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Volumn 45, Issue 5, 2000, Pages 351-361

Modulation of plasma uridine concentration by 5- (phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: Relevance to chemotherapy

Author keywords

5 (Phenylselenenyl)acyclouridine; Chemotherapy; Uridine phosphorylase

Indexed keywords

5 (PHENYLSELENENYL)ACYCLOURIDINE; UNCLASSIFIED DRUG; URACIL; URIDINE; URIDINE PHOSPHORYLASE;

EID: 0034101695     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800051002     Document Type: Article
Times cited : (18)

References (81)
  • 1
    • 0030000144 scopus 로고    scopus 로고
    • 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor and 2′,3′,5′-tri-o-acetyluridine, a pro-drug of uridine as modulators of plasma uridine concentration: Implication for chemotherapy
    • 1. Ashour OM, Naguib FNM, el Kouni MH (1996) 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor and 2′,3′,5′-tri-o-acetyluridine, a pro-drug of uridine as modulators of plasma uridine concentration: implication for chemotherapy. Biochem Pharmacol 51: 1601
    • (1996) Biochem Pharmacol , vol.51 , pp. 1601
    • Ashour, O.M.1    Naguib, F.N.M.2    El Kouni, M.H.3
  • 2
    • 0020541484 scopus 로고
    • Effect of uridine supply on glycogen resynthesis after ischaemia in the isolated perfused rat heart
    • 2. Aussedat J (1983) Effect of uridine supply on glycogen resynthesis after ischaemia in the isolated perfused rat heart. Cardiovasc Res 17: 145
    • (1983) Cardiovasc Res , vol.17 , pp. 145
    • Aussedat, J.1
  • 3
    • 0001040602 scopus 로고
    • Uridine incorporation in normal and ischaemic perfused rat heart
    • 3. Aussedat J (1984) Uridine incorporation in normal and ischaemic perfused rat heart. Mol Physiol 6: 247
    • (1984) Mol Physiol , vol.6 , pp. 247
    • Aussedat, J.1
  • 4
    • 0020350153 scopus 로고
    • Nucleotides uridyliques et glycogene cardiaque: Effect de l'administration d'uridine et de ribose chez le rat
    • 4. Aussedat J, Verdetti J, Grably S, Rossi A (1982) Nucleotides uridyliques et glycogene cardiaque: effect de l'administration d'uridine et de ribose chez le rat. J Physiol (Paris) 78: 331
    • (1982) J Physiol (Paris) , vol.78 , pp. 331
    • Aussedat, J.1    Verdetti, J.2    Grably, S.3    Rossi, A.4
  • 5
    • 0001357633 scopus 로고
    • Analisi dell'azione di nucleosidi pirimidinici sull'elettroencefallogramma umano attivato con megimide
    • 5. Bonavita B, Zito M (1968) Analisi dell'azione di nucleosidi pirimidinici sull'elettroencefallogramma umano attivato con megimide. Riv Neurol 38: 317
    • (1968) Riv Neurol , vol.38 , pp. 317
    • Bonavita, B.1    Zito, M.2
  • 6
    • 0000838207 scopus 로고
    • Analisi degli effetti centrali di nucleotidi purinici e pirinmidinici e loro derivati III
    • 6. Bonavita V, Monaco P, Tripi E (1964) Analisi degli effetti centrali di nucleotidi purinici e pirinmidinici e loro derivati III. Esperimenti farmacologici. Acta Neurol (Napoli) 19: 215
    • (1964) Esperimenti Farmacologici. Acta Neurol (Napoli) , vol.19 , pp. 215
    • Bonavita, V.1    Monaco, P.2    Tripi, E.3
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248
    • (1976) Anal Biochem , vol.72 , pp. 248
    • Bradford, M.M.1
  • 8
    • 0000927807 scopus 로고
    • Effects of nucleosides on acute left ventricular failure in isolated dog heart
    • 8. Buckley NM, Tsuboi KK, Zeic NJ (1959) Effects of nucleosides on acute left ventricular failure in isolated dog heart. Circ Res 7: 847
