Efficient characterization of the TCR repertoire in lymph nodes by flow cytometry

Cytometry Part A

Volumn 75, Issue 9, 2009, Pages 743-751

  Salameire, D ^a,b,c,d   Le Bris, Y ^a,d,e   Fabre, B ^b,c,d   Fauconnier, J ^d   Solly, F ^a,b,c,d   Pernollet, M ^d,e   Bonnefoix, T ^b,c,d   Leroux, D ^a,b,c,d   Plumas, J ^a,b,c,e   Jacob, Marie Christine ^b,c,e  

^a UNIV GRENOBLE ALPES   (France)

^b INSTITUT ALBERT BONNIOT   (France)

^c Oncogenic Pathways in Haematological Malignancies ^*  (France)

^d HÔPITAL MICHALLON   (France)

^e ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

Flow cytometry, V antibodies; Immunology; Lymph nodes; T cell repertoire

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; LYMPH NODE CELL; LYMPHOCYTE HOMING; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; FEMALE; FLOW CYTOMETRY; HODGKIN DISEASE; HUMANS; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PSEUDOLYMPHOMA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REFERENCE VALUES; YOUNG ADULT;

EID: 68849114265     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20767     Document Type: Article

References (45)

1. Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: Directing lymphocyte traffic in the lymph node. Trends Immunol 2007;28:346-352. (Pubitemid 47077926)
2. Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: Chemokines in control of T cell traffic. Nat Immunol 2008;9:970-980.
3. Meggetto F, al Saati T, Rubin B, Delsol G. Lack of restricted T-cell receptor beta-chain variable region (V beta) usage of reactive T-lymphocytes in Hodgkin's disease. Br J Haematol 1994;86:524-532. (Pubitemid 24199040)
4. Xerri L, Mathoulin MP, Birg F, Bouabdallah R, Stoppa AM, Hassoun J. Heterogeneity of rearranged T-cell receptor V-alpha and V-beta transcripts in tumor-infiltrating lymphocytes from Hodgkin's disease and non-Hodgkin's lymphoma. Am J Clin Pathol 1994;101:76-80. (Pubitemid 24030380)
5. Kostense S, Raaphorst FM, Joling J, Notermans DW, Prins JM, Danner SA, Reiss P, Lange JM, Teale JM, Miedema F. T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: Effect of antiretroviral therapy. AIDS 2001;15:1097-1107. (Pubitemid 32549860)
6. Ito K, Fetten J, Khalili H, Hajdu S, Busch E, Pergolizzi R, Vinciguerra V, Chang MD. Oligoclonality of CD81 T cells in breast cancer patients. Mol Med 1997;3:836-851. (Pubitemid 28086580)
7. Mion M, Indraccolo S, Feroli F, Minuzzo S, Masiero S, Zamarchi R, Barelli A, Borri A, Chieco-Bianchi L, Amadori A. TCR expression and clonality analysis in peripheral blood and lymph nodes of HIV-infected patients. Hum Immunol 1997;57:93-103. (Pubitemid 28020906)
8. Willenbrock K, Roers A, Blohbaum B, Rajewsky K, Hansmann ML. CD8(1) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen. Am J Pathol 2000;157:171-175.
9. Baner J, Marits P, Nilsson M, Winqvist O, Landegren U. Analysis of T-cell receptor V beta gene repertoires after immune stimulation and in malignancy by use of padlock probes and microarrays. Clin Chem 2005;51:768-775. (Pubitemid 40463929)
10. Fuschiotti P, Pasqual N, Hierle V, Borel E, London J, Marche PN, Jouvin-Marche E. Analysis of the TCR alpha-chain rearrangement profile in human T lymphocytes. Mol Immunol 2007;44:3380-3388. (Pubitemid 46695752)
11. van den Beemd R, Boor PP, van Lochem EG, Hop WC, Langerak AW, Wolvers- Tettero IL, Hooijkaas H, van Dongen JJ. Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 2000;40:336-345. (Pubitemid 30643192)
12. MacIsaac C, Curtis N, Cade J, Visvanathan K. Rapid analysis of the Vbeta repertoire of CD4 and CD8 T lymphocytes in whole blood. J Immunol Methods 2003;283:9-15. (Pubitemid 37501055)
