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Volumn 48, Issue 2, 2001, Pages 93-98

Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer

Author keywords

5 FU sensitivity; Colorectal cancer; Dihydropyrimidine dehydrogenase; Thymidylate synthase

Indexed keywords

5 ETHYNYLURACIL; ANTINEOPLASTIC AGENT; CARBON 14; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; MESSENGER RNA; RALTITREXED; THYMIDYLATE SYNTHASE;

EID: 0034859473     PISSN: 00235679     EISSN: None     Source Type: Journal    
DOI: 10.2739/kurumemedj.48.93     Document Type: Article
Times cited : (13)

References (32)
  • 1
    • 33745464490 scopus 로고
    • Fluorinated pyrimidines: A new class of tumor-inhibitory compounds
    • Heiderberger C, Chaudhuri NK, and Duschinsky R. Fluorinated pyrimidines: a new class of tumor-inhibitory compounds. Naturel957; 179:663-666.
    • (1957) Nature , vol.179 , pp. 663-666
    • Heiderberger, C.1    Chaudhuri, N.K.2    Duschinsky, R.3
  • 2
    • 0025773311 scopus 로고
    • A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas
    • Johnson PWM, Thompson PI, Seymour MT, Deasy NP, Thuraisingham RC et al. A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas. Br J Cancer 1991; 64:603-605.
    • (1991) Br J Cancer , vol.64 , pp. 603-605
    • Johnson, P.W.M.1    Thompson, P.I.2    Seymour, M.T.3    Deasy, N.P.4    Thuraisingham, R.C.5
  • 3
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio RB, and Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokin 1989; 16:215-237.
    • (1989) Clin Pharmacokin , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 4
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-fluouracil
    • Parker WB, and Cheng YC. Metabolism and mechanism of action of 5-fluouracil. Pharm Ther 1990; 48:381-395.
    • (1990) Pharm Ther , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 5
    • 0017716458 scopus 로고
    • Thymidylate synthetase a target enzyme in cancer chemo-therapy
    • Danenberg PV. Thymidylate synthetase a target enzyme in cancer chemo-therapy. Biochem Biophys Acta 1977; 473:73-92.
    • (1977) Biochem Biophys Acta , vol.473 , pp. 73-92
    • Danenberg, P.V.1
  • 6
    • 0000875305 scopus 로고
    • Studies on fluorinated pyrimidines, VDI. Inhibition of thymidylate synthase
    • Hartman KY, and Heidelberger C. Studies on fluorinated pyrimidines, VDI. Inhibition of thymidylate synthase. J Biol Chem 1961; 236:3006-3018.
    • (1961) J Biol Chem , vol.236 , pp. 3006-3018
    • Hartman, K.Y.1    Heidelberger, C.2
  • 8
    • 0020056302 scopus 로고
    • In vivo kinetics of thymidylate synthetase inhibition in 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas
    • Spears CD, Shahinian AH, Moran RG, Heidelberger C, and Corbett TH. In vivo kinetics of thymidylate synthetase inhibition in 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas. Cancer Res 1982; 43:450-456.
    • (1982) Cancer Res , vol.43 , pp. 450-456
    • Spears, C.D.1    Shahinian, A.H.2    Moran, R.G.3    Heidelberger, C.4    Corbett, T.H.5
  • 9
    • 0023753618 scopus 로고
    • Mechanism of innate resistance to thymidylate synthase inhibition after 5-fluorouracil
    • Spears CD, Gustavsson BG, Berne M, Frosing R, Bernstein L et al. Mechanism of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Cancer Res 1988; 48:5894-5900.
    • (1988) Cancer Res , vol.48 , pp. 5894-5900
    • Spears, C.D.1    Gustavsson, B.G.2    Berne, M.3    Frosing, R.4    Bernstein, L.5
  • 10
    • 0028151449 scopus 로고
    • The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
    • Johnston PG, Fisher ER, Rockette HE, Fisher B, Wolmark N et al. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 1994; 12:2640-2647.
    • (1994) J Clin Oncol , vol.12 , pp. 2640-2647
    • Johnston, P.G.1    Fisher, E.R.2    Rockette, H.E.3    Fisher, B.4    Wolmark, N.5
  • 11
    • 0028019880 scopus 로고
    • Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Complications for treatment with fluorouracil
    • Peters GJ, van der Wolt CL, Groeningen CJ, Smid K, Meijer S et al. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: complications for treatment with fluorouracil. J Clin Oncol 1994; 12:2035-2042.
