Dysregulation of gene expression within the peroxisome proliferator activated receptor pathway in morbidly obese patients

Surgical Endoscopy

Volumn 23, Issue 6, 2009, Pages 1292-1297

  Hindle, A Katharine ^a   Koury, Jadd ^a   McCaffrey, Tim ^a   Fu, Sidney W ^a   Brody, Fred ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bariatric; Obesity

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RNA;

ADULT; AGED; ARTICLE; BARIATRIC SURGERY; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; DOWN REGULATION; GENE AMPLIFICATION; GENE CLUSTER; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MORBIDITY; OBESITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; BLOOD; COMPARATIVE STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MORBID OBESITY; POLYMERASE CHAIN REACTION; PROGNOSIS; SIGNAL TRANSDUCTION;

ADULT; AGED; BODY MASS INDEX; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED; OBESITY, MORBID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PPAR GAMMA; PROGNOSIS; RNA; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 68849096070     PISSN: 09302794     EISSN: 14322218     Source Type: Journal    
DOI: 10.1007/s00464-008-0152-1     Document Type: Article

References (16)

1. Annual meeting of the North American Association for the Study of Obesity, October 29 to November 2, 2000. Long Beach, CA, USA (2000). Abstracts. Obes Res 8(Suppl 1):1S-138S
2. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS (2003) Prevalence of obesity, diabetes, and obesityrelated health risk factors, 2001. JAMA 289:76-79
3. Mokdad AH, Marks JS, Stroup DF, Gerberding JL (2004) Actual causes of death in the United States, 2000. JAMA 291:1238-1245
4. Mokdad AH, Marks JS, Stroup DF, Gerberding JL (2005) Correction: actual causes of death in the United States, 2000. JAMA 293:293-294
5. Kersten S, Desvergne B, Wahli W (2000) Roles of PPARs in health and disease. Nature 405:421-424
6. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM (2003) Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113:159-170
7. Heuvel J (2007) The PPAR resource page. Biochim Biophys Acta 1771:1108-1112
8. Brody F, Hill S, Celenski S, Kar R, Kluk B, Pinzone J, Fu S (2007) Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients. Surg Endosc 21:941-944
9. Mutch DM, Berger A, Mansourian R, Rytz A, Roberts MA (2002) The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data. BMC Bioinformatics 3:17
10. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724-1737
11. Jeffery IB, Higgins DG, Culhane AC (2006) Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data. BMC Bioinformatics 7:359
12. Evans RM, Barish GD, Wang YX (2004) PPARs and the complex journey to obesity. Nat Med 10:355-361
13. Grimble RF (2002) Inflammatory status and insulin resistance. Curr Opin Clin Nutr Metab Care 5:551-559
14. Ogden CL, Yanovski SZ, Carroll MD, Flegal KM (2007) The epidemiology of obesity. Gastroenterology 132:2087-2102
15. Wilding JP (2007) The importance of free fatty acids in the development of type 2 diabetes. Diabet Med 24:934-945
16. Maclaren R, Cui W, Simard S, Cianflone K (2008) Influence of obesity and insulin sensitivity on insulin-signaling genes in human omental and subcutaneous adipose tissue. J Lipid Res 49:308-323