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Volumn 106, Issue 4, 2008, Pages 615-625

Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation of RhoA in rats

Author keywords

Airway hyperresponsiveness; Beclomethasone; Bronchial smooth muscle; Prednisolone; RhoA

Indexed keywords

2,4 DINITROPHENOL; ACETYLCHOLINE; ASCARIS ANTIGEN; BECLOMETASONE; GLUCOCORTICOID; MYOSIN LIGHT CHAIN; PREDNISOLONE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 42349098821     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0071825     Document Type: Article
Times cited : (19)

References (60)
  • 2
    • 0001773833 scopus 로고
    • Microscopic structure of airway secretory cells: Variation in hypersecretory disease and effects of drugs
    • Takishima T, Shimura S, editors, New York, NY: Marcel Dekker;
    • Jeffery PK. Microscopic structure of airway secretory cells: variation in hypersecretory disease and effects of drugs. In: Takishima T, Shimura S, editors. Airway secretion: physiological basis for the control of mucus hypersecretion. New York, NY: Marcel Dekker; 1993. p. 149-215.
    • (1993) Airway secretion: Physiological basis for the control of mucus hypersecretion , pp. 149-215
    • Jeffery, P.K.1
  • 4
    • 0031761532 scopus 로고    scopus 로고
    • Structural and functional changes in the airway smooth muscle of asthmatic subjects
    • Seow CY, Schellenberg RR, Pare PD. Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am J Respir Crit Care Med. 1998;158:S179-S186.
    • (1998) Am J Respir Crit Care Med , vol.158
    • Seow, C.Y.1    Schellenberg, R.R.2    Pare, P.D.3
  • 5
    • 0033869307 scopus 로고    scopus 로고
    • The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease
    • Martin JG, Duguet A, Eidelman DH. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur Respir J. 2000;16:349-354.
    • (2000) Eur Respir J , vol.16 , pp. 349-354
    • Martin, J.G.1    Duguet, A.2    Eidelman, D.H.3
  • 8
    • 0033867333 scopus 로고    scopus 로고
    • Relationship between force and regulatory myosin light chain phosphorylation in airway smooth muscle
    • Kai T, Yoshimura H, Jones KA, Warner DO. Relationship between force and regulatory myosin light chain phosphorylation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2000;279:L52-L58.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Kai, T.1    Yoshimura, H.2    Jones, K.A.3    Warner, D.O.4
  • 10
    • 22344440518 scopus 로고    scopus 로고
    • 2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice. Respir Res. 2005;6:Art. No. 4.
    • 2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice. Respir Res. 2005;6:Art. No. 4.
  • 11
    • 22344455236 scopus 로고    scopus 로고
    • Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats
    • Sakai H, Chiba Y, Hirano T, Misawa M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Mol Pharmacol. 2005;68:145-151.
    • (2005) Mol Pharmacol , vol.68 , pp. 145-151
    • Sakai, H.1    Chiba, Y.2    Hirano, T.3    Misawa, M.4
  • 12
    • 28644439933 scopus 로고    scopus 로고
    • Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats
    • Chiba Y, Murata M, Ushikubo H, Yoshikawa Y, Saitoh A, Sakai H, et al. Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats. Am J Respir Cell Mol Biol. 2005;33:574-581.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 574-581
    • Chiba, Y.1    Murata, M.2    Ushikubo, H.3    Yoshikawa, Y.4    Saitoh, A.5    Sakai, H.6
  • 13
    • 0027969286 scopus 로고
    • 2+-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells
    • 2+-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells. J Clin Invest. 1994;94:1397-1403.
    • (1994) J Clin Invest , vol.94 , pp. 1397-1403
    • Satoh, S.1    Kreutz, R.2    Wilm, C.3    Ganten, D.4    Pfitzer, G.5
  • 14
    • 0032877847 scopus 로고    scopus 로고
    • Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
    • Shimokawa H, Seto M, Katsumata N, Amano M, Kozai T, Yamawaki T, et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res. 1999;43:1029-1039.