    • (1959) Circ Res , vol.7 , pp. 847
    • Buckley, N.M.1    Tsuboi, K.K.2    Zeic, N.J.3
  • 9
    • 0018722722 scopus 로고
    • Effects of cytidine and uridine on the regeneration of the liver in rats poisoned with carbon tetrachloride
    • 9. Bushma MI, Parkhovchenko EI, Peschanskii VS (1980) Effects of cytidine and uridine on the regeneration of the liver in rats poisoned with carbon tetrachloride. Bull Exp Biol Med 88: 722
    • (1980) Bull Exp Biol Med , vol.88 , pp. 722
    • Bushma, M.I.1    Parkhovchenko, E.I.2    Peschanskii, V.S.3
  • 13
    • 0022379204 scopus 로고
    • Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine
    • 13. Darnowski JW, Handschumacher RE (1985) Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine. Cancer Res 45: 5364
    • (1985) Cancer Res , vol.45 , pp. 5364
    • Darnowski, J.W.1    Handschumacher, R.E.2
  • 14
    • 0022638354 scopus 로고
    • Tissue uridine pools: Evidence in vivo of a concentrative mechanism for uridine uptake
    • 14. Darnowski JW, Handschumacher RE (1986) Tissue uridine pools: evidence in vivo of a concentrative mechanism for uridine uptake. Cancer Res 46: 3490
    • (1986) Cancer Res , vol.46 , pp. 3490
    • Darnowski, J.W.1    Handschumacher, R.E.2
  • 15
    • 0023942798 scopus 로고
    • Benzylacyclouridine: Pharmacokinetics, metabolism and biochemical effects in mice
    • 15. Darnowski JW, Handschumacher RE (1988) Benzylacyclouridine: pharmacokinetics, metabolism and biochemical effects in mice. Biochem Pharmacol 37: 2613
    • (1988) Biochem Pharmacol , vol.37 , pp. 2613
    • Darnowski, J.W.1    Handschumacher, R.E.2
  • 16
    • 0024550927 scopus 로고
    • Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools
    • 16. Darnowski JW, Handschumacher RE (1989) Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools. Pharmacol Ther 41: 381
    • (1989) Pharmacol Ther , vol.41 , pp. 381
    • Darnowski, J.W.1    Handschumacher, R.E.2
  • 17
    • 0025854707 scopus 로고
    • Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine
    • 17. Darnowski JW, Handschumacher RE, Wiegand RA, Goulette FA, Calabresi P (1991) Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine. Biochem Pharmacol 41: 2031
    • (1991) Biochem Pharmacol , vol.41 , pp. 2031
    • Darnowski, J.W.1    Handschumacher, R.E.2    Wiegand, R.A.3    Goulette, F.A.4    Calabresi, P.5
  • 18
    • 0027505817 scopus 로고
    • Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine
    • 18. Davis ST, Joyner SS, Chandrasurin P, Baccanari DP (1993) Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine. Biochem Pharmacol 45: 173
    • (1993) Biochem Pharmacol , vol.45 , pp. 173
    • Davis, S.T.1    Joyner, S.S.2    Chandrasurin, P.3    Baccanari, D.P.4
  • 19
    • 0016605672 scopus 로고
    • Anticonvulsant activities of δ-8 and δ-9 tetrahydrocannabinol and uridine
    • 19. Dwivedi C, Harbison RD (1975) Anticonvulsant activities of Δ-8 and Δ-9 tetrahydrocannabinol and uridine. Toxicol Appl Pharmacol 31: 452
    • (1975) Toxicol Appl Pharmacol , vol.31 , pp. 452
    • Dwivedi, C.1    Harbison, R.D.2
  • 21
    • 0027306127 scopus 로고
    • Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: Implications for chemotherapy with 5-fluoropyrimidines
    • 21. el Kouni MH, el Kouni MM, Naguib FNM (1993) Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines. Cancer Res 53: 3687
