Recent trends in oral drug delivery: A review

Recent Patents on Drug Delivery and Formulation

Volumn 3, Issue 2, 2009, Pages 162-173

  Gupta, Himanshu ^a   Bhandari, Dinesh ^b   Sharma, Aarti ^a  

^a HAMDARD UNIVERSITY   (India)

^b D J College of Engineering and Technology   (India)

Author keywords

Colon targeting; Controlled drug delivery; Gastroretentive formulation; Microemulsion; Nanoemulsion; Orally disintegrating tablets; Osmotic pumps; Prodrugs

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; AMOXICILLIN; BALSALAZIDE; CHITOSAN; CREMOPHOR; CYCLOSPORIN; DILTIAZEM; DIPYRIDAMOLE; DRUG; EUDRAGIT; FENOVERINE; FLUOROURACIL; GLIBENCLAMIDE; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; IPSALAZIDE; MACROGOL; METFORMIN; METRONIDAZOLE; MICROSPHERE; NANOPARTICLE; OLANZAPINE; OLSALAZINE; PACLITAXEL; PECTIN; POLYMER; PROPOFOL; SALAZOSULFAPYRIDINE; UNINDEXED DRUG; PHARMACEUTICAL VEHICLES AND ADDITIVES; PRODRUG;

CONTROLLED RELEASE FORMULATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COATING; DRUG COST; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG DOSE REDUCTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RELEASE; DRUG RETENTION; DRUG SOLUBILITY; DRUG STABILITY; DUODENUM ULCER; ENTERIC COATED TABLET; ENTERITIS; FIRST PASS EFFECT; GASTROINTESTINAL ABSORPTION; HEALTH CARE COST; HUMAN; LOW DRUG DOSE; MICROEMULSION; NANOTECHNOLOGY; OSMOSIS; PARTICLE SIZE; PATENT; PATIENT COMPLIANCE; PH; PRIORITY JOURNAL; REVIEW; STOMACH ULCER; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET MANUFACTURE; TABLET PROPERTY; TARGET ORGAN; TREND STUDY; UNSPECIFIED SIDE EFFECT; CHEMISTRY; DELAYED RELEASE FORMULATION; EMULSION; INTESTINE ABSORPTION; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PHYSIOLOGY;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EMULSIONS; HUMANS; INTESTINAL ABSORPTION; PATENTS AS TOPIC; PRODRUGS; TECHNOLOGY, PHARMACEUTICAL;

EID: 68849125081     PISSN: 18722113     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221109788452267     Document Type: Review

References (97)

