Obesity and Asthma

Clinics in Chest Medicine

Volumn 30, Issue 3, 2009, Pages 479-488

  Beuther, David A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Adipokines; Asthma; Inflammation; Obesity; Overweight; Pulmonary function testing

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; LEUKOTRIENE RECEPTOR STIMULATING AGENT;

ASTHMA; BODY MASS; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG RESPONSE; HIGH RISK POPULATION; HUMAN; INSULIN RESISTANCE; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUALITY OF LIFE; RESPIRATORY TRACT INFLAMMATION; REVIEW; WEIGHT REDUCTION;

ASTHMA; BODY MASS INDEX; HUMANS; OBESITY; PULMONARY VENTILATION; RISK FACTORS;

EID: 68849128511     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2009.05.002     Document Type: Review

References (83)

1. Ford E.S. The epidemiology of obesity and asthma. J Allergy Clin Immunol 115 5 (2005) 897-909 quiz 910
2. Guerra S., Sherrill D.L., Bobadilla A., et al. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest 122 4 (2002) 1256-1263
3. Shaheen S.O., Sterne J.A., Montgomery S.M., et al. Birth weight, body mass index and asthma in young adults. Thorax 54 5 (1999) 396-402
4. Beckett W.S., Jacobs Jr. D.R., Yu X., et al. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J Respir Crit Care Med 164 11 (2001) 2045-2050
5. Litonjua A.A., Sparrow D., Celedon J.C., et al. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax 57 7 (2002) 581-585
6. Huovinen E., Kaprio J., and Koskenvuo M. Factors associated to lifestyle and risk of adult onset asthma. Respir Med 97 3 (2003) 273-280
7. Wyatt S.B., Winters K.P., and Dubbert P.M. Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. Am J Med Sci 331 4 (2006) 166-174
8. Rhodes L., Bailey C.M., and Moorman J.E. Asthma prevalence and control characteristics by race/ethnicity-United States, 2002. Morb Mortal Wkly Rep 53 7 (2004) 145-148
9. Pianosi P.T., and Davis H.S. Determinants of physical fitness in children with asthma. Pediatrics 113 3 Pt 1 (2004) e225-e229
10. Camargo Jr. C.A., Weiss S.T., Zhang S., et al. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 159 21 (1999) 2582-2588
11. Ford E.S., Mannino D.M., Redd S.C., et al. Body mass index and asthma incidence among USA adults. Eur Respir J 24 5 (2004) 740-744
12. Gunnbjornsdottir M.I., Omenaas E., Gislason T., et al. Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 24 1 (2004) 116-121
13. Chen Y., Dales R., Tang M., et al. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 155 3 (2002) 191-197
14. Nystad W., Meyer H.E., Nafstad P., et al. Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol 160 10 (2004) 969-976
15. Beuther D.A., and Sutherland E.R. Overweight, obesity and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 175 7 (2007) 661-666
16. Hu F.B., Willett W.C., Li T., et al. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med 351 26 (2004) 2694-2703
17. Biring M.S., Lewis M.I., Liu J.T., et al. Pulmonary physiologic changes of morbid obesity. Am J Med Sci 318 5 (1999) 293-297
18. Naimark A., and Cherniack R.M. Compliance of the respiratory system and its components in health and obesity. J Appl Physiol 15 (1960) 377-382
19. Babb T.G., Ranasinghe K.G., Comeau L.A., et al. Dyspnea on exertion in obese women: association with an increased oxygen cost of breathing. Am J Respir Crit Care Med 178 2 (2008) 116-123
20. Sin D.D., Jones R.L., and Man S.F. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med 162 13 (2002) 1477-1481
21. Ronmark E., Andersson C., Nystrom L., et al. Obesity increases the risk of incident asthma among adults. Eur Respir J 25 2 (2005) 282-288
22. Aaron S.D., Vandemheen K.L., Boulet L.P., et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ 179 11 (2008) 1121-1131
23. Hallstrand T.S., Fischer M.E., Wurfel M.M., et al. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 116 6 (2005) 1235-1241
24. Hall I.P., Wheatley A., Wilding P., et al. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345 8959 (1995) 1213-1214
