Cardioactive agents from plants

Mini-Reviews in Medicinal Chemistry

Volumn 9, Issue 7, 2009, Pages 878-899

  Gutiérrez, Rosa Martha Pérez ^a   Baez, Efren Garcia ^b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Antiarrhythmic; Bradycardiac; Heart disease; Hypertensive; Thrombosis; Vasorelaxing

Indexed keywords

AJMALINE; ALLICIN; BEBEERINE; BERGAMOTTIN; BERGENIN; CHRYSIN; COCLAURINE; DAIDZEIN; DAURICINE; EUGENOL; FANGQUINOLINE; FERULIC ACID; FORSKOLIN; GENISTEIN; HIGENAMINE; HYPOXANTHINE ARABINOSIDE; INOTROPIC AGENT; ISORHAMNETIN; NANTENINE; NARINGENIN; OCIMUM GRATISSIMUM EXTRACT; QUERCETIN; QUERCETIN 3 METHYL ETHER; QUINIDINE; RESERPINE; RUTAECARPINE; STEVIOSIDE; TETRANDRINE; TRIPTOLIDE; UNINDEXED DRUG; CARDIOVASCULAR AGENT; PLANT EXTRACT;

ANTIHYPERTENSIVE ACTIVITY; CONCENTRATION RESPONSE; CORONARY ARTERY SPASM; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; ETHNOPHARMACOLOGY; HEART ARRHYTHMIA; HEART DISEASE; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HERBAL MEDICINE; HUMAN; HYPERTENSION; INTRAOCULAR HYPERTENSION; MEDICINAL PLANT; NONHUMAN; PSYCHOSIS; REVIEW; RHEUMATOID ARTHRITIS; STEREOCHEMISTRY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS; VASODILATATION; ANIMAL; CHEMISTRY; ISOLATION AND PURIFICATION; PLANT;

ANIMALS; CARDIOVASCULAR AGENTS; HEART DISEASES; HUMANS; PLANT EXTRACTS; PLANTS; PLANTS, MEDICINAL;

EID: 68849087151     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955709788452612     Document Type: Review

References (79)

