Effects of gastric vagotomy on visceral cell proliferation induced by ventromedial hypothalamic lesions: Role of vagal hyperactivity

Journal of Molecular Neuroscience

Volumn 38, Issue 3, 2009, Pages 243-249

  Kintaka, Yuri ^a   Osaka, Toshimasa ^a   Suzuki, Yoko ^a   Hashiguchi, Takeo ^a   Niijima, Akira ^a   Kageyama, Haruaki ^a   Fumiko, Takenoya ^a   Shioda, Seiji ^a   Inoue, Shuji ^a,b  

^a KYORITSU WOMEN'S UNIVERSITY   (Japan)

^b KIRYU UNIVERSITY   (Japan)

Author keywords

Cell proliferation; Gastric acid; PCNA staining; Selective gastric vagotomy; Ventromedial hypothalamic (VMH) lesioned rats

Indexed keywords

ALCOHOL; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HIGHLY SELECTIVE VAGOTOMY; HYPOTHALAMUS LESION; LIVER; MITOSIS INDEX; NONHUMAN; PANCREAS; RAT; SMALL INTESTINE; STOMACH; STOMACH ACID SECRETION; STOMACH LESION; STOMACH MUCOSA LESION; ULCEROGENESIS; VAGUS NERVE; VAGUS NERVE STIMULATION; VISCERA; ZONA INCERTA; ANIMAL; CYTOLOGY; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INNERVATION; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT; STOMACH ACID; STOMACH MUCOSA; VAGOTOMY;

RATTUS;

ANIMALS; CELL PROLIFERATION; GASTRIC ACID; GASTRIC MUCOSA; INTESTINE, SMALL; LIVER; MALE; PANCREAS; RATS; RATS, SPRAGUE-DAWLEY; VAGOTOMY; VAGUS NERVE; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 68849122070     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9200-0     Document Type: Article

References (47)