    • (1999) Cardiovasc Res , vol.43 , pp. 1029-1039
    • Shimokawa, H.1    Seto, M.2    Katsumata, N.3    Amano, M.4    Kozai, T.5    Yamawaki, T.6
  • 15
    • 0034696624 scopus 로고    scopus 로고
    • Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta
    • Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, et al. Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation. 2000;101:1319-1323.
    • (2000) Circulation , vol.101 , pp. 1319-1323
    • Kandabashi, T.1    Shimokawa, H.2    Miyata, K.3    Kunihiro, I.4    Kawano, Y.5    Fukata, Y.6
  • 16
    • 0033879562 scopus 로고    scopus 로고
    • Involvement of Rhokinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
    • Sato M, Tani E, Fujikawa H, Kaibuchi K. Involvement of Rhokinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res. 2000;87:195-200.
    • (2000) Circ Res , vol.87 , pp. 195-200
    • Sato, M.1    Tani, E.2    Fujikawa, H.3    Kaibuchi, K.4
  • 17
    • 0035957574 scopus 로고    scopus 로고
    • Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: Comparison with protein kinase C
    • Chrissobolis S, Sobey CG. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C. Circ Res. 2001;88:774-779.
    • (2001) Circ Res , vol.88 , pp. 774-779
    • Chrissobolis, S.1    Sobey, C.G.2
  • 18
    • 0035990918 scopus 로고    scopus 로고
    • The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline) sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway
    • Sasaki Y, Suzuki M, Hidaka H. The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline) sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther. 2002;93:225-232.
    • (2002) Pharmacol Ther , vol.93 , pp. 225-232
    • Sasaki, Y.1    Suzuki, M.2    Hidaka, H.3
  • 19
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3    Ono, T.4    Kawahara, T.5    Morishita, T.6
  • 20
    • 0035316139 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension
    • Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J. 2001;15:1062-1064.
    • (2001) FASEB J , vol.15 , pp. 1062-1064
    • Mukai, Y.1    Shimokawa, H.2    Matoba, T.3    Kandabashi, T.4    Satoh, S.5    Hiroki, J.6
  • 21
    • 0037423816 scopus 로고    scopus 로고
    • Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
    • Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res. 2003;92:411-418.
    • (2003) Circ Res , vol.92 , pp. 411-418
    • Seko, T.1    Ito, M.2    Kureishi, Y.3    Okamoto, R.4    Moriki, N.5    Onishi, K.6
  • 22
    • 0029759168 scopus 로고    scopus 로고
    • Mechanisms of action of glucocorticoids in asthma
    • Barnes PJ. Mechanisms of action of glucocorticoids in asthma. Am J Respir Crit Care Med. 1996;154:S21-S27.
    • (1996) Am J Respir Crit Care Med , vol.154
    • Barnes, P.J.1
  • 23
    • 0031790599 scopus 로고    scopus 로고
    • Airway smooth muscle as a target of glucocorticoid action in the treatment of asthma
    • Hirst SJ, Lee TH. Airway smooth muscle as a target of glucocorticoid action in the treatment of asthma. Am J Respir Crit Care Med. 1998;158:201S-206S.
    • (1998) Am J Respir Crit Care Med , vol.158
    • Hirst, S.J.1    Lee, T.H.2
  • 24
    • 26944464640 scopus 로고    scopus 로고
    • Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease
    • Panettieri RA Jr. Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1:231-234.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 231-234
    • Panettieri Jr., R.A.1
  • 26
    • 0021281759 scopus 로고
    • Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen. Reversal by corticosteroids
    • Sotomayor H, Badier M, Vervloet D, Orehek J. Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen. Reversal by corticosteroids. Am Rev Respir Dis. 1984;130:56-58.
    • (1984) Am Rev Respir Dis , vol.130 , pp. 56-58
    • Sotomayor, H.1    Badier, M.2    Vervloet, D.3    Orehek, J.4
  • 28
    • 0038675090 scopus 로고    scopus 로고
    • Effects of fluticasone vs. fluticasone/salmeterol on airway calibre and airway hyperresponsiveness in mild persistent asthma