    • (1993) Cancer Res , vol.53 , pp. 3687
    • El Kouni, M.H.1    El Kouni, M.M.2    Naguib, F.N.M.3
  • 22
    • 0002387937 scopus 로고
    • Influence of certain nucleosides on glucose metabolism in man
    • 22. Elrick H, Hlad CJ Jr, Arai Y (1962) Influence of certain nucleosides on glucose metabolism in man. Metabolism 11: 46
    • (1962) Metabolism , vol.11 , pp. 46
    • Elrick, H.1    Hlad C.J., Jr.2    Arai, Y.3
  • 23
    • 0025198422 scopus 로고
    • Differential effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice
    • 23. Falcone A, Darnowski JW, Ruprecht RM, Chu SH, Burnetti I, Calabresi P (1990) Differential effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice. Blood 76: 2216
    • (1990) Blood , vol.76 , pp. 2216
    • Falcone, A.1    Darnowski, J.W.2    Ruprecht, R.M.3    Chu, S.H.4    Burnetti, I.5    Calabresi, P.6
  • 24
    • 0026772623 scopus 로고
    • Effects of uridine in the treatment of diabetic neuropathy: An electrophysiological study
    • 24. Gallai V, Mazzotta G, Montesi S, Sarchielli P, Del Gatto F (1992) Effects of uridine in the treatment of diabetic neuropathy: an electrophysiological study. Acta Neurol Scand 86: 3
    • (1992) Acta Neurol Scand , vol.86 , pp. 3
    • Gallai, V.1    Mazzotta, G.2    Montesi, S.3    Sarchielli, P.4    Del Gatto, F.5
  • 25
    • 0019519002 scopus 로고
    • Novel single-pass exchange of circulating uridine in rat liver
    • 25. Gasser T, Moyer JD, Handschumacher RE (1981) Novel single-pass exchange of circulating uridine in rat liver. Science 213: 777
    • (1981) Science , vol.213 , pp. 777
    • Gasser, T.1    Moyer, J.D.2    Handschumacher, R.E.3
  • 26
    • 0002204958 scopus 로고
    • Cytidine and uridine requirement of the brain
    • 26. Geiger A, Yamasaki S (1956) Cytidine and uridine requirement of the brain. J Neurochem 1: 93
    • (1956) J Neurochem , vol.1 , pp. 93
    • Geiger, A.1    Yamasaki, S.2
  • 27
    • 0018077177 scopus 로고
    • Interactive graphic package for pharmacokinetic analysis
    • 27. Gomeni R, Gomeni C (1978) Interactive graphic package for pharmacokinetic analysis. Com Biomed Res 11: 345
    • (1978) Com Biomed Res , vol.11 , pp. 345
    • Gomeni, R.1    Gomeni, C.2
  • 28
    • 0027725171 scopus 로고
    • Phenylselenenyl-and phenylthio-substituted pyrimidines as potential inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase
    • 28. Goudgaon NM, Naguib FNM, el Kouni MH, Schinazi RF (1993) Phenylselenenyl-and phenylthio-substituted pyrimidines as potential inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase. J Med Chem 36: 4250
    • (1993) J Med Chem , vol.36 , pp. 4250
    • Goudgaon, N.M.1    Naguib, F.N.M.2    El Kouni, M.H.3    Schinazi, R.F.4
  • 29
    • 0029050136 scopus 로고
    • Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent, leflunomide
    • 29. Greene S, Watanabe K, Braatz-Trulson J, Lou L (1995) Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent, leflunomide. Biochem Pharmacol 50: 861
    • (1995) Biochem Pharmacol , vol.50 , pp. 861
    • Greene, S.1    Watanabe, K.2    Braatz-Trulson, J.3    Lou, L.4
  • 30
    • 0002685062 scopus 로고
    • Fluorinated pyrimidines
    • Chabner BA, Collins JM (eds). Lippincott, Philadelphia
    • 30. Grem JL (1990) Fluorinated pyrimidines. In: Chabner BA, Collins JM (eds) Cancer chemotherapy; principles and practice. Lippincott, Philadelphia, p 180
    • (1990) Cancer Chemotherapy; Principles and Practice , pp. 180
