Fatty acids increase paracellular absorption of aluminium across Caco-2 cell monolayers

Chemico-Biological Interactions

Volumn 181, Issue 2, 2009, Pages 272-278

  Aspenström Fagerlund, Bitte ^a,b   Sundström, Birgitta ^a   Tallkvist, Jonas ^b   Ilbäck, Nils Gunnar ^a,c   Glynn, Anders W ^a,c  

^a NATIONAL FOOD ADMINISTRATION   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Aluminium; Caco 2; Docosahexaenoic acid; Oleic acid; Paracellular absorption; Tight junctions

Indexed keywords

ALUMINUM; DOCOSAHEXAENOIC ACID; LACTATE DEHYDROGENASE; MANNITOL; OLEIC ACID;

ARTICLE; CELL STRAIN CACO 2; CELL STRUCTURE; CONTROLLED STUDY; DESMOSOME; ELECTRIC RESISTANCE; EMULSION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; PROTEIN CONTENT; TIGHT JUNCTION; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY;

ALUMINUM; CACO-2 CELLS; FATTY ACIDS; HUMANS; INTESTINAL ABSORPTION; MEMBRANE POTENTIALS; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 68849103470     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.06.016     Document Type: Article

References (48)

1. Mine Y., and Zhang J.W. Surfactants enhance the tight-junction permeability of food allergens in human intestinal epithelial Caco-2 cells. Int. Arch. Allergy Immunol. 130 (2003) 135-142
2. Ilbäck N.-G., Nyblom M., Carlfors J., Aspenström-Fagerlund B., Tavelin S., and Glynn A.W. Do surface active lipids in food increase the intestinal permeability to toxic substances and allergenic agents. Med. Hypoth. 63 (2004) 724-730
3. Brand R.M., Cetin Y., Mueller C., and Cuppett S.L. Effect of fatty acids on herbicide transport across Caco-2 cell monolayers. Toxicol. In Vitro 19 (2005) 595-601
4. Anderberg E.K., Lindmark T., and Artursson P. Sodium carprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10 (1993) 857-864
5. Lindmark, Schipper N., Lazarová L., de Boer A.G., and Artursson P. Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes. J. Drug Target. 5 (1998) 215-223
6. Usami M., Muraki K., Iwamoto M., Ohata A., Matsushita E., and Miki A. Effect of eicosapentaenoic acid (EPA) on tight junction permeability in intestinal mono layer cells. Clin. Nutr. 20 (2001) 351-359
7. Droke E.A., Briske-Andersson M., and Lukaski H.C. Fatty acids alter monolayer integrity, paracellular transport, and iron uptake and transport in Caco-2 cells. Biol. Trace Elements Res. 95 (2003) 219-232
8. Aspenström-Fagerlund B., Ring L., Aspenström P., Tallkvist J., Ilbäck N.-G., and Glynn A.W. Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. Toxicology 237 (2007) 12-23
9. Greger J.L., and Sutherland J.E. Aluminium exposure and metabolism. Crit. Rev. Clin. Lab. Sci. 34 (1997) 439-474
10. Yokel R.A., Hicks C.L., and Florence R.L. Aluminium bioavailability from basic sodium aluminium phosphate, an approved food additive emulsifying agent, incorporated in cheese. Food Chem. Toxicol. 46 (2008) 2261-2266
11. Jorhem L., and Haegglund G. Aluminium in foodstuffs and diets in Sweden. Z. Lebensm. Unters. Forsch. 194 (1992) 38-42
12. Liukkonen-Lilja H., and Piepponen S. Leaching of aluminium from aluminium dishes and packages. Food Addit. Contam. 9 (1992) 213-223
13. EMEA, Summary Report for Aluminium distearate, Aluminium Hydroxide Acetate, Aluminium Phosphate and Aluminium Tristearate (EMEA/MRL/393/98-Final), http://www.emea.europa.eu.
14. FAO/WHO, Summary and conclusions of the 67th meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), Safety evaluation of certain food additives and contaminants, Aluminium from all sources, including food additives, WHO FOOD Additives Series 58 (2006) 119-208.
15. EFSA. Scientific opinion of the panel on food additives, flavourings, processing aids and food contact materials on a request from European Commission on safety of aluminium from dietary intake. EFSA J. 754 (2008) 1-4
16. Yokel R.A., and Mc Namara P.J. Aluminium toxicokinetics: an updated minireview. Pharmacol. Toxicol. 88 (2001) 159-167
17. Provan S.D., and Yokel R.A. Aluminium uptake by the in situ rat gut preparation. J. Pharmacol. Exp. Ther. 245 (1988) 928-931
18. Whitehead M.W., Farrar G., Christie G.L., Blair J.A., and Thompson R.P.H. Mechanisms of aluminium absorption in rats. Am. J. Clin. Nutr. 65 (1997) 1446-1452
19. Zhou Y., and Yokel R.A. The chemical species of aluminium influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption. Toxicol. Sci. 87 (2005) 15-26