    • Currie GP, Stenback S, Lipworth BJ. Effects of fluticasone vs. fluticasone/salmeterol on airway calibre and airway hyperresponsiveness in mild persistent asthma. Br J Clin Pharmacol. 2003;56:11-17.
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 11-17
    • Currie, G.P.1    Stenback, S.2    Lipworth, B.J.3
  • 29
    • 33745087143 scopus 로고    scopus 로고
    • Potential mechanisms of improvement of airway hyperresponsiveness by inhaled corticosteroid therapy in asthmatic patients
    • Nomura S, Kanazawa H, Asai K, Nomura N, Hirata K, Yoshikawa J. Potential mechanisms of improvement of airway hyperresponsiveness by inhaled corticosteroid therapy in asthmatic patients. J Asthma. 2006;43:113-117.
    • (2006) J Asthma , vol.43 , pp. 113-117
    • Nomura, S.1    Kanazawa, H.2    Asai, K.3    Nomura, N.4    Hirata, K.5    Yoshikawa, J.6
  • 30
    • 22344454473 scopus 로고    scopus 로고
    • Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats
    • Chiba Y, Sakai H, Yu Y, Misawa M. Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats. J Biochem. 2005;137:751-756.
    • (2005) J Biochem , vol.137 , pp. 751-756
    • Chiba, Y.1    Sakai, H.2    Yu, Y.3    Misawa, M.4
  • 31
    • 0028987597 scopus 로고
    • 2+ availability involved in antigen-induced airway hyperresponsiveness in rats
    • 2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur J Pharmacol. 1995;278:79-82.
    • (1995) Eur J Pharmacol , vol.278 , pp. 79-82
    • Chiba, Y.1    Misawa, M.2
  • 33
    • 33644784718 scopus 로고    scopus 로고
    • Corticosteroids: The drugs to beat
    • Barnes PJ. Corticosteroids: the drugs to beat. Eur J Pharmacol. 2006;533:2-14.
    • (2006) Eur J Pharmacol , vol.533 , pp. 2-14
    • Barnes, P.J.1
  • 35
    • 0035004903 scopus 로고    scopus 로고
    • Inhaled corticosteroids: Impact on asthma morbidity and mortality
    • Suissa S, Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J Allergy Clin Immunol. 2001;107:937-944.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 937-944
    • Suissa, S.1    Ernst, P.2
  • 36
  • 40
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999;17:255-281.
    • (1999) Annu Rev Immunol , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 41
    • 17444454662 scopus 로고    scopus 로고
    • Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
    • Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, et al. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med. 1997;185:2143-2156.
    • (1997) J Exp Med , vol.185 , pp. 2143-2156
    • Lee, J.J.1    McGarry, M.P.2    Farmer, S.C.3    Denzler, K.L.4    Larson, K.A.5    Carrigan, P.E.6
  • 42
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.J.5    Walls, C.M.6
  • 45
    • 0034526928 scopus 로고    scopus 로고
    • The effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma
    • Gauvreau GM, Wood LJ, Sehmi R, Watson RM, Dorman SC, Schleimer RP, et al. The effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med. 2000;162:2139-2144.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2139-2144
    • Gauvreau, G.M.1    Wood, L.J.2    Sehmi, R.3    Watson, R.M.4    Dorman, S.C.5    Schleimer, R.P.6
  • 46
    • 0030068235 scopus 로고    scopus 로고
    • Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
    • Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996;183:109-117.
    • (1996) J Exp Med , vol.183 , pp. 109-117
    • Corry, D.B.1    Folkesson, H.G.2    Warnock, M.L.3    Erle, D.J.4    Matthay, M.A.5    Wiener-Kronish, J.P.6
  • 47
    • 0038404953 scopus 로고    scopus 로고
    • Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: Role of eosinophils, IL-5, eotaxin, and IL-13
    • Eum SY, Maghni K, Hamid Q, Eidelman DH, Campbell H, Isogai S, et al. Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13. J Allergy Clin Immunol. 2003;111:1049-1061.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1049-1061
    • Eum, S.Y.1    Maghni, K.2    Hamid, Q.3    Eidelman, D.H.4    Campbell, H.5    Isogai, S.6
  • 48
    • 0027399007 scopus 로고
    • Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats
