Melatonin protects against hydrogen peroxide-induced gastric injury in rats

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 4, 2009, Pages 367-372

  Mohamadin, Ahmed M ^a   Ashour, Osama M ^b   El Sherbeny, Nagla A ^a   Alahdal, Abdulrahman M ^c   Morsy, Gehan M ^b   Abdel Naim, Ashraf B ^b,c  

^a Department of Clinical Biochemistry ^*

^b TAIBAH UNIVERSITY   (Saudi Arabia)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Hydrogen peroxide; Melatonin; Rat stomach

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALONALDEHYDE; MELATONIN; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; STATISTICAL ANALYSIS; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH JUICE; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; HYDROGEN PEROXIDE; MALE; MELATONIN; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 68849122444     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05072.x     Document Type: Article

References (63)

1. Borg DC. Oxygen free radical and tissue injury. In : Tarr M, Samson F (eds). Oxygen Free Radicals and Tissue Injury. Birkhauser, Boston. 1993 12 53.
2. Konturek SJ, Konturek PC, Brzozowska I et al. Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT). J. Physiol. Pharmacol. 2007 58 : 381 405.
3. Henry MC, Wheeler J, Mofenson HC et al. Hydrogen peroxide 3% exposures. J. Toxicol. Clin. Toxicol. 1996 34 : 323 7.
4. Laudanno O, Bedini O, Cesolari J, Miguel P. Evidence of antioxidant role of sucralfate in gastric mucosal protection. Ital. J. Gastroenterol. 1990 22 : 19 21.
5. 2, N-acetylcysteine and proton pump inhibitor BY 831-78 on hydrogen peroxide-induced mucosal damage in the rat stomach. Digestion 1990 46 : 97 106.
6. Lerner AB, Case JD, Lee TH, Mori W. Isolation of melatonin, the pineal factor that lightens melanocytes. J. Am. Chem. Soc. 1958 80 : 2587.
7. Huether G. Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann. N.Y. Acad. Sci. 1994 719 : 146 58.
8. Bubenik GA. Gastrointestinal melatonin: Localization, function and clinical relevance. Dig. Dis. Sci. 2002 10 : 2336 48.
9. Drago F, Macuada S, Salehi S. Small doses of melatonin increase intestinal motility in rats. Dig. Dis. Sci. 2002 47 : 1969 74.
10. Sjoblom M, Flemstrom G. Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion. J. Pineal Res. 2003 34 : 288 93.
11. Barrett P, Conway S, Morgan PJ. Digging deep: Structure-function relationships in the melatonin receptor family. J. Pineal Res. 2003 35 : 221 30.
12. De La Lastra CA, Cabeza J, Motilva V, Martin MJ. Melatonin protects against gastric ischaemia-reperfusion injury in rats. J. Pineal Res. 1997 23 : 47 52. (Pubitemid 127731737)
13. Ianas O, Olivescu R, Badescu I. Melatonin involvement in oxidative processes. Endocrinologie 1991 29 : 147 53.
14. Tan D, Chen L, Poeggeler B, Manchester L, Reiter R. Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J. 1993 1 : 57 60.
15. Matuszak Z, Reszka K, Chignell C. Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations. Free Radic. Biol. Med. 1997 23 : 367 72.
16. Stascia P, Ulanski P, Rosiak J. Reactions of melatonin with radicals in deoxygenated aqueous solution. J. Radioanal. Nucl. Chem. 1998 232 : 107 13.
17. Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress: A review. J. Biomed. Sci. 2000 7 : 444 58.
18. Rodriquez C, Mayo JC, Sainz RJ et al. Regulation of antioxidant enzymes: A significant role for melatonin. J. Pineal Res. 2004 36 : 1 9.
19. Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: Protection by melatonin. Curr. Mol. Med. 2001 1 : 501 13.
20. Cabeza J, Alercon de la Lastra CA, Jimenez D, Martin MJ, Motilva V. Melatonin modulates the effects o gastric injury in rats: Role of prostaglandins and nitric oxide. Neurosignals 2003 12 : 71 7.
21. Bandyopadhyay D, Bandyopadhyay A, Das PK, Reiter RJ. Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J. Pineal Res. 2002 33 : 1 7.
22. Ganguly K, Kundu P, Banerjee A, Reiter RJ, Swarnakar S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radic. Biol. Med. 2006 41 : 911 25.
23. Bandyopadhyay D, Ghosh G, Bandyopadhyay A, Reiter RJ. Melatonin protects against piroxicam-induced gastric ulceration. J. Pineal Res. 2004 36 : 195 203.
24. Sener-Muratoglu G, Paskalogku K, Arbak S, Hurdag C, Ayanoglu-Dulger G. Protective effect of famotidine, omeprazole and melatonin against acetyl salicylic acid-induced gastric damage in rats. Dig. Dis. Sci. 2001 46 : 318 30.
25. Swarnakar S, Mishra A, Ganguly K, Sharma AV. Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice. J. Pineal Res. 2007 43 : 56 64.
26. Reiter RJ, Tan DX, Gitto E et al. Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage. Pol. J. Pharmacol. 2004 56 : 159 70.
27. Reiter RJ, Tan D-X, Mayo JC, Sainz RM, Leon J, Bandyopadhyay D. Neurally-mediated and neutrally-independent beneficial actions of melatonin in the gastrointestinal tract. J. Physiol. Pharmacol. 2003 54 (Suppl. 4 113 25.
28. Yoshikawa T, Yasuda M, Ueda S et al. Vitamin E in gastric mucosal injury induced by ischemia-reperfusion. Am. J. Clin. Nutr. 1991 53 (Suppl S210 14.
29. Aluments J, Klund ME, Hakanson RH. Gastric acid response to pyloric ligation in rats. J. Physiol. 1982 323 : 145 6.