    • (1994) J Clin Oncol , vol.12 , pp. 2035-2042
    • Peters, G.J.1    Van Der Wolt, C.L.2    Groeningen, C.J.3    Smid, K.4    Meijer, S.5
  • 12
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995; 55:1407-1412.
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5
  • 13
    • 9044250848 scopus 로고    scopus 로고
    • Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival
    • Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S et al. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol 1996; 4:176-182.
    • (1996) J Clin Oncol , vol.4 , pp. 176-182
    • Lenz, H.J.1    Leichman, C.G.2    Danenberg, K.D.3    Danenberg, P.V.4    Groshen, S.5
  • 15
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichma CG, Lenz HJ, Leichman L, Danenberg K, Baranda J et al. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 1997; 15:3223-3229.
    • (1997) J Clin Oncol , vol.15 , pp. 3223-3229
    • Leichma, C.G.1    Lenz, H.J.2    Leichman, L.3    Danenberg, K.4    Baranda, J.5
  • 16
    • 0032997572 scopus 로고
    • Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastasis predicts for clinical outcome of fluorouracil-based chemotherapy
    • Aschele C, Debernardis D, Casazza S, Antonelli G, Tunesi C et al. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastasis predicts for clinical outcome of fluorouracil-based chemotherapy. J Clin Oncol 1990; 17:1760-1770.
    • (1990) J Clin Oncol , vol.17 , pp. 1760-1770
    • Aschele, C.1    Debernardis, D.2    Casazza, S.3    Antonelli, G.4    Tunesi, C.5
  • 17
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FMN, Kouni MH, and Cha S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 1985; 45:5405-5412.
    • (1985) Cancer Res , vol.45 , pp. 5405-5412
    • Naguib, F.M.N.1    Kouni, M.H.2    Cha, S.3
  • 18
    • 0034012706 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: Possible predictor for sensitivity to 5-fluorouracil
    • Ishikawa Y, Kubota T, Otani Y, Watanabe M, Teramoto T et al. Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil. Jpn J Cancer Res 2000; 91:105-112.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 105-112
    • Ishikawa, Y.1    Kubota, T.2    Otani, Y.3    Watanabe, M.4    Teramoto, T.5
  • 19
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S et al. Colorectal tumors responding to 5-fluouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 2000; 6:1322-1327.
    • (2000) Clin Cancer Res , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3    Metzger, R.4    Groshen, S.5
  • 20
    • 0028982820 scopus 로고
    • Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity
    • Etinne MC, Cheradame S, Fischel JL, Formento P, Dassonville O et al. Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 1995; 13:1633-1670.
    • (1995) J Clin Oncol , vol.13 , pp. 1633-1670
    • Etinne, M.C.1    Cheradame, S.2    Fischel, J.L.3    Formento, P.4    Dassonville, O.5
  • 21
    • 0029918519 scopus 로고    scopus 로고
    • Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population
    • McMurrough J, and McLeod HL. Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population. Br J Clin Pharmacol 1996; 41:425-427.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 425-427
    • McMurrough, J.1    McLeod, H.L.2
  • 22
    • 0027231283 scopus 로고
    • Drug sensitivity test for primary culture of human cancer cells using collagen gel embedded culture and image analysis
    • Koezuka M, Kondo N, Kobayashi H, Hara S, and Yasutomi M. Drug sensitivity test for primary culture of human cancer cells using collagen gel embedded culture and image analysis. Int J Oncol 1993; 2:953-959.
    • (1993) Int J Oncol , vol.2 , pp. 953-959
    • Koezuka, M.1    Kondo, N.2    Kobayashi, H.3    Hara, S.4    Yasutomi, M.5
  • 23
    • 0028882837 scopus 로고
    • Development of new in vitro chemosensitivity test using collagen-gel droplet embedded culture and its clinical usefulness
    • Kobayashi H, Tanisaka K, Kondo N, Mito Y, and Koezuka M. Development of new in vitro chemosensitivity test using collagen-gel droplet embedded culture and its clinical usefulness. Jpn J Cancer Chemothe 1995; 22:1933-1939.
    • (1995) Jpn J Cancer Chemothe , vol.22 , pp. 1933-1939