    • Grem, J.L.1
  • 31
    • 0021045267 scopus 로고
    • Interaction of uridine with GABA binding sites in cerebellar membranes of the rat
    • 31. Guarneri P, Guarner R, Mocciaro C, Piccoli F (1983) Interaction of uridine with GABA binding sites in cerebellar membranes of the rat. Neurochem Res 8: 1537
    • (1983) Neurochem Res , vol.8 , pp. 1537
    • Guarneri, P.1    Guarner, R.2    Mocciaro, C.3    Piccoli, F.4
  • 32
    • 0022339360 scopus 로고
    • Interaction of uridine with gaba-mediated inhibitory transmission: Studies in vivo and in vitro
    • 32. Guarneri P, Guarner R, Mocciaro C, Piccoli F (1985) Interaction of uridine with GABA-mediated inhibitory transmission: studies in vivo and in vitro. Epilepsia 26: 666
    • (1985) Epilepsia , vol.26 , pp. 666
    • Guarneri, P.1    Guarner, R.2    Mocciaro, C.3    Piccoli, F.4
  • 33
    • 0021869359 scopus 로고
    • Uridine catabolism in Kupffer cells, endothelial cells, and hepatocytes
    • 33. Holstege A, Leser, H-G, Pausch J, Gerok W (1985) Uridine catabolism in Kupffer cells, endothelial cells, and hepatocytes, Eur J Biochem 149: 169
    • (1985) Eur J Biochem , vol.149 , pp. 169
    • Holstege, A.1    Leser, H.-G.2    Pausch, J.3    Gerok, W.4
  • 34
    • 0023030918 scopus 로고
    • Effect of 5-diazouracil on the catabolism of circulating pyrimidines in rat liver and kidneys
    • 34. Holstege A, Pausch J, Gerok W (1986) Effect of 5-diazouracil on the catabolism of circulating pyrimidines in rat liver and kidneys. Cancer Res 46: 5576
    • (1986) Cancer Res , vol.46 , pp. 5576
    • Holstege, A.1    Pausch, J.2    Gerok, W.3
  • 35
    • 0000119740 scopus 로고
    • Sleep-Promoting Substance (SPS) and physiological sleep regulation
    • 35. Inoué S (1993) Sleep-promoting substance (SPS) and physiological sleep regulation. Zool Sci 10: 557
    • (1993) Zool Sci , vol.10 , pp. 557
    • Inoué, S.1
  • 36
    • 0014691717 scopus 로고
    • Azione della citidina ed uridina nel trattamento delle indromi neuropsichiche da encefalopatie di varia origine
    • 36. Jann G, Delzanno GB (1969) Azione della citidina ed uridina nel trattamento delle indromi neuropsichiche da encefalopatie di varia origine. Minerva Med 60: 2092
    • (1969) Minerva Med , vol.60 , pp. 2092
    • Jann, G.1    Delzanno, G.B.2
  • 37
    • 0027504790 scopus 로고
    • Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: Prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model by uridine and pyruvate
    • 37. Keilbauch SA, Hobbs GA, Simpson MV (1993) Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model by uridine and pyruvate. Mol Pharmacol 44: 702
    • (1993) Mol Pharmacol , vol.44 , pp. 702
    • Keilbauch, S.A.1    Hobbs, G.A.2    Simpson, M.V.3
  • 38
    • 0002581510 scopus 로고
    • Hereditary orotic aciduria
    • Stanbury JB, Wyngaarden JB, Fredrickson DS (eds). McGraw-Hill, New York
    • 38. Kelly WN, Smith LH Jr (1978) Hereditary orotic aciduria. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The metabolic basis of inherited disease, 4th edn. McGraw-Hill, New York, p 1045
    • (1978) The Metabolic Basis of Inherited Disease, 4th Edn. , pp. 1045
    • Kelly, W.N.1    Smith L.H., Jr.2
  • 39
    • 0020607823 scopus 로고
    • Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil
    • 39. Klubes P, Cerna I (1983) Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil. Cancer Res 43: 3182
    • (1983) Cancer Res , vol.43 , pp. 3182
