Amitriptyline inhibits the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 5, 2009, Pages 577-581

  Baik, Hee Jung ^a,b   Lee, Soon Ae ^a,c   Washington, Jacqueline M ^a   Zuo, Zhi Yi ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b Ewha Womans University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

Amitriptyline; Glutamate; Glutamate transporters; Protein kinase C

Indexed keywords

AMITRIPTYLINE; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ACTIVATOR; ENZYME ACTIVATOR; PROTEIN KINASE C; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG EFFECT; ELECTROPHYSIOLOGY; IC 50; MAJOR DEPRESSION; MICHAELIS CONSTANT; NEUROTRANSMISSION; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; RAT; XENOPUS; ANIMAL; DRUG ANTAGONISM; FEMALE; METABOLISM; PATCH CLAMP; PHYSIOLOGY; XENOPUS LAEVIS;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATORS; EXCITATORY AMINO ACID TRANSPORTER 3; FEMALE; GLUTAMIC ACID; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; RATS; TETRADECANOYLPHORBOL ACETATE; XENOPUS LAEVIS;

EID: 68949125383     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.05.0005     Document Type: Article

References (30)

1. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984; 42: 1-11.
2. Kanai Y, Hediger MA. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 1992; 360: 467-471.
3. Kanai Y et al. A new family of neurotransmitter transporters: the high-affinity glutamate transporters. Faseb J 1993; 7: 1450-1459.
4. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001; 65: 1-105.
5. Rothstein JD et al. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis [see comments]. N Engl J Med 1992; 326: 1464-1468.
6. Torp R et al. Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus: an in situ hybridization analysis. Anat Embryol (Berl) 1997; 195: 317-326.
7. Billups B et al. Physiological and pathological operation of glutamate transporters. Prog Brain Res 1998; 116: 45-57.
8. Cai Z, McCaslin PP. Amitriptyline, desipramine, cyproheptadine and carbamazepine, in concentrations used therapeutically, reduce kainate- and N-methyl-D-aspartate-induced intracellular Ca2+ levels in neuronal culture. Eur J Pharmacol 1992; 219: 53-57.
9. Duman RS et al. Neural plasticity to stress and antidepressant treatment. Biol Psychiatry 1999; 46: 1181-1191.
10. Auer DP et al. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 2000; 47: 305-313.
11. Palucha A, Pilc A. The involvement of glutamate in the pathophysiology of depression. Drug News Perspect 2005; 18: 262-268.
12. Pittenger C et al. The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neurol Disord Drug Targets 2007; 6: 101-115.
13. Eisenach JC, Gebhart GF. Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. Anesthesiology 1995; 83: 1046-1054.
14. McQuay HJ et al. A systematic review of antidepressants in neuropathic pain. Pain 1996; 68: 217-227.
15. Abdel-Salam OM et al. Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res 2003; 48: 157-165.
16. Golembiowska K, Dziubina A. Involvement of adenosine in the effect of antidepressants on glutamate and aspartate release in the rat prefrontal cortex. Naunyn Schmiedebergs Arch Pharmacol 2001; 363: 663-670.
17. Andin J et al. Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline. Brain Res Mol Brain Res 2004; 126: 74-77.
18. Do SH et al. Effects of volatile anesthetics on glutamate transporter, excitatory amino acid transporter type 3. Anesthesiology 2002; 96: 1492-1497.
19. Kim JH et al. Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase. Alcohol Clin Exp Res 2003; 27: 1548-1553.
20. Paul IA, Skolnick P. Glutamate and depression: clinical and preclinical studies. Ann N Y Acad Sci 2003; 1003: 250-272.
21. Tai YH et al. Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats. Pain 2007; 129: 343-354.
22. Baldessarini RJ. Drugs and the treatment of psychiatric disorders: depression and mania. In: Hardman JG et al. eds. Pharmacological Basis of Therapeutics. New York: McGraw Hill, 1996: 431-459.
23. Engelhart DA, Jenkins AJ. Comparison of drug concentrations in postmortem cerebrospinal fluid and blood specimens. J Anal Toxicol 2007; 31: 581-587.
24. Glotzbach RK, Preskorn SH. Brain concentrations of tricyclic antidepressants: single-dose kinetics and relationship to plasma concentrations in chronically dosed rats. Psychopharmacology (Berl) 1982; 78: 25-27.
25. Hasuo H et al. Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus. J Neurosci 2002; 22: 7509-7517.
26. Rothstein JD et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996; 16: 675-686.
27. McCaslin PP et al. Amitriptyline prevents N-methyl-Daspartate (NMDA)-induced toxicity, does not prevent NMDAinduced elevations of extracellular glutamate, but augments kainate-induced elevations of glutamate. J Neurochem 1992; 59: 401-405.
28. Huang Y, Zuo Z. Isoflurane induces a protein kinase C alphadependent increase in cell surface protein level and activity of glutamate transporter type 3. Mol Pharmacol 2005; 67: 1522-1533.
29. Huang Y et al. Critical role of serine 465 in isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3. J Biol Chem 2006; 281: 38133-38138.
30. Dick IE et al. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain 2007; 8: 315-324.