1. Brahmankar DM, Jaiswal SB. Absorption of drugs. In: Biopharmaceutics and pharmacokinetics a treatise. Delhi, Vallabh Prakashan 2006; 51.
2. http://www.hughes-medical.com/products/fast-dissolving-tablets2.htm
3. Pilgaonkar, P.S., Rustomjee, M.T., Gandhi, A.S., Bagde, P., Morvekar, H.N.: EP2001450 (2008).
4. Dina NM, Madhu B, Shailendra KS, Sengodan GVK. Spray dried excipient base-a novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006; 54: 99-102.
5. http://www.eurand.com/Technologies/Dosage-FormTechnology/AdvaTab/
6. http://www.akinainc.com/frosta.htm
7. http://www.spipharma.com/downloads/Products/DDS/Advantol_2000/ Advantol_Tech_Bulletin.pdf
8. http://books.google.co.in/books?id=mw9W82MLYZ8C&pg=PA215&lpg= PA215&dq=WOWTAB%2Bfirst+patented%2Bhighmoldability+saccharide%2B Yamanouchi+Pharma&source=web&ots=_phBQ_THjL&sig= ftrfOeOE6uD6Bi8B7oPUx58iOds&hl=en&sa=X&oi= book_result&resnum=1&ct=result
9. Ito A, Sugihara M. Development of oral dosage form for elderly patients-use of agar as base of rapidly disintegrating oral tablets. Chem Pharm Bull (Tokyo) 1996; 44:2132-2136.
10. http://www.cimalabs.com/technology/orasolv
11. http://www.cimalabs.com/technology/durasolv
12. Ozeki T, Yasuzawa Y, Katsuyama H, et al. Design of rapidly disintegrating oral tablets using acid treated yeast cell wall: A technical note. AAPS Pharm Sci Tech 2003; 4: 70.
13. Fukami J, Ozawa A, Yoshihashi Y, Yonemochi E, Terada K. Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator. Chem Pharm Bull (Tokyo) 2005; 53:1536-1539.
14. Brown, R.M. Jr.: EP0346507 (1989).
15. Rios M. Polymers for controlled release formulation follows function. Pharmatech Com Pharm Technol 2005; 6: 9.
16. http://www.expresspharmaonline.com/20080731/research03.shtml
17. Chidambaram N, William P, Kolette F, Yihong Q. Formulation and characterization of new layered diffusional matrices for zero-order sustained release. J Control Release 1998; 52:149-158.
18. Ravi K, Shiirwaikar AA, Shirwaikar A, Mahalaxmi R, Parba LS. Formulation and evaluation of mouth dissolving tablets of metformin HCl. Int J Pharm Excipients 2006; 5: 86.
19. http://www.skyepharma.com/technology/oral-technology/geomatrix/
20. Dharmadhikari, N.B., Zala, Y.R.: WO2006123364 (2006).
21. Fukami J, Yonemochi E, Yoshihashi Y, Terada K. Evaluation of rapidly disintegrating tablets containing glycine and carboxy-methylcellulose. Int J Pharm 2006; 310:101-109.
22. Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: Effect of superdisintegrants. Drug Dev Ind Pharm 2007; 33:1225-1232.
23. Mishra DN, Bindal M, Singh SK, Vijaya KSG. Spray dried excipient base: A novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull (Tokyo) 2006; 54: 99-102.
24. Brahmankar DM, Jaiswal SB. Controlled release medication. In Biopharmaceutics and pharmacokinetics a treatise. Delhi, Vallabh Prakashan 2006; 355-356.
25. Jon, S., Farokhazd, O.C., Langer, R.S., Cheng, J.: WO2007001448 (2007).
26. http://www.elan.com/EDT/oral_controlled_release_technology/ipdas
27. Moës AJ. Gastroretentive dosage forms. Crit Rev Ther Drug Carrier Syst 1993; 10:143-195.
28. Choudhury PK, Kar M, Chauhan CS. Cellulose acetate microspheres as floating depot systems to increase gastric retention of antidiabetic drug: Formulation, characterization and in vitro-in vivo evaluation. Drug Dev Ind Pharm 2008; 34:349-354.
29. Majithiya RJ, Murthy RS. Chitosan-based mucoadhesive microspheres of clarithromycin as a delivery system for antibiotic to stomach. Curr Drug Deliv 2005; 2:235-242.
30. Ito, K., Mizobata, K., Kamimura, M., Shobu, T.: WO2008075448 (2008).
31. Patel JK, Patel MM. Stomach specific anti-helicobacter pylori therapy: Preparation and evaluation of amoxicillin-loaded chitosan mucoadhesive microspheres. Curr Drug Deliv 2007; 4: 41-50.
