Some different effect of PKC inhibitors on the acetylcholine, and endothelin-1-induced contractions of rat bronchial smooth muscle

European Journal of Pharmacology

Volumn 618, Issue 1-3, 2009, Pages 58-62

  Sakai, Hiroyasu ^a   Yamamoto, Maki ^a   Chiba, Yoshihiko ^a   Misawa, Miwa ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Airway smooth muscle; Endothelin 1; PKC isoform

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ACETYLCHOLINE; CALPHOSTIN C; ENDOTHELIN 1; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C IOTA; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C ZETA; ROTTLERIN;

ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; IMMUNOBLOTTING; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE CONTRACTION;

ACETYLCHOLINE; ANIMALS; BRONCHI; ENDOTHELIN-1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOENZYMES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR;

EID: 68949166052     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.07.002     Document Type: Article

References (28)

1. Bruns R.F., Miller F.D., Merriman R.L., Howbert J.J., Heath W.F., Kobayashi E., Takahashi I., Tamaoki T., and Nakano H. Inhibition of protein kinase C by calphostin C is light-dependent. Biochem. Biophys. Res. Commun. 176 (1991) 288-293
2. Chiba Y., Takeyama H., Sakai H., and Misawa M. Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur. J. Pharmacol. 427 (2001) 77-82
3. Chiba Y., Goto K., Hirahara M., Sakai H., and Misawa M. Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation of RhoA in rats. J. Pharmacol. Sci. 106 (2008) 615-625
4. 2+ sensitization of tracheal smooth muscle. Am. J. Physiol. 275 (1998) L748-755
5. 2+ antagonist-insensitive coronary smooth muscle contraction involves activation of epsilon-protein kinase C-dependent pathway. Am. J. Physiol., Cell Physiol. 285 (2003) C1454-1463
6. Eto M., Ohmori T., Suzuki M., Furuya K., and Morita F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J. Biochem. 118 (1995) 1104-1107
7. Eto M., Senba S., Morita F., and Yazawa M. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle. FEBS Lett. 410 (1997) 356-360
8. Gerthoffer W.T., and Murphy R.A. Myosin phosphorylation and regulation of cross-bridge cycle in tracheal smooth muscle. Am. J. Physiol. 244 (1983) C182-187
9. Gschwendt M., Müller H.J., Kielbassa K., Zang R., Kittstein W., Rincke G., and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199 (1994) 93-98
10. 2+-independent vasocontraction. Am. J. Physiol. 265 (1993) 1319-1324
11. Johannes F.J., Prestle J., Eis S., Oberhagemann P., and Pfizenmaier K. PKCμ is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269 (1994) 6140-6148
12. Kanashiro C.A., and Khalil R.A. Signal transduction by protein kinase C in mammalian cells. Clin. Exp. Pharmacol. Physiol. 25 (1998) 974-985
13. 2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle. J. Physiol. 520 (1999) 139-152
14. Kobayashi E., Nakano H., Morimoto M., and Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159 (1989) 548-553
15. Li L., Eto M., Lee M.R., Morita F., Yazawa M., and Kitazawa T. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle. J. Physiol. 508 (1998) 871-881
16. Martiny-Baron G., Kazanietz M.G., Mischak H., Blumberg P.M., Kochs G., Hug H., Marmé D., and Schächtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem. 268 (1993) 9194-9197
17. 2+-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase. J. Gen. Physiol. 104 (1994) 265-286
18. 2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. Hypertension 43 (2004) 897-904
19. 2+ and activators of protein kinase C. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 8835-8839
20. Sakai H., Hirano T., Takeyama H., Chiba Y., and Misawa M. Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: the roles of Rho-kinase and protein kinase C. Can. J. Physiol. Pharm. 83 (2005) 375-381
21. Sakai H., Chiba Y., and Misawa M. Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle. Pulm. Pharmacol. Ther. 20 (2007) 734-739
22. Salamanca D.A., and Khalil R.A. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem. Pharmacol. 25 (2005) 1537-1547
23. Shirasawa Y., Rutland T.J., Young J.L., Dean D.A., and Joseph B.N. Modulation of protein kinase C (PKC)-mediated contraction and the possible role of PKC epsilon in rat mesenteric arteries. Front. Biosci. 8 (2003) a133-138
24. Somlyo A.P., and Somlyo A.V. Signal transduction and regulation in smooth muscle. Nature 372 (1994) 231-236
25. Tamaoki T., and Nakano H. Potent and specific inhibitors of protein kinase C of microbial origin. Biotechnology (N Y) 8 (1990) 732-735
26. Webb B.L., Lindsay M.A., Seybold J., Brand N.J., Yacoub M.H., Haddad E.B., Barnes P.J., Adcock I.M., and Giembycz M.A. Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level. Biochem. Pharmacol. 54 (1997) 199-205
27. 2+ sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J. Physiol. 535 (2001) 553-564
28. Yamakage M. Direct inhibitory mechanisms of halothane on canine tracheal smooth muscle contraction. Anesthesiology 77 (1992) 546-553