Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous β1,4-galactosylated N-glycan profile

Journal of Biological Chemistry

Volumn 284, Issue 31, 2009, Pages 20479-20485

  Strasser, Richard ^a   Castilho, Alexandra ^a   Stadlmann, Johannes ^a   Kunert, Renate ^b   Quendler, Heribert ^c,d   Gattinger, Pia ^a   Jez, Jakub ^a   Rademacher, Thomas ^e   Altmann, Friedrich ^a   Mach, Lukas ^a   Steinkellner, Herta ^a,f  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

^c POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH   (Austria)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e RWTH AACHEN UNIVERSITY   (Germany)

^f NONE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

A PLANTS; ANTI-HIV; BIOLOGICAL POTENCY; CHINESE HAMSTER OVARY CELLS; EFFICIENT PRODUCTION; GALACTOSYLTRANSFERASE; GLOBAL HEALTH; GLYCOFORMS; HUMAN IMMUNODEFICIENCY VIRUS; IN-PLANTS; IN-VIVO; MAMMALIAN CELLS; MONOCLONAL ANTIBODIES (MABS); N-GLYCAN; N-GLYCAN STRUCTURES; N-GLYCANS; N-GLYCOSYLATION; PRODUCTION COST; PROTEIN PROCESSINGS; THERAPEUTIC USE; TOBACCO PLANTS; VIRUS NEUTRALIZATION;

GLYCOSYLATION; MAMMALS; MONOCLONAL ANTIBODIES;

ESTERIFICATION;

BETA 1,4 GALACTOSYLTRANSFERASE; GALACTOSYLTRANSFERASE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS MONOCLONAL ANTIBODY 2G12; HUMAN IMMUNODEFICIENCY VIRUS MONOCLONAL ANTIBODY 4E10; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BIOENGINEERING; CONTROLLED STUDY; DRUG STRUCTURE; HAMSTER; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; STRUCTURE ANALYSIS; TOBACCO; VIRUS NEUTRALIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CROSSES, GENETIC; GALACTOSE; GENETIC VECTORS; GLYCOSYLATION; HIV ANTIBODIES; HIV-1; HUMANS; MUTATION; NEUTRALIZATION TESTS; PLANTIBODIES; POLYSACCHARIDES; PROTEIN ISOFORMS; RATS; TOBACCO; TRANSFORMATION, GENETIC;

CRICETULUS GRISEUS; HUMAN IMMUNODEFICIENCY VIRUS; MAMMALIA; NICOTIANA OBTUSIFOLIA;

EID: 68949137116     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014126     Document Type: Article

References (33)