25. Ishiyama-Shigemoto S., Yamada K., Yuan X., et al. Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia 42 1 (1999) 98-101
26. Moffatt M.F., James A., Ryan G., et al. Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample. Thorax 54 9 (1999) 757-761
27. Norman R.A., Bogardus C., and Ravussin E. Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 96 1 (1995) 158-162
28. Dempsey J.A., Skatrud J.B., Jacques A.J., et al. Anatomic determinants of sleep-disordered breathing across the spectrum of clinical and nonclinical male subjects. Chest 122 3 (2002) 840-851
29. Guilleminault C., Quera-Salva M.A., Powell N., et al. Nocturnal asthma: snoring, small pharynx and nasal CPAP. Eur Respir J 1 10 (1988) 902-907
30. Martin R.J., and Pak J. Nasal CPAP in nonapneic nocturnal asthma. Chest 100 4 (1991) 1024-1027
31. Havemann B.D., Henderson C.A., and El-Serag H.B. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut 56 12 (2007) 1654-1664
32. Eneli I.U., Skybo T., and Camargo Jr. C.A. Weight loss and asthma: a systematic review. Thorax 63 8 (2008) 671-676
33. Dixon J.B., Chapman L., and O'Brien P. Marked improvement in asthma after Lap-Band surgery for morbid obesity. Obes Surg 9 4 (1999) 385-389
34. Ahroni J.H., Montgomery K.F., and Watkins B.M. Laparoscopic adjustable gastric banding: weight loss, co-morbidities, medication usage and quality of life at one year. Obes Surg 15 5 (2005) 641-647
35. Macgregor A.M., and Greenberg R.A. Effect of surgically induced weight loss on asthma in the morbidly obese. Obes Surg 3 1 (1993) 15-21
36. Stenius-Aarniala B., Poussa T., Kvarnstrom J., et al. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 320 7238 (2000) 827-832
37. Jones R.L., and Nzekwu M.M. The effects of body mass index on lung volumes. Chest 130 3 (2006) 827-833
38. Bedell G.N., Wilson W.R., and Seebohm P.M. Pulmonary function in obese persons. J Clin Invest 37 7 (1958) 1049-1060
39. Thomas P.S., Cowen E.R., Hulands G., et al. Respiratory function in the morbidly obese before and after weight loss. Thorax 44 5 (1989) 382-386
40. Ochs-Balcom H.M., Grant B.J., Muti P., et al. Pulmonary function and abdominal adiposity in the general population. Chest 129 4 (2006) 853-862
41. Collins L.C., Hoberty P.D., Walker J.F., et al. The effect of body fat distribution on pulmonary function tests. Chest 107 5 (1995) 1298-1302
42. Lazarus R., Sparrow D., and Weiss S.T. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest 111 4 (1997) 891-898
43. Rubinstein I., Zamel N., DuBarry L., et al. Airflow limitation in morbidly obese, nonsmoking men. Ann Intern Med 112 11 (1990) 828-832
44. Hedenstierna G., Santesson J., and Norlander O. Airway closure and distribution of inspired gas in the extremely obese, breathing spontaneously and during anaesthesia with intermittent positive pressure ventilation. Acta Anaesthesiol Scand 20 4 (1976) 334-342
45. Fredberg J.J., Inouye D.S., Mijailovich S.M., et al. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 159 3 (1999) 959-967
46. Wang L.Y., Cerny F.J., Kufel T.J., et al. Simulated obesity-related changes in lung volume increases airway responsiveness in lean, nonasthmatic subjects. Chest 130 3 (2006) 834-840
47. Chinn S., Jarvis D., and Burney P. Relation of bronchial responsiveness to body mass index in the ECRHS. European Community Respiratory Health Survey. Thorax 57 12 (2002) 1028-1033
48. Schachter L.M., Salome C.M., Peat J.K., et al. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 56 1 (2001) 4-8
49. Bibi H., Shoseyov D., Feigenbaum D., et al. The relationship between asthma and obesity in children: is it real or a case of over diagnosis?. J Asthma 41 4 (2004) 403-410
50. Aaron S.D., Fergusson D., Dent R., et al. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 125 6 (2004) 2046-2052
51. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115 5 (2005) 911-919
52. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 12 (2003) 1796-1808