30. Hara N, Hara Y, Natsume Y, Goto Y. Gastric hyperacidity and mucosal damage caused by hypothermia correlate with increase in GABA concentrations of the rat brain. Eur. J. Pharmacol. 1991 194 : 77 81.
31. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 1978 86 : 271 8.
32. Adams J, Lauterburg B, Mitchell J. Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress. J. Pharmacol. Exp. Ther. 1983 227 : 749 54.
33. Paglia DE, Valentine W. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967 70 : 158 69.
34. Virella G. Immunoserology. In : Virella G (ed.). Medical Immunology, 4th edn. Marcel Dekker, New York. 1998 259 81.
35. 15N] nitrate in biological fluids. Anal. Biochem. 1982 126 : 131 8.
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951 193 : 265 75.
37. Konturek SJ, Konturek PC, Brzozowski T. Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. J. Physiol. Pharmacol. 2006 57 (Suppl. 5 51 66.
38. Phull PS, Green CJ, Jacyna MR. A radical view of the stomach: The role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease. Eur. J. Gastroenterol. Hepatol. 1995 7 : 265 74.
39. Brzozowski T, Konturek PC, Konturek SJ et al. The role of melatonin and l-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia and aspirin. J. Pineal Res. 1997 23 : 79 89.
40. Kato K, Murai I, Asai S et al. Protective role of melatonin and pineal gland in modulating water immersion restraint stress ulcer in rats. J. Clin. Gastroenterol. 1998 27 (Suppl. 1 S110 15.
41. Konturek PC, Konturek SJ, Majka J, Zembala H, Hahn EG. Melatonin affords protection against gastric lesions induced ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effect. Eur. J. Pharmacol. 1997 122 : 73 7.
42. Konturek PC, Konturek SJ, Brzozowski T et al. Gastroprotective activity of melatonin and its precursor, 1-tryptophan, against stress-induced and ischemia-induced lesions is mediated by scavenge of oxygen radicals. Scand. J. Gastroenterol. 1997 32 : 433 8.
43. 2 and ethanol. Am. J. Physiol. 1985 249 : G137 44.
44. Hoppenkamps R, Thies E, Younes M, Siegers CP. Glutathione and GSH-dependent enzymes in the human gastric mucosa. Klin. Wochenschr. 1984 62 : 183 6.
45. Hirota M, Inoue M, Ando Y et al. Inhibition of stress-induced gastric injury in the rat by glutathione. Gastroenterology 1989 97 : 853 9. (Pubitemid 19239020)
46. Martensson J, Jain A, Meister A. Glutathione is required for intestinal function. Proc. Natl Acad. Sci. USA 1990 87 : 1715 19.
47. Nagy L, Nagata M, Szabo S. Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents. World J. Gastroenterol. 2007 13 : 2053 60.
48. Okazaki M, Shimizu I, Ishikawa M et al. Gastric mucosal levels of prostaglandins and leukotrienes in patients with gastric ulcer after treatment with rabeprazole in comparison to treatment with ranitidine. J. Med. Invest. 2007 54 : 83 90.
49. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995 109 : 285 301.
50. Gyires K. Gastric mucosal protection: From prostaglandins to gene-therapy. Curr. Med. Chem. 2005 12 : 203 15.
51. Akbulut H, Akbulut KG, Gonul B. Malodialdehyde and glutathione in rats gastric mucosa and effects of exogenous melatonin. Dig. Dis. Sci. 1997 42 : 1381 8.
52. Bandyopadhyay D, Biswas K, Bandyopadhyay U, Reiter RJ, Banerjee R. Melatonin protects against stress-induced lesions by scavenging the hydroxyl radical. J. Pineal Res. 2000 29 : 143 51.
53. Cabeza J, Motilva V, Alercon de la Lastra CA. Mechanism involved in the gastric protection of melatonin on ischemia-reperfusion-induced oxidative damage in rats. Life Sci. 2001 68 : 1405 15.
54. Kargman S, Charleson S, Cartwright M et al. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology 1996 111 : 445 54.
55. Konturek SJ, Konturek PC, Brzozowski T. Prostaglandins and ulcer healing. J. Physiol. Pharmacol. 2005 56 (Suppl. 5 5 31.
56. Brzozowska I, Konturek PC, Brzozowski T et al. Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, l-tryptophan. J. Pineal Res. 2002 32 : 149 62.
57. Strieter RM, Kunkel SL, Showell HJ et al. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science 1989 243 : 1467 9.
58. Le J, Vilcek J. Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab. Invest. 1987 56 : 234 48.
59. Santucci L, Fiorucci S, Giansanti M, Brunori PM, Di Matteo FM, Morelli A. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: Role of tumour necrosis factor alpha. Gut 1994 35 : 909 15.
60. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991 32 : 1473 7.
61. Augusto AC, Miguel F, Mendonca S, Pedrazzoli Jr. J, Gurgueira SA. Oxidative stress expression in status associated to Helicobacter pylori virulence in gastric diseases. Clin. Biochem. 2007 40 : 615 22.
62. Hamaguchi M, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T. Mechanisms and roles of neutrophil infiltration in stress-induced gastric injury in rats. Dig. Dis. Sci. 2001 46 : 2708 15.
63. Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D. Effects of aloe vera and sucralfate on gastric microcirculartory changes, cytokine levels and gastric ulcer healing in rats. World J. Gastroenterol. 2006 12 : 2034 9.