13. Li Y, Braylan RC, Al-Quran SZ. Flow-cytometric assessment of T-cell clonality in clinical specimens. Lab Med 2007;38:477-482. (Pubitemid 47206325)
14. Wahlstrom J, Berlin M, Lundgren R, Olerup O, Wigzell H, Eklund A, Grunewald J. Lung and blood T-cell receptor repertoire in extrinsic allergic alveolitis. Eur Respir J 1997;10:772-779. (Pubitemid 27180186)
15. Hedlund-Treutiger I, Elinder G, Wigzell H, Grunewald J, Wahlstrom J. T cell receptor V gene usage by CD41 and CD81 peripheral blood T lymphocytes in immune thrombocytopenic purpura. Acta Paediatr 2004;93:633-637. (Pubitemid 38570230)
16. Popa ER, Stegeman CA, Bos NA, Kallenberg CG, Tervaert JW. Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis. Clin Exp Immunol 2003;132:496-504.
17. Englund P, Wahlstrom J, Fathi M, Rasmussen E, Grunewald J, Tornling G, Lundberg IE. Restricted T cell receptor BV gene usage in the lungs and muscles of patients with idiopathic inflammatory myopathies. Arthritis Rheum 2007;56:372-383. (Pubitemid 46106211)
18. Nozawa H, Takahara M, Yoshizaki T, Goto T, Bandoh N, Harabuchi Y. Selective expansion of T cell receptor (TCR) V beta 6 in tonsillar and peripheral blood T cells and its induction by in vitro stimulation with Haemophilus parainfluenzae in patients with IgA nephropathy. Clin Exp Immunol 2008;151:25-33. (Pubitemid 350230980)
19. Brogan PA, Shah V, Bagga A, Klein N, Dillon MJ. T cell Vbeta repertoires in childhood vasculitides. Clin Exp Immunol 2003;131:517-527. (Pubitemid 36324144)
20. Conley DB, Tripathi A, Seiberling KA, Schleimer RP, Suh LA, Harris K, Paniagua MC, Grammer LC, Kern RC. Superantigens and chronic rhinosinusitis: Skewing of Tcell receptor V beta-distributions in polyp-derived CD41 and CD81 T cells. Am J Rhinol 2006;20:534-539. (Pubitemid 44575721)
21. Conley DB, Tripathi A, Seiberling KA, Suh LA, Harris KE, Paniagua MC, Grammer LC, Kern RC. Superantigens and chronic rhinosinusitis II: Analysis of T-cell receptor V beta domains in nasal polyps. Am J Rhinol 2006;20:451-455. (Pubitemid 44390225)
22. Lima M, Teixeira Mdos A, Queiros ML, Santos AH, Goncalves C, Correia J, Farinha F, Mendonca F, Soares JM, Almeida J, Orfão A, Justiça B. Immunophenotype and TCR-Vbeta repertoire of peripheral blood T-cells in acute infectious mononucleosis. Blood Cells Mol Dis 2003;30:1-12. (Pubitemid 36378863)
23. Clarencio J, de Oliveira CI, Bomfim G, Pompeu MM, Teixeira MJ, Barbosa TC, Souza-Neto S, Carvalho EM, Brodskyn C, Barral A, Barral-Netto M. Characterization of the T-cell receptor Vbeta repertoire in the human immune response against Leishmania parasites. Infect Immun 2006;74:4757-4765. (Pubitemid 44160177)
24. Albers AE, Visus C, Tsukishiro T, Ferris RL, Gooding W, Whiteside TL, De Leo AB. Alterations in the T-cell receptor variable beta gene-restricted profile of CD81 T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2006;12:2394-2403.
25. Raitakari M, Brown RD, Sze D, Yuen E, Barrow L, Nelson M, Pope B, Esdale W, Gibson J, Joshua DE. T-cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells. Br J Haematol 2000;110:203-209. (Pubitemid 30625609)
26. Pierdominici M, Mazzetta F, Caprini E, Marziali M, Digilio MC, Marino B, Aiuti A, Amati F, Russo G, Novelli G, Pandolfi F, Luzi G, Giovannetti A. Biased T-cell receptor repertoires in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/ velocardiofacial syndrome). Clin Exp Immunol 2003;132:323-331. (Pubitemid 36560631)
27. Gennery AR, Hodges E, Williams AP, Harris S, Villa A, Angus B, Cant AJ, Smith JL. Omenn's syndrome occurring in patients without mutations in recombination activating genes. Clin Immunol 2005;116:246-256. (Pubitemid 41112728)