20. Slanina P., French W., Ekström L.-G., Lööf L., Slorach S., and Cedergren A. Dietary citric acid enhances absorption of aluminium in antacids. Clin. Chem. 32 (1986) 539-541
21. Froment D.P.H., Molitoris B.A., Buddington B., Miller N., and Alfrey A.C. Site and mechanism of enhanced gastrointestinal absorption of aluminium by citrate. Kidney Int. 36 (1989) 978-984
22. Alvarez-Hernandez X., Madigosky S.R., Stewart B., and Glass J. Iron status affects aluminium uptake and transport by Caco-2 cells. J. Nutr. 124 (1994) 1574-1580
23. Cunat L., Lanhers M.-C., Joyeux M., and Burnel D. Bioavailability and intestinal absorption of aluminium in rats, effects of aluminium compounds and some dietary constituents. Biol. Trace Elements Res. 76 (2000) 31-55
24. Glynn A.W., Sparén A., Danielsson L.G., Sundstrom B., and Jorhem L. The influence of complexing agents on the solubility and absorption of aluminium in rats exposed to aluminium in water. Food Addit. Contam. 18 (2001) 515-523
25. 14C study. J. Inorg. Biochem. 102 (2008) 798-808
26. Artursson P., Ungell A.-L., and Löfroth J.-E. Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res. 10 (1993) 1123-1129
27. Watson C.J., Rowland M., and Warhurst G. Functional modelling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers. Am. J. Physiol. Cell Physiol. 281 (2001) 388-397
28. Cano-Cebrián M.J., Zornoza T., Granero L., and Polache A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr. Drug Deliv. 2 (2005) 9-22
29. Blais A., Lecoeur S., Milhaud G., Tomé D., and Kolf-Clauw M. Cadmium uptake and transepithelial transport in control and long-term exposed Caco-2 cells: the role of metallothionein. Toxicol. Appl. Pharmacol. 160 (1999) 76-85
30. Pinto M., Robine-Leon S., Appay M.-D., Kedinger M., Triadou N., Dussaulx E., Lacroix B., Simon-Assmann P., Haffen K., Fogh J., and Zweibaum A. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell 47 (1983) 323-330
31. Artursson P., Palm K., and Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Deliv. Rev. 46 (2001) 27-43
32. Delie F., and Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit. Rev. Ther. Drug Carrier Syst. 14 (1997) 221-286
33. Hartree E.F. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal. Biochem. 48 (1972) 422-427
34. Lindmark T., Nikkilä T., and Artursson P. Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 275 (1995) 958-964
35. Pennsiton K.L., Nakada S.Y., Holmes R.P., and Assimos D.G. Quantitative assessment of citric acids in lemon juice, lime juice, and commercially available fruit juice products. J. Endourol. 22 (March) (2008) 567-570
36. Medical product Agency in Sweden, www.lakemedelsverket.se.
37. Gräske A., Thuvander A., Johannisson A., Gadhasson I., Schütz A., Festin R., and Wicklund Glynn A. Influence of aluminium on the immune system-an experimental study on volunteers. Biometals 13 (2000) 123-133
38. 2+ in cultured epithelia. Biochem. Biophys. Acta 1222 (1994) 147-158
39. Hayashi M., and Tomita M. Mechanistic analysis for drug permeation through intestinal membrane. Drug Metab. Pharmacokinet. 22 (2007) 67-77
40. Kvietys P.R., Specian R.D., Grisham M., and Tso P. Jejunal mucosa injury and restitution: role of hydrolytic products of food digestion. Am. J. Physiol. 261 (1991) G384-391
41. Kvietys P.R., Specian R.D., and Cepinskas G. Polyamines attenuate jejunal mucosal injury induced by oleic acid. Am. J. Physiol. 263 (1992) G224-G229
42. De Boer A.G. Drug Absorption Enhancement: Concepts, Possibilities, Limitations and Trends vol. 3 (1994), Harwood Academic Publishers, New York
43. Becker W., and Pearson M. Riksmaten 1997-1998, Nutritional Facts, Food and Health (2002), National Food Administration, Sweden
44. Rose D.P., and Connolly J.M. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol. Ther. 83 (1999) 217-244
45. Jiang W.G., Bryce R.P., and Horrobin D.F. Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Crit. Rev. Oncol./Hematol. 27 (1998) 179-209
46. Van Itallie C.M., Holmes J., Bridges A., Gookin J.L., Coccaro M.R., Proctor W., Colegio O.R., and Anderson J.M. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J. Cell Sci. 121 (2008) 298-305
47. Watson C.J., Hoare C.J., Garrod D.R., Carlson G.L., and Warhurst G. Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. J. Cell Sci. 118 (2005) 5221-5230
48. Krewski D., Yokel R.A., Nieboer E., Borchelt D., Cohen J., Harry J., Kacew S., Lindsay J., Mahfouz A.M., and Rondeau V. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J. Toxicol. Environ. Health: Crit. Rev. 10 Suppl. 1 (2007) 1-269