A forward genetic approach for analyzing the mechanism of resistance to the Anti-Cancer Drug, 5-Fluorouracil, using Caenorhabditis elegans

Molecules and Cells

Volumn 25, Issue 1, 2008, Pages 119-123

  Kim, Seongseop ^a   Shim, Jaegal ^a  

^a National Cancer Center   (South Korea)

Author keywords

5 Fluorouracil; Anti cancer drug; C. elegans; Mutant screen; Resistance

Indexed keywords

FLUOROURACIL;

ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CANCER RESISTANCE; CELL DEATH; CHROMOSOME MAP; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; GENETIC ANALYSIS; GERM CELL; NONHUMAN;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CAENORHABDITIS ELEGANS; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENETIC COMPLEMENTATION TEST; GERM CELLS; HUMANS; LINKAGE (GENETICS); NEOPLASMS;

CAENORHABDITIS ELEGANS;

EID: 42949105481     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bean, B. and Tomasz, A. (1971). Inhibitory effects and metabolism of 5-fluoropyrimidine derivatives in pneumococcus. J. Bacteriol. 106, 412-420.
2. Beck, C.F., Ingraham, J.L., Neuhard, J., and Thomassen, E. (1972). Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium. J. Bacteriol. 110, 219-228.
3. Bienner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
4. Clynes, M.M. and Duke, E.J. (1976)., Altered pyrimidine-salvage metabolism in a 5-fluorouracil-resistant mutant of Drosophila melanogaster. Biochem. Soc. Trans. 4, 900-901.
5. Davis, M.W., Hammarlund, M., Harrach, T., Hullett, P., Olsen, S., and Jorgensen, E.M. (2005). Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics 6, 118.
6. Derry, W.B., Putzke, A.P., and Rothman, J.H. (2001). Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294, 591-595.
7. Duke, E.J. and Glassman, E. (1968). Drug effects in Drosophila: streptomycin sensitive strains and fluorouracil resistant strains. Nature 220, 588-589.
8. Hengartner, M.O. (1999). Programmed cell death in the nematode C. elegans. Recent progress in hormone research 54, 213-222; discussion 222-214.
9. Jund, R. and Lacroute, F. (1970). Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae. J. Bacteriol. 102, 607-615.
10. Kern, L., de Montigny, J., Jund, R., and Lacroute, F. (1990). The FUR1 gene of Saccharomyces cerevisiae: cloning, structure and expression of wild-type and mutant alleles.. Gene 88, 149-157.
11. Liu, Q.A. and Hengartner, M.O. (1999). The molecular mechanism of programmed cell death in C. elegans. Ann. N Y Acad. Sci. 887, 92-104.
12. Longley, D.B., Harkin, D.P., and Johnston, P.G. (2003). 5-fluorouracil: Mechanisms of action and clinical strategies. Nature reviews 3, 330-338.
13. Longley, D.B. and Johnston, P.G. (2005). Molecular mechanisms of drug resistance. J. Pathol. 205, 275-292.
14. Maring, J.G., Groen, H.J., Wachters, F.M., Uges, D.R., and de Vries, E.G (2005). Genetic factors influencing pyrimidine-antagonist chemotherapy. The pharmacogenomics j. 5, 226-243.
15. Peters, G.J., Backus, A.H., Freemantle, S., van Triest,,B., Codacci-Pisanelli, G, van der Wilt, C.L., Smid, K., Lunec, J., Calvert, A.H., Marsh, S., et al.. (2002). Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim. Biophys. Acta 1587, 194-205.
16. Pratt, S., Shepard, R.L., Kandasamy, R.A., Johnston, P.A., Perry, W., 3rd, and Dantzig, A.H. (2005). The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol. Cancer Ther. 4, 855-863.
17. Rich, T.A., Shepard, R.C., and Mosley, S.T. (2004). Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy. J.. Clin. Oncol. 22, 2214-2232.
18. Schumacher, B., Hofmann, K., Boulton, S., and Gartner, A. (2001). The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr. Biol. 11, 1722-1727.
19. Wicks, S.R., Yeh, R.T., Gish, W.R., Waterston, R.H., and Plasterk, R-H. (2001). Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat. Genet. 28, 160-164.
20. Yoo, B.C., Jeon, E., Hong, S.H., Shin, Y.K., Chang, H.J., and Park, J.G. (2004). Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. Clin. Cancer Res. 10, 4176-4184.