53. Wellen K.E., and Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112 12 (2003) 1785-1788
54. Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112 12 (2003) 1821-1830
55. Esposito K., Pontillo A., Di Palo C., et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289 14 (2003) 1799-1804
56. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21 6 (2000) 697-738
57. Thuesen B.H., Husemoen L.L., Hersoug L.G., et al. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy 39 5 (2009) 700-707
58. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 6423 (1993) 801-809
59. Pai J.K., Pischon T., Ma J., et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351 25 (2004) 2599-2610
60. Bruno A., Chanez P., Chiappara G., et al. Does leptin play a cytokine-like role within the airways of COPD patients?. Eur Respir J 26 3 (2005) 398-405
61. Shore S.A., Schwartzman I.N., Mellema M.S., et al. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 115 1 (2005) 103-109
62. Shore S.A., Rivera-Sanchez Y.M., Schwartzman I.N., et al. Responses to ozone are increased in obese mice. J Appl Physiol 95 3 (2003) 938-945
63. Johnston R.A., Theman T.A., Lu F.L., et al. Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol 104 6 (2008) 1727-1735
64. Johnston R.A., Theman T.A., and Shore S.A. Augmented responses to ozone in obese carboxypeptidase E-deficient mice. Am J Physiol Regul Integr Comp Physiol 290 1 (2006) R126-R133
65. Lu F.L., Johnston R.A., Flynt L., et al. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290 5 (2006) L856-L865
66. Shore S.A., Terry R.D., Flynt L., et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118 2 (2006) 389-395
67. Gurkan F., Atamer Y., Ece A., et al. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol 93 3 (2004) 277-280
68. Guler N., Kirerleri E., Ones U., et al. Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol 114 2 (2004) 254-259
69. Sood A., Cui X., Qualls C., et al. Association between asthma and serum adiponectin concentration in women. Thorax 63 10 (2008) 877-882
70. Sood A., Qualls C., Seagrave J., et al. Effect of specific allergen inhalation on serum adiponectin in human asthma. Chest 135 2 (2009) 287-294
71. McLachlan C.R., Poulton R., Car G., et al. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol 119 3 (2007) 634-639
72. van Veen I.H., Ten Brinke A., Sterk P.J., et al. Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy 63 5 (2008) 570-574
73. Sutherland T.J., Cowan J.O., Young S., et al. The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med 178 5 (2008) 469-475
74. Lessard A., Turcotte H., Cormier Y., et al. Obesity and asthma: a specific phenotype?. Chest 134 2 (2008) 317-323
75. Taylor B., Mannino D., Brown C., et al. Body mass index and asthma severity in the National Asthma Survey. Thorax 63 1 (2008) 14-20
76. Rodrigo G.J., and Plaza V. Body mass index and response to emergency department treatment in adults with severe asthma exacerbations: a prospective cohort study. Chest 132 5 (2007) 1513-1519
77. Mosen D.M., Schatz M., Magid D.J., et al. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 122 3 (2008) 507-511 e506
78. Tantisira K.G., Litonjua A.A., Weiss S.T., et al. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 58 12 (2003) 1036-1041
79. Sutherland ER, for the ACRN. Obesity, Asthma Phenotype and Response to Therapy in Asthma Clinical Research Network Trials. Presented at the American Thoracic Society International Conference. San Francisco, California, May 18-23, 2007.
80. Wenzel S.E., and Busse W.W. Severe asthma: lessons from the Severe Asthma Research Program. J Allergy Clin Immunol 119 1 (2007) 14-21 quiz 22-13
81. Peters-Golden M., Swern A., Bird S.S., et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 27 3 (2006) 495-503
82. Boulet L.P., and Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 101 11 (2007) 2240-2247
83. Sutherland E.R., Goleva E., Strand M., et al. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 178 7 (2008) 682-687