Synthesis of gibberellin derivatives with anti-tumor bioactivities

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5496-5499

  Chen, Jingbo ^a   Sun, Zhuxian ^a   Zhang, Yanli ^b   Zeng, Xianghui ^a   Qing, Chen ^b   Liu, Jianping ^a   Li, Liang ^a   Zhang, Hongbin ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

, Unsaturated ketone; Cytotoxic activities; Diterpenes; Gibberellins

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; GIBBERELLIC ACID; GIBBERELLIN DERIVATIVE; KETONE; ORIDONIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; GIBBERELLINS; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 68949086525     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.090     Document Type: Article

References (22)

1. Hanson J.R. Nat. Prod. Rep. 24 (2007) 1332
2. Hanson J.R. Nat. Prod. Rep. 23 (2006) 875
3. Keyzers R.A., Northcote P.T., and Davies-Coleman M.T. Nat. Prod. Rep. 23 (2006) 321 and references cited therein
4. MacMillan J. Nat. Prod. Rep. 14 (1997) 221
5. Sun H.D., Huang S.X., and Han Q.B. Nat. Prod. Rep. 23 (2006) 673
6. Mander L.N. Chem. Rev. 92 (1992) 573
7. Wang L., Zhao W.-L., Yan J.-S., Liu P., Sun H.-P., Zhou G.-B., Weng Z.-Y., Wu W.-L., Weng X.-Q., Sun X.-J., Chen J., Sun H.-D., and Chen S.-J. Cell Death Differ. 14 (2007) 306
8. Zhao Y., Niu X.-M., Qian L.-P., Liu Z.-Y., Zhao Q.-S., and Sun H.-D. Euro. J. Med. Chem. 42 (2007) 494
9. Leung C.H., Grill S.P., Lam W., Gao W., Sun H.D., and Cheng Y.C. Mol. Pharmacol 70 (2006) 1946
10. Leung C.H., Grill S.P., Lam W., Han Q.B., Sun H.D., and Cheng Y.C. Mol. Pharmacol. 68 (2005) 286
11. Konaklieva M.I., and Plotkin B.J. Med. Chem. 5 (2005) 73
12. Umino K., Furama T., Matzuzawa N., Awataguchi Y., Ito Y., and Okuda T. J. Antibiot. 26 (1973) 506
13. Umino K., Takeda N., Ito Y., and Okuda T. Chem. Pharm. Bull. 22 (1974) 1233
14. Mander L.N. Nat. Prod. Rep. 20 (2003) 49
15. MacMillan J., and Willis C.L. J. Chem. Soc., Perkin Trans. 1 (1986) 309
16. Bhaskar K.V., and Mander L.N. Tetrahedron Lett. 37 (1996) 719
17. Dolan S.C., and MacMillan J. J. Chem. Soc., Perkin Trans. 1 (1985) 2741
18. +: 471.1419. Found: 471.1408.
19. Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., and Boyd M.R. Cancer Res. 48 (1988) 589
20. Zhou J.J., Yue X.F., Han J.X., and Yang W.Y. Chin. J. Pharm. 24 (1993) 455
21. Redinbo M.R., Stewart P., Kuhn P., Champoux J.J., and Hol W.G.J. Science 279 (1998) 1504
22. Redinbo M.R., Champoux J.J., and Hol W.G. Biochemistry 39 (2000) 6832