1. Schweizer, A., Rusert, P., Berlinger, L, Ruprecht, C. R., Mann, A., Corthesy, S., Turville, S. G., Aravantinou, M., Fischer, M., Robbiani, M., Amstutz, P., and-Trkola, A. (2008) PLoS Pathqg. 4, e1000109.
2. Trkola, A., Kuster, H., Rusert, P., Joos, B., Fischer, M., Leemann, C., Manrique, A., Huber, M., Rehr, M., Oxenius, A., Weber, R., Stiegler, G., Vcelar, B., Katinger, H., Aceto, L., and Günthard, H. F. (2005) Nat Med. 11, 615-622
3. Huber, M., Olson, W. C., and Trkola, A. (2008) Curr. Top. Microbiol. Immunol. 317, 39-66
4. Cardoso, R. M., Zwick, M. B., Stanfield, R. L., Kunert, R., Binley, J. M., Katinger, H., Burton, D. R., and Wilson, I. A. (2005) Immunity 22, 163-173
5. Sanders, R. W., Venturi, M., Schiffner, L., Kalyanaraman, R., Katinger, H., Lloyd, K. O., Kwong, P. D., and Moore, J. P. (2002) J. Virol. 76, 7293-7305
6. Raju, T. S. (2008) Curr. Opin. Immunol. 20, 471-488.
7. Marillonnet, S., Thgeringer, C., Kandzia, R., Klimyuk, V., and Gleba, Y. (2005) Nat Biotechnol. 23, 718-723.
8. Sainsbury, F., and Lomonossoff, G. P. (2008) Plant Physiol. 148, 1212-1248
9. Strasser, R., Stadlmann, J., Schähs, Stiegler, G., Quendler, H., Mach, L., Glössl, J., Weterings, K., Pabst, M., and Steinkellner, H. (2008) Plant Biotechnol. J. 6, 392-402
10. Cox, K. M., Sterling, J. D., Regan, J. T., Gasdaska, J.R., Frantz, K. K., Peele, C. G., Black, A., Passmore, D., Moldovan-Loomis, C., Srinivasan, M., Cuison, S., Cardarelli, P. M., and Dickey, L. F. (2006) Nat. Biotechnol. 24, 1591-1597
11. Berger, E. G., Berger, B., Höchli, M., and Dinter, A. (2001) Histochem. Cell Biol. 115, 157-168
12. Strasser, R., Stadlmann, J., Svoboda, B., Altmann, F., Glössl, J., and Mach, L. (2005) Biochem. J. 387, 385-391
13. Wee, E. G., Sherrier, D. J., Prime, T. A., and Dupree, P. (1998) Plant Cell 10, 1759-1768
14. Schähs, M., Strasser, R., Stadlmann, J., Kunert, R., Rademacher, T., and Steinkellner, H. (2007) Plant Biotechnol. J. 5, 657-663
15. Bakker, H., Bardor, M., Molthoff, J. W., Gomord, V., Elbers, I., Stevens, L. H., Jordi, W., Lommen, A., Faye, L., Lerouge, P., Bosch, D., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 2899-2904
16. Li, M., Gao, F., Mascola, J. R., Stamatatos, L., Polonis, V. R., Koutsoukos, M., Voss, G., Goepfert, P., Gilbert, P., Greene, K. M., Bilska, M., Kothe, D. L., Salazar-Gonzalez, J. F., Wei, X., Decker, J. M., Hahn, B. H., and Montefiori, D. C. (2005) J. Virol. 79, 10108-10125
17. Stadlmannn, J., Pabst M., Kolarich, D., Kunert, R., and Altmann, F. (2008) Proteomics 8, 2858-2871
18. Palacpac, N. Q., Yoshida, S., Sakai, H., Kimura, Y., Fujiyama, K., Yoshida, T., and Seki, T. (1999) Proc. Natl. Acad. Sci. USA. 96, 4692-4697
19. Bakker, H., Rouwendal, G. J., Karnoup, A. S., Florack, D. E., Stoopen, G.M., Helsper, J. P., van Ree, R., van Die, I., and Bosch, D. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 7577-7582.
20. Fujiyama, K., Furukawa, A., Katsura, A., Misaki, R., Omasa, T., and Seki, T. (2007) Biochem. Biophys. Res. Commun. 358, 85-91
21. Boevink, P., Oparka, K., Santa Cruz, S., Martin, B., Betteridge, A., and Hawes, C. (1998) Plant J. 15, 441-447
22. Mascola, J. R., D'Souza, P., Gilbert, P., Hahn, B. H., Haigwood, N. L., Morris, L., Petropoulos, C. J., Polonis, V. R., Sarzotti, M., and Montefiori, D. C. (2005) J. Virol. 79, 10103-10107
23. Léonard, R., Costa, G., Darrambide, E., Lhernould, S., Fleurat-Lessard, P., Carlué, M., Gomord, V., Faye, L., and Maftah, A. (2002) Glycobiology 12, 299-306
24. Strasser, R., Bondili, J. S., Vavra, U., Schoberer, J., Svoboda, B., Glössl, J., Léonard, R., Stadlmann, J., Altmann, F., Steinkellner, H., and Mach, L. (2007) Plant Cell 19, 2278-2292
25. Umaña, P., Jean-Mairet, J., Moudry, R., Amstutz, H., and Bailey, J. E. (1999) Nat. Biotechnol. 17, 176-180
26. Yamane-Ohnuki, N., Kiposhita, S., Inoue-Urakubo, M., Kusunoki, M., Iida, S., Nakano, R., Wakitani, M., Niwa, R., Sakurada, M., Uchida, K., Shitara, K., and Satoh, M. (2004) Biotechnol. Bioeng. 87, 614-622
27. Krapp, S., Mimura, Y., Jefferis, R., Huber, R., and Sondermann, P. (2003) J. Mol. Biol. 325, 979-989
28. Scallon, B. J., Tam, S. H., McCarthy, S. G., Cai, A. N., and Raju, T. S. (2007) Mol. Immunol. 44, 1524-1534
29. Giritch, A., Marillonnet, S., Engler, C., van Eldik G., Botterman, J., Klimyuk, V., and Gleba, Y. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 14701-14706
30. Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E., Beurskens, F. J., Bakker, J. M., Lanigan, C. M., Landucci, G., Forthal, D. N., Parren, P. W., Marx, P. A., and Burton, D. R. (2007) Nature 449, 101-104
31. Klasse, P. J., Shattock, R., and Moore, J. P. (2008) Annu. Rev. Med. 59, 455-471
32. Schweizer, A., Rusert, P., Berlinger, L., Ruprecht, C. R., Mann, A., Corthésy, S., Turville, S. G., Aravantinou, M., Fischer, M., Robbiani, M., Amstutz, P., and Trkola, A. (2008) PLoS Pathog. 4, e1000109
33. Reed, L. J., and Muench, H. (1938) Am. J. Hyg. 27, 493-497