    • Klubes, P.1    Cerna, I.2
  • 40
    • 0020033260 scopus 로고
    • Uridine rescue from the lethal toxicity of 5-fluorouracil in mice
    • 40. Klubes P, Cerna I, Meldon MA (1982) Uridine rescue from the lethal toxicity of 5-fluorouracil in mice. Cancer Chemother Pharmacol 8: 17
    • (1982) Cancer Chemother Pharmacol , vol.8 , pp. 17
    • Klubes, P.1    Cerna, I.2    Meldon, M.A.3
  • 41
    • 0022494275 scopus 로고
    • Comparison of the bioavailability of uridine in mice after either oral or parenteral administration
    • 41. Klubes P, Geffen DB, Cysyk RL (1986) Comparison of the bioavailability of uridine in mice after either oral or parenteral administration. Cancer Chemother Pharmacol 17: 236
    • (1986) Cancer Chemother Pharmacol , vol.17 , pp. 236
    • Klubes, P.1    Geffen, D.B.2    Cysyk, R.L.3
  • 42
    • 0017056538 scopus 로고
    • Effects of uridine and inosine on glucose metabolism in skeletal muscle and activated lipolysis in adipose tissue
    • 42. Kypson J, Hait G (1976) Effects of uridine and inosine on glucose metabolism in skeletal muscle and activated lipolysis in adipose tissue. J Pharmacol Exp Ther 199: 565
    • (1976) J Pharmacol Exp Ther , vol.199 , pp. 565
    • Kypson, J.1    Hait, G.2
  • 43
    • 0017739825 scopus 로고
    • Metabolic effects of inosine and uridine in rabbit hearts and rat skeletal muscles
    • 43. Kypson J, Hait G (1977) Metabolic effects of inosine and uridine in rabbit hearts and rat skeletal muscles. Biochem Pharmacol 26: 1585
    • (1977) Biochem Pharmacol , vol.26 , pp. 1585
    • Kypson, J.1    Hait, G.2
  • 44
    • 0018097297 scopus 로고
    • Effects of uridine on the performance and the metabolism of oxygenated and hypoxic rabbit hearts
    • 44. Kypson J, Hait G, Mathew R (1978) Effects of uridine on the performance and the metabolism of oxygenated and hypoxic rabbit hearts. J Mol Cell Cardiol 10: 545
    • (1978) J Mol Cell Cardiol , vol.10 , pp. 545
    • Kypson, J.1    Hait, G.2    Mathew, R.3
  • 45
    • 0021689688 scopus 로고
    • Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity
    • 45. Leyva A, van Groeningen CJ, Kraal I, Peters GJ, Lankelma J, Pinedo HM (1984) Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity. Cancer Res 44: 5928
    • (1984) Cancer Res , vol.44 , pp. 5928
    • Leyva, A.1    Van Groeningen, C.J.2    Kraal, I.3    Peters, G.J.4    Lankelma, J.5    Pinedo, H.M.6
  • 46
    • 0000169232 scopus 로고
    • An algorithm for least squares estimation of nonlinear parameters
    • 46. Marquardt DW (1963) An algorithm for least squares estimation of nonlinear parameters. J Soc Ind Appl Math 11: 431
    • (1963) J Soc Ind Appl Math , vol.11 , pp. 431
    • Marquardt, D.W.1
  • 48
    • 0024375273 scopus 로고
    • Use of oral uridine as a substitute for parental uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine
    • 48. Martin DS, Stolfi RL, Sawyer RC (1989) Use of oral uridine as a substitute for parental uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine. Cancer Chemother Pharmacol 24: 9
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 9
    • Martin, D.S.1    Stolfi, R.L.2    Sawyer, R.C.3
  • 49
    • 0002404463 scopus 로고
    • The use of glucose and uridine to control contractility and extensibility disturbances in the nonischemized compartments of the heart in myocardial infarction