28. Langerak AW, van Den Beemd R, Wolvers-Tettero IL, Boor PP, van Lochem EG, Hooijkaas H, van Dongen JJ. Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations. Blood 2001;98:165-173.
29. Beck RC, Stahl S, O'Keefe CL, Maciejewski JP, Theil KS, Hsi ED. Detection of mature T-cell leukemias by flow cytometry using anti-T-cell receptor V beta antibodies. Am J Clin Pathol 2003;120:785-794.
30. Rappl G, Muche JM, Abken H, Sterry W, Tilgen W, Ugurel S, Reinhold U. CD4(1)CD7(-) T cells compose the dominant T-cell clone in the peripheral blood of patients with Sezary syndrome. J Am Acad Dermatol 2001;44:456-461.
31. Morice WG, Kimlinger T, Katzmann JA, Lust JA, Heimgartner PJ, Halling KC, Hanson CA. Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: A comparison with conventional T-cell immunophenotyping and molecular genetic techniques. Am J Clin Pathol 2004;121:373-383. (Pubitemid 38298171)
32. Karimzadeh K, Morrison J, Zadeh HH. Comparison of gingival and peripheral blood T cells among patients with periodontitis suggests skewing of the gingival T cell antigen receptor V beta repertoire. J Periodontal Res 1999;34:445-456.
33. Berglundh T, Liljenberg B, Tarkowski A, Lindhe J. Local and systemic TCR V gene expression in advanced periodontal disease. J Clin Periodontol 1998;25:125-133. (Pubitemid 128705943)
34. Derniame S, Vignaud JM, Faure GC, Bene MC, Massin F. Comparative T-cell oligoclonality in lung, tumor and lymph nodes in human non-small cell lung cancer. Oncol Rep 2005;13:509-515.
35. Tripathi A, Kern R, Conley DB, Seiberling K, Klemens JC, Harris KE, Suh L, Huang J, Grammer LC. Staphylococcal exotoxins and nasal polyposis: Analysis of systemic and local responses. Am J Rhinol 2005;19:327-333. (Pubitemid 41341771)
36. Battaglia A, Ferrandina G, Buzzonetti A, Malinconico P, Legge F, Salutari V, Scambia G, Fattorossi A. Lymphocyte populations in human lymph nodes. Alterations in CD41 CD251 T regulatory cell phenotype and T-cell receptor Vbeta repertoire. Immunology 2003;110:304-312.
37. Ramzaoui S, Jouen-Beades F, Michot F, Borsa-Lebas F, Humbert G, Tron F. Comparison of activation marker and TCR V beta gene product expression by CD41 and CD81 T cells in peripheral blood and lymph nodes from HIV-infected patients. Clin Exp Immunol 1995;99:182-188.
38. Valmori D, Dutoit V, Lienard D, Lejeune F, Speiser D, Rimoldi D, Cerundolo V, Dietrich PY, Cerottini JC, Romero P. Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD81 T cells in melanoma patients. J Immunol 2000;165:533-538. (Pubitemid 30429548)
39. Brogan PA, Shah V, Clarke LA, Dillon MJ, Klein N. T cell activation profiles in Kawasaki syndrome. Clin Exp Immunol 2008;151:267-274.
40. Bosboom WM, Van den Berg LH, Mollee I, Sasker LD, Jansen J, Wokke JH, Logtenberg T. Sural nerve T-cell receptor Vbeta gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy. Neurology 2001;56:74-81. (Pubitemid 32059655)
41. Nityanand S, Giscombe R, Srivastava S, Hjelmstrom P, Sanjeevi CB, Sinha N, Grunewald J, Lefvert AK. A bias in the alphabeta T cell receptor variable region gene usage in Takayasu's arteritis. Clin Exp Immunol 1997;107:261-268. (Pubitemid 27049251)
42. Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy". J Exp Med 1994;179:609-618.
43. Clambey ET, van Dyk LF, Kappler JW, Marrack P. Non-malignant clonal expansions of CD81 memory T cells in aged individuals. Immunol Rev 2005;205:170-189. (Pubitemid 40780185)
44. Clambey ET, Kappler JW, Marrack P. CD8 T cell clonal expansions & aging: A heterogeneous phenomenon with a common outcome. Exp Gerontol 2007;42:407-411. (Pubitemid 46561175)
45. Delfau-Larue MH, Laroche L, Wechsler J, Lepage E, Lahet C, Asso-Bonnet M, Bagot M, Farcet JP. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000;96:2987-2992. (Pubitemid 30815204)