1. Areche, C., Theoduloz, C., Yáñez, T., et al. (2008). Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls. The Journal of Pharmacy and Pharmacology, 60, 245-251. doi:10.1211/jpp.60.2.0014. (Pubitemid 351211841)
2. Bray, G. A., & York, D. A. (1979). Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiological Reviews, 59, 719-809.
3. Brzozowski, T., Konturek, P. C., Konturek, S. J., et al. (2003). Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin. International Journal of Colorectal Disease, 18, 320-329.
4. Brzozowski, T., Konturek, P. C., Chlopicki, S., et al. (2008). Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves. The Journal of Pharmacology and Experimental Therapeutics, 326, 105-116. doi:10.1124/jpet.108.136457. (Pubitemid 351872128)
5. Evangelista, S. (2006). Role of sensory neurons in restitution and healing of ulcers. Current Pharmaceutical Design, 12, 2977-2984. doi:10.2174/138161206777947632. (Pubitemid 44184630)
6. Ferguson, A. V., Marcus, P., Spencer, J., & Wallace, J. L. (1988). Paraventricular nucleus stimulation causes gastroduodenal mucosal necrosis in the rat. The American Journal of Physiology, 255, R861-R865.
7. Grijalva, C. V., Deregnaucourt, J., Code, C. F., & Novin, D. (1980). Gastric mucosal damage in rats induced by lateral hypothalamic lesions: protection by propantheline, cimetidine, and vagotomy. Proceedings of the Society for Experimental Biology and Medicine, 163, 528-533.
8. Gyires, K. (2005). Gastric mucosal protection: from prostaglandins to gene-therapy. Current Medicinal Chemistry, 12, 203-215.
9. Hall, P. A., Levison, D. A., Woods, A. L., et al. (1990). Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. The Journal of Pathology, 162, 285-294. doi:10.1002/path.1711620403.
10. Ham, M., & Kaunitz, J. D. (2007). Gastroduodenal defense. Current Opinion in Gastroenterology, 23, 607-616. doi:10.1097/MOG.0b013e3282f02607. (Pubitemid 47508789)
11. Ham, M., & Kaunitz, J. D. (2008). Gastroduodenal mucosal defense. Current Opinion in Gastroenterology, 24, 665-673. doi:10.1097/MOG. 0b013e328311cd93.
12. Hatazawa, R., Tanaka, A., Tanigami, M., et al. (2007). Cyclooxygenase-2 / prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors. American Journal of Physiology. Gastrointestinal and Liver Physiology, 293, 88-97. doi:10.1152/ajpgi.00131.2007. (Pubitemid 47605917)
13. Hawkey, C. J., & Langman, M. J. (2003). Non-steroidal antiinflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors. Gut, 52, 600-608. doi:10.1136/gut.52.4.600. (Pubitemid 36363420)
14. Hernández-Muñoz, R., Montiel-Ruíz, C., & Vázquez-Martínez, O. (2000). Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Laboratory Investigation, 80, 1161-1169. doi:10.1038/labinvest.3780124.
15. Hoffmann, W. (2008). Regeneration of the gastric mucosa and its glands from stem cells. Current Medicinal Chemistry, 15, 3133-3144. doi:10.2174/092986708786848587.
16. Hyde, T. M., & Crook, J. M. (2001). Cholinergic systems and schizophrenia: primary pathology or epiphenomena? Journal of Chemical Neuroanatomy, 22, 53-63. doi:10.1016/S0891-0618(01)00101-106
17. Inoue, S. (1992) Animal model of Obesity: hypothalamic lesions, in Obesity 1st Ed, P. Bjorntorp B. B., ed., J. P. Lippincott, Philadelphia, NJ, pp. 226-277.
18. Inoue, S., & Bray, G. A. (1979). Autonomic hypothesis for hypothalamic obesity. Life Sciences, 25, 561-566. doi:10.1016/0024-3205(79) 90549-90556
19. Inoue, S., Bray, G. A., & Mullen, Y. S. (1977a). Effect of transplantation of pancreas on development of hypothalamic obesity. Nature, 266, 742-744. doi:10.1038/266742a0.
20. Inoue, S., Campfield, L. A., & Bray, G. A. (1977b). Comparison of metabolic alterations in hypothalamic and high fat diet-induced obesity. The American Journal of Physiology, 233, R162-R168.
21. Kageyama, H., Kageyama, A., Endo, Y., et al. (2003). Ventromedial hypothalamus lesions induce jejunal epithelial cell hyperplasia through an increase in gene expression of cyclooxygenase. International Journal of Obesity and Related Metabolic Disorders, 27, 1006-1013. doi:10.1038/sj.ijo.0802325. (Pubitemid 37059604)
22. Kaneko, H., Mitsuma, T., Nagai, H., et al. (1998). Central action of adrenomedullin to prevent ethanol-induced gastric injury through vagal pathways in rats. The American Journal of Physiology, 274, R1783-R1788.
23. Kato, K., Yang, H., & Tache, Y. (1995). Low doses of TRH analogue act in the dorsal motor nucleus to induce gastric protection in rats. The American Journal of Physiology, 269, R1301-R1307.
24. Kargman, S., Charleson, S., Cartwright, M., et al. (1996). Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology, 111, 445-454. doi:10.1053/gast.1996.v111.pm8690211. (Pubitemid 26256734)
25. Kiba, T., Tanaka, K., Endo, O., & Inoue, S. (1992). Role of vagus nerve in increased DNA synthesis after hypothalamic ventromedial lesions in rat liver. The American Journal of Physiology, 262, G483-G487.