    • 49. Meerson FZ, Dosmagabetova RS (1985) The use of glucose and uridine to control contractility and extensibility disturbances in the nonischemized compartments of the heart in myocardial infarction. Kardiologiya 25: 91
    • (1985) Kardiologiya , vol.25 , pp. 91
    • Meerson, F.Z.1    Dosmagabetova, R.S.2
  • 50
    • 4243551491 scopus 로고
    • Uridine regulation by the isolated rat liver: Perfusion with an artificial oxygen carrier
    • 50. Monks A, Cysyk RL (1982) Uridine regulation by the isolated rat liver: perfusion with an artificial oxygen carrier. Am J Physiol 242: R465
    • (1982) Am J Physiol , vol.242
    • Monks, A.1    Cysyk, R.L.2
  • 51
    • 0020531847 scopus 로고
    • Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver
    • 51. Monks A, Ayers O, Cysyk RL (1983) Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver. Biochem Pharmacol 32: 2003
    • (1983) Biochem Pharmacol , vol.32 , pp. 2003
    • Monks, A.1    Ayers, O.2    Cysyk, R.L.3
  • 52
    • 0014022388 scopus 로고
    • Sull'impiego terapeutico dei nucleosidi citidina ed uridina in alcune affezioni neurologiche
    • 52. Monticone GF, Bergamasco B, Congnazzo A (1966) Sull'impiego terapeutico dei nucleosidi citidina ed uridina in alcune affezioni neurologiche. Minerva Med 57: 4348
    • (1966) Minerva Med , vol.57 , pp. 4348
    • Monticone, G.F.1    Bergamasco, B.2    Congnazzo, A.3
  • 53
    • 0019483866 scopus 로고
    • Salvage of circulating pyrimidine nucleosides in the rat
    • 53. Moyer JD, Oliver JT, Handschumacher RE (1981) Salvage of circulating pyrimidine nucleosides in the rat. Cancer Res 41: 3010
    • (1981) Cancer Res , vol.41 , pp. 3010
    • Moyer, J.D.1    Oliver, J.T.2    Handschumacher, R.E.3
  • 55
    • 0028238060 scopus 로고
    • Uridine potentiates haloperidol's disruption of conditioned avoidance responding
    • 55. Myers CS, Fisher H, Wagner GC (1994) Uridine potentiates haloperidol's disruption of conditioned avoidance responding. Brain Res 651: 194
    • (1994) Brain Res , vol.651 , pp. 194
    • Myers, C.S.1    Fisher, H.2    Wagner, G.C.3
  • 56
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • 56. Naguib FNM, el Kouni MH, Cha S (1985) Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45: 5405
    • (1985) Cancer Res , vol.45 , pp. 5405
    • Naguib, F.N.M.1    El Kouni, M.H.2    Cha, S.3
  • 57
    • 0023277204 scopus 로고
    • New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers
    • 57. Naguib FNM, el Kouni MH, Chu SH, Cha S (1987) New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers. Biochem Pharmacol 36: 2195
    • (1987) Biochem Pharmacol , vol.36 , pp. 2195
    • Naguib, F.N.M.1    El Kouni, M.H.2    Chu, S.H.3    Cha, S.4
  • 58
    • 0027392924 scopus 로고
    • Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver: Possible relevance to chemotherapy with 5-fluoropyrimidines
    • 58. Naguib FNM, Soong S-J, el Kouni MH (1993) Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver: possible relevance to chemotherapy with 5-fluoropyrimidines. Biochem Pharmacol 45: 667
    • (1993) Biochem Pharmacol , vol.45 , pp. 667
    • Naguib, F.N.M.1    Soong, S.-J.2    El Kouni, M.H.3
  • 59
    • 0029618768 scopus 로고
    • Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine
    • 59. Nair RV, Cao W, Morris RE (1995) Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunol Lett 48: 77
    • (1995) Immunol Lett , vol.48 , pp. 77
    • Nair, R.V.1    Cao, W.2    Morris, R.E.3
  • 60
    • 0020037313 scopus 로고