1. Petkov, V. Plants with Hypotensive, antiatheromatous and coronarodilatating Action. Am. J. Chin. Med., 1979, 7, 197-236.
2. Almeshal, L.A.; Ageel, A.M.; Parmar, N.S. Tariq, M. Catha edulis (Khat): Use, abuse and current status of scientific knowledge. Fitoterapia, 1985, LXL, 131-51.
3. Celidarque, S.D.; Barbosa-Filho, J.M.; Virginia, S.L.; Cortes, S.F. Mechanisms involved in the vasodilator effect of curine in rat resistance arteries. Planta Med., 2002, 68, 1049-51.
4. Yun-Choi, H.S.; Pym, M.K.; Park K.M.; Chang, K.C.; Lee, D.H. Anti-thrombotic effects of higenamine. Planta Med., 2001, 67, 619-22.
5. Ojewole, J.A.O.; Adesina S.K. Effects of hypoxanthine-9-Larabinofuranoside, a nucleoside from the roots of Boerhaavia diffusa L. (Nyctaginaceae) on isolated coronary artery of the Goat. J. Nat. Prod., 1999, 62, 163-69.
6. Villar, A.; Paya M.; Terencio, M.C. Plants with antihypertensive action. Fitoterapia. 1986, LVII, 131-45.
7. Schmeda-Hirschmann, G.; Loyola, J.I.; Rodríguez, J. Hypotensive effect of Laurelia sempervirens (Monimiaceae) on normotensive rats. Phytother. Res., 1994, 8, 49-51.
8. Orallo, F.; Alzuela, A.F. Preliminary study of the vasorelaxant effects of (+)-Nantenine, an alkaloid isolated from Platycapnos spicata, in Rat Aorta. Planta Med., 2001, 67, 800-06.
9. Faizi, S.; Siddiqui, B.S.; Saleem, R.; Siddiqui, S. Aftab, K: Isolation and structure elucidation of new nitrile and mustard oil glycosides from Aforinga oleifera and their effect on blood pressure. J. Nat. Prod., 1994, 57, 1256-61.
10. Gilani, A.H.; Aftab, K.; Suria, A. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytother. Res., 1994, 8, 87-91.
11. Marczak, E.D.; Usui, H.; Fujita, H.; Yang, Y.; Yokoo, M.; Lipkowski, A.W.; Yoshikawa, M. New antihypertensive peptides isolated from rapeseed. Peptides, 2003, 24, 791-98.
12. Yang, H.Y.; Yang, S.C.; Chen, J.R.; Tzeng, Y.H.; Han, B.C. Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats. Br. J. Nutr., 2004, 92, 507-12.
13. Yang, Y.; Marczak, E.D.; Usui, H.; Kawamura; Y.; Yoshikawa, M. Antihypertensive properties of spinach leaf protein digests. J. Agric. Food. Chem., 2004a, 52, 2223-25.
14. Djerassi, C. ; Connolly, J.D. ; Faulkner, D.J. Dictionary of natural products. Chapman & Hall. London. 1994.
15. Hu, C.; Xiao, L.; Deng, H.; Li Y. The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-Related peptide. Planta Med., 2003, 69, 125-29.
16. Achenbach, H.;Hubner, H.; Vierling, W.; Brandt, W.; Reiter, M. Spiganthine, the cardiactive principle of. Spigelia anthelmia J. Nat. Prod., 1995, 58, 1092-96.
17. Gao, S.; von Shumann, G.; Stockigt, J. A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline. Planta Med., 2002, 68, 906-11.
18. Chen, J.; Chang, Y.; Teng, C.; Chen, I. Vasorelaxing and antioxidant constituents from Hernandia nymphaeifolia. Planta Med., 2001, 67, 593-98.
19. Morales, M.A.; Bustamante, S.E.; Brito, G.; Paz, D.; Cassels, B.K. Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine. Phytother. Res., 1998, 12, 103-09.
20. Mok, S.; Ranagasundaram, Y.; Lim, T.; Ram, T. Cardiovascular effects of aspidofractinine-type alkaloids from Kopsia. J. Nat. Prod., 1998, 61, 328-32.
21. Magos, G.A.; Vidrio, H.; Reynolds, W.F. Pharmacology of Casimiroa edulis IV. Hypotensive effects of compounds isolated from methanolic extracts in rats and guinea pigs. J. Ethnopharmacol., 1999, 64, 35-44.
22. Kim, H.; Zhang, Y.; Oh, K.; Ahn, H.Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat. J. Ethnopharmacol., 1997, 58, 117-23.
23. Qian, J.Q. Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol Sin., 2002, 23, 1086-92.
24. Rakotoarison, O.; Rabenau, I.; Lobstein, A.; Um, B.; Schott C.; Anton, R.; Randriantsoa, A.; Andriantsitohaina R. Vasorelaxing properties and Bio-guided fractionation of Cedrelopsis grevei. Planta Med., 2003, 69, 179-81.
25. Chiou, W.; Huang, Y.; Chen, C.; Chiou, W.; Huang, Y. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit Corpus Cavernosum. Planta Med., 2001, 67, 282-83.
26. Rauwald, H.W.; Brehm, O.; Odenthal, K.P. Screening of nine vasoactive medicinal plants for their possible calcium antagonistic activity. strategy of selection and isolation for the active principles of Olea europaea and Peucedanum ostruthium. Phytother. Res., 1994, 8, 135-40.
27. Duarte, J.; Jimenez, R.; Concepción, I.V.; Perez-Vizcaino, F.; Jimenez, J.; Tamargo, J. Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta. Planta Med., 2001, 67, 567-69.
28. Laekeman, G.M.; Galéis, M.; Rwangabo, P.C.; Herman, A.G., Vlietinck, A.J. Cardiovascular effects of 3-methylquercetin. Planta Med., 1986, 52, 433-37.