    • Kobayashi, H.1    Tanisaka, K.2    Kondo, N.3    Mito, Y.4    Koezuka, M.5
  • 24
    • 0021004809 scopus 로고
    • Significance of three-dimensional growth patterns of mammary tissues in collagen gels
    • Lawler EM, Miller FR, and Heppner GH. Significance of three-dimensional growth patterns of mammary tissues in collagen gels. In Vitro 1983; 19:600-610.
    • (1983) In Vitro , vol.19 , pp. 600-610
    • Lawler, E.M.1    Miller, F.R.2    Heppner, G.H.3
  • 25
    • 0020644763 scopus 로고
    • Growth of cultured cells using collagen as substrate
    • Yang J, and Nandi S. Growth of cultured cells using collagen as substrate. Int Rev Cytol 1983; 81:249-286.
    • (1983) Int Rev Cytol , vol.81 , pp. 249-286
    • Yang, J.1    Nandi, S.2
  • 26
    • 0033397649 scopus 로고    scopus 로고
    • An in vitro chemosensitivity test for colorectal cancer using collagen-gel droplet embedded cultures
    • Araki Y, Isomoto H, Matsumoto A, Kaibara A, Yasunaga M et al. An in vitro chemosensitivity test for colorectal cancer using collagen-gel droplet embedded cultures. Kurume Med J 1999; 46:163-166.
    • (1999) Kurume Med J , vol.46 , pp. 163-166
    • Araki, Y.1    Isomoto, H.2    Matsumoto, A.3    Kaibara, A.4    Yasunaga, M.5
  • 27
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil
    • Beck A, Etienne MC, Cheradame S, Fischel JL, Formento P et al. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 1994; 30:1517-1522.
    • (1994) Eur J Cancer , vol.30 , pp. 1517-1522
    • Beck, A.1    Etienne, M.C.2    Cheradame, S.3    Fischel, J.L.4    Formento, P.5
  • 28
    • 0342836651 scopus 로고    scopus 로고
    • Thymidine kinase, thymidylate synthase, dihydropyrimidine dehydrogenase & p53 profiles of cell lines in the National Cancer Institute anticancer drug screen
    • Germ J, Danenberg K, Behan K, Parr A, Young L et al. Thymidine kinase, thymidylate synthase, dihydropyrimidine dehydrogenase & p53 profiles of cell lines in the National Cancer Institute anticancer drug screen. Am Asso Cancer Res 1999; 40:8.
    • (1999) Am Asso Cancer Res , vol.40 , pp. 8
    • Germ, J.1    Danenberg, K.2    Behan, K.3    Parr, A.4    Young, L.5
  • 29
    • 0003293866 scopus 로고    scopus 로고
    • High thymidylate synthase expression does not pre-clude activity of CPT-11 in colorectal cancer
    • Saltz L, Danenberg K, Paty P, Kelsen D, Kemeny N et al. High thymidylate synthase expression does not pre-clude activity of CPT-11 in colorectal cancer. Proc Am Soc Clin Oncol 1998; 17:28.
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 28
    • Saltz, L.1    Danenberg, K.2    Paty, P.3    Kelsen, D.4    Kemeny, N.5
  • 30
    • 0033186036 scopus 로고    scopus 로고
    • A patient preference study comparing raltitrexed (Tomudex) and bolus or infusional 5-fluorouracil regimens in advanced colorectal cancer: Influence of side effects and administration attributes
    • Young A, Topham C, and Moore J. A patient preference study comparing raltitrexed (Tomudex) and bolus or infusional 5-fluorouracil regimens in advanced colorectal cancer: influence of side effects and administration attributes. Eur J Cancer Care 1999; 8:154-161.
    • (1999) Eur J Cancer Care , vol.8 , pp. 154-161
    • Young, A.1    Topham, C.2    Moore, J.3
  • 31
    • 0033975358 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of oral fluouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil
    • Baker SD, Diasio RB, O'Reilly S, Lucas VS, Khor SP et al. Phase I and pharmacologic study of oral fluouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil. J Clin Oncol 2000; 18:915-926.
    • (2000) J Clin Oncol , vol.18 , pp. 915-926
    • Baker, S.D.1    Diasio, R.B.2    O'Reilly, S.3    Lucas, V.S.4    Khor, S.P.5
  • 32
    • 0032784111 scopus 로고    scopus 로고
    • Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors
    • Ahmed FY, Johnston SJ, Cassidy J, O'Kelly T, Binnie N et al. Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors. J Clin Oncol 1999; 17:2439-2445.
    • (1999) J Clin Oncol , vol.17 , pp. 2439-2445
    • Ahmed, F.Y.1    Johnston, S.J.2    Cassidy, J.3    O'Kelly, T.4    Binnie, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.