    • 5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase
    • 60. Niedzwicki JG, Chu SH, el Kouni MH, Rowe EC, Cha S (1982) 5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase. Biochem Pharmacol 31: 1857
    • (1982) Biochem Pharmacol , vol.31 , pp. 1857
    • Niedzwicki, J.G.1    Chu, S.H.2    El Kouni, M.H.3    Rowe, E.C.4    Cha, S.5
  • 61
    • 0030881884 scopus 로고    scopus 로고
    • Developmental disorder associated with increased cellular nucleotidase activity
    • 61. Page T, Yu A, Fontanesi J, Nyhan WL (1997) Developmental disorder associated with increased cellular nucleotidase activity. Proc Natl Acad Sci USA 94: 11601
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11601
    • Page, T.1    Yu, A.2    Fontanesi, J.3    Nyhan, W.L.4
  • 62
    • 0025815823 scopus 로고
    • Clinical relevance of biochemical modulation of 5-fluorouracil
    • 62. Peters GJ, van Groeningen CJ (1991) Clinical relevance of biochemical modulation of 5-fluorouracil. Ann Oncol 2: 469
    • (1991) Ann Oncol , vol.2 , pp. 469
    • Peters, G.J.1    Van Groeningen, C.J.2
  • 64
    • 0023626609 scopus 로고
    • Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites
    • 64. Peters GJ, van Groeningen CJ, Laurensse E, Levya A, Pinedo HM (1987b) Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. Cancer Chemother Pharmacol 20: 101
    • (1987) Cancer Chemother Pharmacol , vol.20 , pp. 101
    • Peters, G.J.1    Van Groeningen, C.J.2    Laurensse, E.3    Levya, A.4    Pinedo, H.M.5
  • 67
    • 0015797746 scopus 로고
    • Anticonvulsant effects of uridine: Comparative analysis of metrazol and penicillin induced foci
    • 67. Roberts CA (1973) Anticonvulsant effects of uridine: comparative analysis of Metrazol and penicillin induced foci. Brain Res 55: 291
    • (1973) Brain Res , vol.55 , pp. 291
    • Roberts, C.A.1
  • 68
    • 0016340759 scopus 로고
    • Uridine anticonvulsant effects: Selective control of nucleoside incorporation in experimental epilepsy
    • 68. Roberts CA, Kreisman NR, Waltman M (1974) Uridine anticonvulsant effects: selective control of nucleoside incorporation in experimental epilepsy. Epilepsia 15: 479
    • (1974) Epilepsia , vol.15 , pp. 479
    • Roberts, C.A.1    Kreisman, N.R.2    Waltman, M.3
  • 69
    • 0013842520 scopus 로고
    • L'impiego di alcuni nucleosidi non vasoattivi (citidina e uridina) nella terapia delle vasculopatie cerebrali
    • 69. Sanguineti I, Zerbi D (1965) L'impiego di alcuni nucleosidi non vasoattivi (citidina e uridina) nella terapia delle vasculopatie cerebrali. Minerva Med 56: 3352
    • (1965) Minerva Med , vol.56 , pp. 3352
    • Sanguineti, I.1    Zerbi, D.2
  • 70
    • 0027478929 scopus 로고
    • Uridine allows dose escalation of 5-fluorouracil when given with N-phosphoancetyl-l-aspartate, methotrexate, and leucovorin
    • 70. Seiter K, Kemeny N, Martin D, Schneider A, Williams L, Colofiore J, Sawyer R (1993) Uridine allows dose escalation of 5-fluorouracil when given with N-phosphoancetyl-l-aspartate, methotrexate, and leucovorin. Cancer 71: 1875
    • (1993) Cancer , vol.71 , pp. 1875
    • Seiter, K.1    Kemeny, N.2    Martin, D.3    Schneider, A.4    Williams, L.5    Colofiore, J.6    Sawyer, R.7
  • 71
    • 0014959007 scopus 로고
    • Efficacia dell'assoiazione citidina-uridina nelle affezioni vascolari dell'encefalo
    • 71. Sepe O (1970) Efficacia dell'assoiazione citidina-uridina nelle affezioni vascolari dell'encefalo. Minerva Med 61: 5934
