Comparison of gingival and peripheral blood T cells among patients with periodontitis suggests skewing of the gingival T cell antigen receptor Vβ repertoire

Journal of Periodontal Research

Volumn 34, Issue 8, 1999, Pages 445-456

  Karimzadeh, Kian ^b   Morrison, John ^b   Zadeh, Homayoun H ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

Gingiva; Periodontitis; Superantigens; T cell receptor; T cells; V

Indexed keywords

CD45 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SEPARATION; COMPARATIVE STUDY; CYTOLOGY; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GINGIVA; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTITIS; STATISTICS;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; GINGIVA; HUMANS; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTITIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0033218214     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1999.tb02280.x     Document Type: Article

References (36)

1. Seymour GJ, Powell RN, Davies WIR. Conversion of a stable T-cell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: an hypothesis. J Clin Periodontol 1979;6:267-277.
2. Stoufi ED, Taubman MA, Ebersole JL, Smith DJ. Preparation and characterization of human gingival cells. J Periodont Res 1987;22:144-149.
3. Stoufi ED, Taubman MA, Ebersole JL, Smith DJ, Stashenko PP. Phenotypic analyses of mononuclear cells recovered from healthy and diseased periodontal tissues. J Clin Immunol 1987;7:235-245.
4. Malberg K, Mölle A, Streuer D, Gängler P. Determination of lymphocyte populations and subpopulations extracted from chronically inflamed human periodontal tissues. J Clin Periodontol 1992;19:155-158.
5. Meng HX, Zheng LF. T cells and T cell subsets in periodontal disease. J Periodont Res 1989;24:121-126.
6. Reinhardt RA, Bolton MS, MCDONALD TL, DuBois LM, Kaldahl WB. In situ lymphocyte subpopulations from active versus stable periodontal sites. J Periodontol 1988; 59:656-670.
7. Gemmell E, Feldner B, Seymour GJ. CD45RA and CD45RO positive CD4 cells in human peripheral blood and periodontal disease tissue before and after stimulation with periodontopathic bacteria. Oral Microbiol Immunol 1992;7:84-88.
8. Yamashita K, Eastcott J, Taubman M, Smith D, Cox D. Effect of adoptive transfer of cloned Actinobacillus actinomycetemcomitans-specific T helper cells on periodontal disease. Infect Immun 1991;59:1529-1534.
9. Rowen L, Koop BF, Hood L. The complete 685-kilobase DNA sequence of the human T cell receptor locus. Science 1996;272:1755-1762.
10. Choi BY, Lafferty JA, Clements JR et al. Selective expansion of T cells expressing V beta 2 in toxic shock syndrome. J Exp Med 1990;172:981-984.
11. Broker B, Korthauer U, Heppt P et al. Biased T cell receptor V gene usage in rhuematiod arthtitis. Arthritis Rheum 1993;36:1234-1243.
12. Paliard X, West SG, Lafferty JA, Kappler JW, Marrack P, Kotzin BL. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 1991;253:325-329.
13. Conrad B, Weldman E, Trucco G et al. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 1994;371:351-355.
14. Ohmen J, Barnes P, Grisso C, Bloom B, Modlin R. Evidence for a superantigen in human tuberculosis. Immunity 1994;1:35-43.
15. Abe J, Kotzin BL, Jujo K et al. Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease. Proc Natl Acad Sci USA 1992;89:4066-4070.
16. Freidman SM, Posnett DN, Tumang JR, Cole BC, Crow MK. A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease. Arthritis Rheum 1991;34:468-480.
17. Posnett DN, Schmelkin I, Burton DA, August A, McGrath H, Mayer LF. T cell receptor V gene usage: increases in Vbeta8 + T cells in Crohn's disease. J Clin Invest 1990;85: 1770-1776.
18. Laurence J, Hodtsev AS, Posnett DN. Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression. Nature 1992;358:255-259.
19. Laurence J, Hodtsev AS, Posnett DN. Superantigens in infectious diseases, including AIDS. Ann NY Acad Sci 1993; 685:746-755.
20. Bisste LR. Looking for a 'superantigen' in AIDS: a possible role for Mycoplasma? Med Hypothesis 1993;40:146-153.
21. Zadeh H, Kreutzer D. Evidence for involvement of superantigens in human periodontal diseases: skewed expressior of T cell receptor variable regions by gingival T cells. Oral Microbiol Immunol 1996;11:88-95.
22. Yamazaki K, Nakajima T, Gemmell E, Kjeldsen M, Seymour G, Hara K. Biased expression of T cell receptor V beta genes in periodontitis patients. Clin Exp Immunol 1996;106:329-335.
23. Karimzadeh K, Zadeh HH, Kreutzer DL. Dominant expression of T Cell receptor Vβ regions among isolated gingival T cells suggests local stimulation by superantigens. J Dent Res 1995;74:62.
24. Gemmell E, Grieco D, Yamazaki K, Nakajima T, Seymour G. Expression of receptor beta-chain variable region by T cells in human periodontal disease. Arch Oral Biol 1997;42:683-694.
25. Seymour GJ, Gemmel E, Reinhardt R, Eastcott J, Taubman M. Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms. J Periodont Res 1993;28:478-486.
26. Berglundh T, Liljenberg B, Tarkowski A et al. Local and systemic TCR V gene expression in advanced periodontal disease. J Clin Periodontol 1998;25:125-133.
27. Nakajima T, Yamazaki K, Hara K. Biased T cell receptor V gene usage in tissues with periodontal disease. J Periodont Res 1996;31:2-10.
28. Zadeh H, Slots J, Kreutzer D. Analysis of early responding T cells suggests expression of a superantigen by A. actinomycetemcomitans. J Dent Res 1996;75S: (abstr 1115).
29. Mathur A, Michalowicz B, Yang C, Aeppli D. Influence of periodontal bacteria and disease status on V beta expression in T cells. J Periodont Res 1995;30:369-373.
30. Kotzin BL, Satyanarayana H, Chou YK et al. Preferential T-cell receptor β-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc Natl Acad Sci USA 1991;88: 9161-9165.
31. Stuart PM, Woodward JG. Yersinia enterocolitica produces superantigenic activity. J Immunol 1992;148: 225-229.
32. Miyoshi-Akiyama TIK, Uchiyama T. Purification and partial characterization of a product from Yersinia pseudotuberculosis with the ability to activate human T cells. Infect Immun 1993;61:3922-3927.
33. Bowness P, Moss PA, Tranter H, Bell JI, McMichael AJ. Clostridium perfringens enterotoxin is a superantigen reactive with human T cell receptors V beta 6.9 and V beta 22. J Exp Med 1992;176:893-896.
34. Lahesmaa R, Shanafelt MC, Allsup A et al. Preferential usage of T cell antigen receptor V region gene segment V beta 5.1 by Borrelia burgdorferi antigen-reactive T cell clones isolated from a patient with Lyme disease. J Immunol 1993;150:4125-4135.
35. Zadeh HH, F. C. Nichols et al. The role of the T cell-mediated immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontitis. Periodontol 2000 1999;20:239-288.
36. Nalbant A, Zadeh HH. Evidence for apoptosis of the majority of T cells activated in vitro with Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. in press.