    • Misawa M, Chiba Y. Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats. Jpn J Pharmacol. 1993;61:41-50.
    • (1993) Jpn J Pharmacol , vol.61 , pp. 41-50
    • Misawa, M.1    Chiba, Y.2
  • 49
    • 0027224085 scopus 로고
    • Strain differences in change in airway responsiveness after repeated antigenic challenge in three strains of rats
    • Chiba Y, Misawa M. Strain differences in change in airway responsiveness after repeated antigenic challenge in three strains of rats. Gen Pharmacol. 1993;24:1265-1272.
    • (1993) Gen Pharmacol , vol.24 , pp. 1265-1272
    • Chiba, Y.1    Misawa, M.2
  • 50
    • 33646023979 scopus 로고    scopus 로고
    • Rho-kinase as a drug target for the treatment of airway hyperresponsiveness in asthma
    • Gosens R, Schaafsma D, Nelemans SA, Halayko AJ. Rho-kinase as a drug target for the treatment of airway hyperresponsiveness in asthma. Mini Rev Med Chem. 2006;6:339-348.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 339-348
    • Gosens, R.1    Schaafsma, D.2    Nelemans, S.A.3    Halayko, A.J.4
  • 51
    • 0036516329 scopus 로고    scopus 로고
    • Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways
    • Takizawa T, Kawada N, Tanaka H, Nagai H. Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways. Biol Pharm Bull. 2002;25:318-322.
    • (2002) Biol Pharm Bull , vol.25 , pp. 318-322
    • Takizawa, T.1    Kawada, N.2    Tanaka, H.3    Nagai, H.4
  • 52
    • 0031871552 scopus 로고    scopus 로고
    • Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists
    • Amrani Y, Panettieri RA Jr. Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists. Thorax. 1998;53:713-716.
    • (1998) Thorax , vol.53 , pp. 713-716
    • Amrani, Y.1    Panettieri Jr., R.A.2
  • 54
    • 9344263478 scopus 로고    scopus 로고
    • Involvement of p42/44 MAPK and RhoA protein in augmentation of AChinduced bronchial smooth muscle contraction by TNF-alpha in rats
    • Sakai H, Otogoto S, Chiba Y, Abe K, Misawa M. Involvement of p42/44 MAPK and RhoA protein in augmentation of AChinduced bronchial smooth muscle contraction by TNF-alpha in rats. J Appl Physiol. 2004;97:2154-2159.
    • (2004) J Appl Physiol , vol.97 , pp. 2154-2159
    • Sakai, H.1    Otogoto, S.2    Chiba, Y.3    Abe, K.4    Misawa, M.5
  • 55
    • 0034530199 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smoothmuscle cells. Modulation by cyclic adenosine monophosphate
    • Ammit AJ, Hoffman RK, Amrani Y, Lazaar AL, Hay DW, Torphy TJ, et al. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smoothmuscle cells. Modulation by cyclic adenosine monophosphate. Am J Respir Cell Mol Biol. 2000;23:794-802.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 794-802
    • Ammit, A.J.1    Hoffman, R.K.2    Amrani, Y.3    Lazaar, A.L.4    Hay, D.W.5    Torphy, T.J.6
  • 57
    • 24944585495 scopus 로고    scopus 로고
    • Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1
    • Desmet C, Gosset P, Henry E, Garze V, Faisca P, Vos N, et al. Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1. Am J Respir Crit Care Med. 2005;172:671-678.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 671-678
    • Desmet, C.1    Gosset, P.2    Henry, E.3    Garze, V.4    Faisca, P.5    Vos, N.6
  • 58
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • Ray A, Prefontaine KE. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci U S A. 1994;91:752-756.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 59
    • 0025130179 scopus 로고
    • Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
    • Schule R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 1990;62:1217-1226.
    • (1990) Cell , vol.62 , pp. 1217-1226
    • Schule, R.1    Rangarajan, P.2    Kliewer, S.3    Ransone, L.J.4    Bolado, J.5    Yang, N.6
  • 60
    • 31944440761 scopus 로고    scopus 로고
    • Corticosteroid effects on cell signalling
    • Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J. 2006;27:413-426.
    • (2006) Eur Respir J , vol.27 , pp. 413-426
    • Barnes, P.J.1


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