32. Dhaliwal S, Jain S, Singh HP, Tiwary AK. Mucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo Evaluation. AAPS J 2008; 10:322-330.
33. Fischer, G., Bar-Shalom, D., Slot, L., Lademann, A.M., Jensen, C.: US2008234352 (2008).
34. Chatterji, A., Dong, Z., Sandhu, H.K., Shah, N.H.: US2008293787 (2008).
35. Pardeep KG. Solution and phase equilibria; In: Remington the science and practice of pharmacy. New Delhi, Wolters Kluwer India 2007; 211-230.
36. http://www.pedinol.com/GrisPEG/Gris-PEG%20(about%20grispeg).htm
37. Valleri M, Mura P, Maestrelli F, Cirri M, Ballerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique. Drug Dev Ind Pharm 2004; 30: 525-534.
38. Velluto D, Demurtas D, Hubbell JA. PEG-b-PPS Diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin a as an example. Mol Pharm 2008; 5: 632-642.
39. Corswant, C.V.: MX9801755 (1998).
40. Tang Y, Liu SY, Armes SP, Billingham NC. Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers. Biomacromolecules 2003; 4: 1636-1645.
41. Ong, J., Stetsko, G., Levy, O.E., Ghosh, S.S.: WO2005037250 (2005).
42. Chi-Yuan W, Leslie ZB. Predicting drug disposition via application of BCS. Pharm Res 2005; 22:11-23.
43. http://www.skyepharma.com/technology/oral-technology/ particle-engineering-technologies/insoluble-drug-delivery-platform.html
44. Yi T, Wan J, Xu H, Yang X. Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose. Eur J Pharm Sci 2008; 34: 274-280.
45. Serratoni M, Newton M, Booth S, Clarke A. Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system. Eur J Pharm Biopharm 2007; 65: 94-98.
46. Bansal T, Mustafa G, Khan ZI, Ahmad FJ, Khar RK, Talegaonkar S. Solid self-nanoemulsifying delivery systems as a platform technology for formulation of poorly soluble drugs. Crit Rev Ther Drug Carrier Syst 2008; 25:63-116.
47. Odidi, I., Odidi, A.: CA2579382 (2008).
48. Venkatesh, G.M., Qian, K. K., Vangala, S., Clevenger, J.M., Guenther, D.: WO2005105049 (2005).
49. http://www.elan.com/EDT/nanocrystal_technology
50. Yun, S.L.J., Chen, J.F.: US2008212402 (2008).
51. http://www.eurand.com/Technologies/Bioavailability-enhancement/Biorise/
52. Bar-Shalom, D., Fischer, G., Slot, L., Lademann, A.M.: EP1974726 (2008).
53. http://www.flamel.com/techAndProd/medusa.shtml
54. Jabr-Milane L, Van Vlerken L, Devalapally H, et al. Multifunctional nanocarriers for targeted delivery of drugs and genes. J Control Release 2008; 130:121-128.
55. http://labs.tdl.org/tdl/handle/2152/125
56. Svenson, S., Tucker, C.J., Hitt, J.E.: WO2004012710 (2004).
57. Svenson, S., Tucker, C.J., Lubetkin, S.D., Evans, J.C., Rosenberg, S.S.: WO059319 (2003).
58. Williams, R.O. III., Johnston, K.P., Young, T.J., Rogers, T.L., Barron, M.K., Yu, Z., Hu, J.: WO060411 (2002).
59. De Jaeghere F, Allémann E, Cerny R, et al. pH-Dependent dissolving nano and microparticles for improved peroral delivery of a highly lipophilic compound in dogs. AAPS Pharm Sci 2001; 3: 8.
60. Kossena GA, Charman WN, Boyd BJ, Porter CJ. A novel cubic phase of medium chain lipid origin for the delivery of poorly water soluble drugs. J Control Release 2004; 99: 217-229.
61. Breitenkamp, K., Sill, K., Skaff, H., Breintenkamp, R.: WO2006107903 (2006).
62. Molavi O, Ma Z, Mahmud A, et al. Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. Int J Pharm 2008; 347:118-127.
63. Ravenelle F, Vachon P, Rigby-Jones AE, et al. Anaesthetic effects of propofol polymeric micelle: A novel water soluble propofol formulation. Br J Anaesth 2008; 101:186-193.
64. http://www.prnewswire.com/cgi-bin/stories.pl
65. www.cimalab.com
66. http://www.akinainc.com/hytrocell.htm
67. http://www.lipocine.com/content/view/53/506/
68. Shimoni, E., Ramon, O., Kopelman, I.J., Mizrahi, S., Salzman, N., Nahmias, Y., Oren, A.: WO2008132727 (2008).