26. Kiba, T., Tanaka, K., Endo, O., & Inoue, S. (1993). Ventromedial hypothalamic lesions increase gastrointestinal DNA synthesis through vagus nerve in rats. Gastroenterology, 104, 475-484. (Pubitemid 23033420)
27. Kiba, T., Tanaka, K., Numata, K., Hoshino, M., Misugi, K., & Inoue, S. (1996). Ventromedial hypothalamic lesion-induced vagal hyperactivity stimulates rat pancreatic cell proliferation. Gastroenterology, 110, 885-893. doi:10.1053/gast.1996.v110.pm8608899. (Pubitemid 26071856)
28. Konturek, S. J., Konturek, P. C., & Brzozowski, T. (2005). Prostaglandins and ulcer healing. Journal of Physiology and Pharmacology, 56(Suppl 5), 5-31.
29. Lindholm, E., Shumway, G. S., Grijalva, C. V., Schallert, T., & Ruppel, M. (1975). Gastric pathology produced by hypothalamic lesions in rats. Physiology & Behavior, 14, 165-169. doi:10.1016/0031-9384(75)90161-4.
30. Malara, B., Joko, J., Tyrpie, M., Malara, P., & Steplewska, K. (2005). Dynamics of changes in vascular endothelial growth factor (VEGF) expression and angiogenesis in stress-induced gastric ulceration in rats. Journal of Physiology and Pharmacology, 56, 59-71.
31. Ohta, Y., Kobayashi, T., Nishida, K., Sasaki, E., & Ishiguro, I. (1999). Preventive effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on the development of stress-induced acute gastric mucosal lesions in rats. Journal of Ethnopharmacology, 67, 377-384. doi:10.1016/S0378-8741(99)00093-8. (Pubitemid 29469751)
32. Powley, T., & Opsahl, C. (1974). Ventromedial hypothalamic obesity abolished by subdiaphragmatic vagotomy. The American Journal of Physiology, 226, 25-33.
33. Ridley, P. T., & Brooks, F. P. (1965). Alterations in Gastric Secretion Following Hypothalamic Lesions Producing Hyperphagia. The American Journal of Physiology, 209, 319-323.
34. Saftoiu, A., Ciurea, T., Georgescu, C., et al. (2003). Immunohistochemical assessment of proliferating cell nuclear antigen in primary hepatocellular carcinoma and dysplastic nodules. Journal of Cellular and Molecular Medicine, 7, 436-446. doi:10.1111/j.1582-4934.2003.tb00246.x.
35. Sibilia, V., Rindi, G., Pagani, F., et al. (2003). Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology, 144, 353-359. doi:10.1210/en.2002220756.
36. Sibilia, V., Pagani, F., Lattuada, N., et al. (2007). Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. Pharmacological Research, 55, 418-425. doi:10.1016/j.phrs.2007.01. 017. (Pubitemid 46560394)
37. Suga, A., Hirano, T., Kageyama, H., et al. (1999). Rapid increase in circulating leptin in ventromedial hypothalamus-lesioned rats: role of hyperinsulinemia and implication for upregulation mechanism. Diabetes, 48, 2034-2038. doi:10.2337/diabe tes.48.10.2034.
38. Szolcsányi, J., & Barthó, L. (2001). Capsaicin-sensitive afferents and their role in gastroprotection: an update. Journal of physiology (Paris), 95, 181-188. doi:10.1016/S0928-4257(01)00023-7. (Pubitemid 33020235)
39. Tanaka, K., Ohkawa, S., Nishino, T., Niijima, A., & Inoue, S. (1987). Role of the hepatic branch of the vagus nerve in liver regeneration in rats. The American Journal of Physiology, 253, G439-G444.
40. Tanaka, T., Guth, P., & Taché, Y. (1993). Role of nitric oxide in gastric hyperemia induced by central vagal stimulation. The American Journal of Physiology, 264, G280-G284. (Pubitemid 23069589)
41. Tominaga, S., Satoh, S., Nagase, H., Tanaka, K., & Inoue, S. (1993). Hypergastric acid secretion in rats with ventromedial hypothalamic lesions. Physiology & Behavior, 153, 1177-1182. doi:10.1016/0031-9384(93)90376-Q. (Pubitemid 23167538)
42. Vanhatalo, S., & Soinila, S. (2001). Evidence for nodose ganglion as the source of innervation to the anterior lobe of the pituitary gland. Neuroscience, 107, 491-497. doi:10.1016/S0306-4522(01)00367-370
43. Yang, H., Kawakubo, K., & Tache, Y. (1999). Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways. The American Journal of Physiology, 277, G555-G562.
44. Yeomans, N. D., Skeljo, M. V., & Giraud, A. S. (1994). Gastric mucosal defensive factors: the therapeutic strategy. Journal of Gastroenterology and Hepatology, 9(Suppl 1), S104-S108. doi:10.1111/j.1440-1746.1994.tb01312.x.
45. Yoshimatsu, H., Niijima, A., Oomura, Y., et al. (1984). Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. Brain Research, 303, 147-152. doi:10.1016/0006-8993(84)90222-90231
46. Zhang, J. F., & Zheng, F. (1997). The role of paraventricular nucleus of hypothalamus in stress-ulcer formation in rats. Brain Research, 761, 203-209. doi:10.1016/S0006-8993(97)00257-6. (Pubitemid 27316687)
47. Zhou, S. Y., Lu, Y. X., Owyang, C., et al. (2008). Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat. American Journal of Physiology. Gastrointestinal and Liver Physiology, 294, 1158-1164. doi:10.1152/ajpgi.00067.2008.