    • (1970) Minerva Med , vol.61 , pp. 5934
    • Sepe, O.1
  • 72
    • 0023788972 scopus 로고
    • Uridine reverses the toxicity of 3′-azido-3′-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity
    • 72. Sommadossi J-P, Carlisle R, Schinazi RF, Zhou Z (1988) Uridine reverses the toxicity of 3′-azido-3′-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. Antimicrob Agents Chemother 32: 997
    • (1988) Antimicrob Agents Chemother , vol.32 , pp. 997
    • Sommadossi, J.-P.1    Carlisle, R.2    Schinazi, R.F.3    Zhou, Z.4
  • 73
    • 0003162547 scopus 로고
    • Novel pharmacologie approaches for the treatment of AIDS and potential use of uridine phosphorylase inhibitors
    • Diasio RB, Sommadossi J-P (eds). Pergamon Press, New York
    • 73. Sommadossi J-P, Zhu Z, Carlisle R, Xie MY, Weidner DA, el Kouni MH (1990) Novel pharmacologie approaches for the treatment of AIDS and potential use of uridine phosphorylase inhibitors In: Diasio RB, Sommadossi J-P (eds) Advances in chemotherapy of AIDS. Pergamon Press, New York, p 63
    • (1990) Advances in Chemotherapy of Aids , pp. 63
    • Sommadossi, J.-P.1    Zhu, Z.2    Carlisle, R.3    Xie, M.Y.4    Weidner, D.A.5    El Kouni, M.H.6
  • 74
    • 0028849905 scopus 로고
    • Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: Implications for chemotherapy
    • 74. Sommadossi J-P, Cretton EM, Kidd LB, McClure HM, Anderson DC, el Kouni MH (1995) Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy. Cancer Chemother Pharmacol 37: 14
    • (1995) Cancer Chemother Pharmacol , vol.37 , pp. 14
    • Sommadossi, J.-P.1    Cretton, E.M.2    Kidd, L.B.3    McClure, H.M.4    Anderson, D.C.5    El Kouni, M.H.6
  • 75
    • 0019522953 scopus 로고
    • The relationship between uracil nucleotide concentrations and glycogen synthesis in hepatocytes from fed and fasted rats
    • 75. Songu E, Haugaard ES, Wildley G, Haugaard N (1980) The relationship between uracil nucleotide concentrations and glycogen synthesis in hepatocytes from fed and fasted rats. Metabolism 30: 119
    • (1980) Metabolism , vol.30 , pp. 119
    • Songu, E.1    Haugaard, E.S.2    Wildley, G.3    Haugaard, N.4
  • 76
    • 0027182004 scopus 로고
    • Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells
    • 76. Tamura K, Woo J, Bakri MT, Thomson AW (1993) Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells. Immunology 79: 587
    • (1993) Immunology , vol.79 , pp. 587
    • Tamura, K.1    Woo, J.2    Bakri, M.T.3    Thomson, A.W.4
  • 77
    • 0022457607 scopus 로고
    • Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity
    • 77. van Groeningen CJ, Leyva A, Kraal I, Peters GJ, Pinedo HM (1986) Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity. Cancer Treat Rep 70: 745
    • (1986) Cancer Treat Rep , vol.70 , pp. 745
    • Van Groeningen, C.J.1    Leyva, A.2    Kraal, I.3    Peters, G.J.4    Pinedo, H.M.5
  • 78
    • 0024578398 scopus 로고
    • Reversal of 5-fluorouracil induced myelosuppression by prolonged administration of high-dose uridine
    • 78. van Groeningen CJ, Peters GJ, Leyva A, Laurensse E, Pinedo HM (1989) Reversal of 5-fluorouracil induced myelosuppression by prolonged administration of high-dose uridine. J Natl Cancer Inst 81: 157
    • (1989) J Natl Cancer Inst , vol.81 , pp. 157
    • Van Groeningen, C.J.1    Peters, G.J.2    Leyva, A.3    Laurensse, E.4    Pinedo, H.M.5


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