69. Quan JS, Jiang HL, Kim EM, et al. pH-Sensitive and mucoadhesive thiolated eudragit-coated chitosan microspheres. Int J Pharm 2008; 359:205-210.
70. http://www.emisphere.com/eligen.html
71. Sarasija S, Hota A. Colon-specific drug delivery systems. Indian J Pharm Sci 2000; 62:1-8.
72. Ashford M, Fell JT, Attwood D, Sharma H, Woodhead PJ. An in vivo investigation into the suitability of pH-dependent polymers for colonic targeting. Int J Pharm 1993; 95:193-199.
73. Hita V, Ranjit S, Sanjay KJ. Colonic targeting of metronidazole using azo aromatic polymers: Development and characterization. Drug Deliv 1997; 4:19-22.
74. Zhao XL, Li KX, Zhao XF, Pang DH, Chen DW. Study on colon-specific 5-Fu pH-enzyme di-dependent chitosan microspheres. Chem Pharm Bull (Tokyo) 2008; 56: 963-968.
75. Paharia A, Yadav AK, Rai G, Jain SK, Pancholi SS, Agrawal GP. Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting. AAPS Pharm Sci Tech 2007; 8: 12.
76. Chellan VR, Chithambaram M, Joseph AJLJ, Thengungal KR. An in vitro and in vivo investigation into the suitability of bacterially triggered delivery system for colon targeting. Chem Pharm Bull 2002; 50: 892-895.
77. Ravi V, Pramod KT, Siddaramaiah. Novel colon targeted drug delivery system using natural polymers. Indian J Pharm Sci 2008; 70: 111-113.
78. http://www.imagesrising.com/ypt/ocas.shtml
79. http://www.aapspharmsci.org/abstracts/AM_1999/1686.htm
80. Chourasia MK, Jain SK. Polysaccharides for colon targeted drug delivery. Drug Deliv 2004; 11:129-148.
81. Leong CW, Newton JM, Basit AW, Podczeck F, Cummings JH, Ring SG. The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37°C. Eur J Pharm Biopharm 2002; 54: 291-297.
82. Siew LF, Basit AW, Newton JM. The potential of organic-based amylose-ethylcellulose film coatings as oral colon-specific drug delivery systems. AAPS Pharm Sci Tech 2000; 1: 22.
83. http://www.shvoong.com/medicine-and-health/ 1609118-preparation-5-amino-salicylic-acid/
84. Valluru R, Siddaramaiah, Pramod KT. Influence of natural polymer coating on novel colon targeting drug delivery system. Mater. Sci Mater. Med 2008; 19: 2131-2136.
85. Ling C, Xiaoxi L, Yansheng P, Lin L, Ximei Z, Long Y. Resistant starch as a carrier for oral colon-targeting drug matrix system. J Mater. Sci Mater. Med 2007; 18: 2199-2203.
86. Xing L, Dawei C, Liping X, Rongqing Z. Oral colon-specific drug delivery for bee venom peptide: Development of a coated calcium alginate gel beads-entrapped liposome. J Control Release 2003; 93: 293-300.
87. El-Gibaly I. Oral delayed-release system based on zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int J Pharm 2002; 232: 99-211.
88. Chourasia MK, Jain SK. Potential of guar gum microspheres for target specific drug release to colon. J Drug Target 2004; 12: 435-442.
89. Xuan D, Adam WGA, Joseph RR. Extended-release and targeted drug; In: Remington the science and practice of pharmacy. New Delhi, Wolters Kluwer India 2007; p. 958.
90. El-Kamel AH, Abdel-Aziz AA, Fatani AJ, El-Subbagh HI. Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: Synthesis, in vitro and in vivo assessment. Int J Pharm 2008; 358: 248-255.
91. Pang YN, Zhang ZR, Pang QJ, Li TL. Study on the enzyme dependant colon targeting prodrug-dexamethasone succinate dextran and its tablets. Yao Xue Xue Bao Acta Pharm Sin 2001; 36: 625-630.
92. Jain A, Gupta Y, Jain SK. Azo chemistry and its potential for colonic delivery. Crit Rev Ther Drug Carrier Syst 2006; 23: 349-400.
93. http://www.imagesrising.com/ypt/codes.shtml
94. Prabhu S, Kanthamneni N. A targeted nanotechnology-based therapeutic system for the combined chemoprevention of colon cancer. Nanotech 2007 Conference Program Abstract.
95. Takada, K., Murakami, M.: US20056890547 (2005).
96. Takada, K.: US5637319 (1997).
97. Patel, H.B.: US2007128280 (2007).