Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia
    • Steullet P, Neijt HC, Cuenod M, Do KQ (2006). Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia. Neuroscience 137:807-819.
    • (2006) Neuroscience , vol.137 , pp. 807-819
    • Steullet, P.1    Neijt, H.C.2    Cuenod, M.3    Do, K.Q.4
  • 50
    • 33748676111 scopus 로고    scopus 로고
    • Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene.
    • Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F, et al. (2006). Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 79:586-592.
    • (2006) Am J Hum Genet , vol.79 , pp. 586-592
    • Tosic, M.1    Ott, J.2    Barral, S.3    Bovet, P.4    Deppen, P.5    Gheorghita, F.6
  • 52
    • 0037147240 scopus 로고    scopus 로고
    • Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response
    • Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP (2002). Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem 277:49446-49452.
    • (2002) J Biol Chem , vol.277 , pp. 49446-49452
    • Yang, Y.1    Dieter, M.Z.2    Chen, Y.3    Shertzer, H.G.4    Nebert, D.W.5    Dalton, T.P.6
  • 53
    • 29244464827 scopus 로고    scopus 로고
    • Altered glutathione redox state in schizophrenia.
    • Yao JK, Leonard S, Reddy R (2006). Altered glutathione redox state in schizophrenia. Dis Markers 22:83-93.
    • (2006) Dis Markers , vol.22 , pp. 83-93
    • Yao, J.K.1    Leonard, S.2    Reddy, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.