29. Sanchez de Rojas, V.R.; Somoza, B.; Ortega, T.; Villar A. Vasodilatory effect of naringenin in rat aorta. Phytother. Res., 1996, 10, S123-S25.
30. Souza, M.F.; Cunha, G.M.A.; Fontenele, J.B.; Viana, G.S.B.; Rao, V.S.N. Antithrombotic activity of ternatin, a tetramethoxy flavone from Egletes viscosa Less. Phytother. Res., 1994, 8, 478-81.
31. Ibarra, M.; Perez-Vizcaino, F.; Cogollado, A.; Duarte, J.; Zaragoza-Arnaez, F.; López-López, J.G.; Tamargo, J. Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. Planta Med., 2002, 68, 307-10.
32. Lahlou, S.; Interaminense, L.F.; Leal-Cardoso, JH.; Duarte, G.P. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam. Clin. Pharmacol., 2003, 17, 323-30.
33. Mpalantinos, M.A.; Soares de Moura, R., Parente, J.P., Kuster, R.M. Biologically active flavonoids and kava pyrones from the Aqueous extract of Alpinia zerumbet. Phytother. Res., 1998, 12, 442-44.
34. Matsuura, M.; Kimura, Y.; Nakata, K.; Baba, K.; Okuda, H. Artery relaxation by chalcones isolated from the roots of Angelica keiskei. Planta Med., 2001, 67, 230-35.
35. Ogawa, H.; Okada, Y.; Kamisako, T.; Baba, K. Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., 2007, 34, 238-43.
36. Shin, J.I.; Park, O.J.; Kang, M.H. Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol., 2005, 51, 254-59.
37. Ogawa, H.; Ohno, M.; Baba, K. Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., 2005, 32, 19-23.
38. Waterhouse, A.L. Wine and heart disease. Wine Health., 2003, 1-6.
39. Interaminense, L.F.; Leal-Cardoso, J.H.; Magalhaes, P.J.; Duarte, G.P.; Lahlou, S: Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats. Planta Med., 2005, 71, 376-78.
40. Galal, E.E.; Kandil, A.; Latif, M.A.; Khedr, T.; Khafagy, S.M. Cardiac pharmaco-toxicological studies of judaicin isolated from Artemisia Judaica. Fitoterapia, 1988, 59, 88-89.
41. Durbey, M.P.; Srimal, R.C.; Nityanand, S.; Dhawan, B.N. Pharmacological studies on coleonol, a hypotensive sditerpene from Coleus forskohlii. J. Ethnopharmacol., 1981, 3, 1-13.
42. Sanae, E. B.; Morel, N.; Wibo, M.; Fabre, I N.; Llabres, G.; Lyoussi, B.; Quetin-Leclercq, J. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med., 2003, 69, 75-77.
43. Adewunmi, C.O.; and Aladesanmi, A.J. On the cardiovascular activity of compounds isolated from the leaf extract of Dysoxylum lenticellare. Fitoterapia, 1988, 59, 435-39.
44. Guedes, D.N.; Silva, D.F.; Barbosa-Filho, J.M.; Medeiros, I.A. Muscarinic agonist properties 1nvolved in the hypotensive and vasorelaxant eesponses of rotundifolone in rats. Planta Med., 2002, 68, 700-04.
45. Ambrosio, S.R.; Tirapelli, C.R.; Bonaventura, D.; De Oliveira, A.M.; Da Costa, F.B. Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction. Fitoterapia., 2002, 73, 484-89.
46. Hu, K.; Liu, Z.; Liu, D.; Li, L. Inhibition of vascular endothelial growth factor expression and production by triptolide. Planta Med., 2002, 68, 368-69.
47. Ulubelen, A.; Birman, H.; Oksiiz, S.; Topcu, G.; Kolak, U.; Barla, A.; Voelter, W. Cardioactive diterpenes from the roots of Salvia eriophora. Planta Med., 2002, 68, 818-21.
48. Somova, L.I.; Shode, F.O.; Moodley, G.Y. Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica. J. Ethnopharmacol., 2001, 77, 165-74.
49. Kolak, U.S.; Ari S.; Birman H.; Hasancebi S.; Ulubelen A. Cardioactive diterpenoids from the roots of Salvia amplexicaulis. Planta Med., 2001, 67, 761-63.
50. Ulubelen, A.; Oksuz, S.; Kolak, U.; Birman, H.; Voelter, W. Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca. Planta Med., 2000, 66, 627-29.
51. Vasovic, V.; Vukmirovic, S.; Posa, M.; Mikov, M.; Raskovic, A.; Jakovljevic, V. Effect of rat pretreatment with aqueous solutions of stevioside and bile acids on the action of certain cardioactive drugs. Eur. J. Drug Metab. Pharmacokinet., 2006, 31, 311-14.
52. Pennacchio, M.; Syah, Y.M.; Ghisalberti, E.M.; Alexander, E. Cardioactive compounds from Eremophila species. J. Ethnopharmacol., 1996, 53, 21-27.
53. Hsu, F.; Lee, Y.; Cheng, J. Antihypertensive activity of 6-OGalloyl-D-glucose, A phenolic glycoside from Sapium sebiferum. J. Nat. Prod., 1994, 57, 308-12.
54. Watanabe, T.; Arai, Y.;Mitsui, Y.; Kusaura, T.; Okawa, W.; Kajihara, Y.; Saito, I. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin. Exp. Hypertens., 2006, 28, 439-49.
55. Wang, B.H.; Ou-Yang, J.P. Pharmacological actions of sodium ferulate in cardiovascular system. Cardiovasc. Drug Rev., 2005, 23, 161-72.
56. Suzuki, A.; Kagawa, D.; Fujii, A.; Ochiai, R.;Tokimitsu, I.; Saito, I. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am. J. Hypertens, 2002, 15, 351-57.
57. Chang, W.; Su, M.; Lee, S. Bioactive norlignan glucosides from Curculigo capitulata. J. Nat. Prod., 1997, 60, 76-80.
58. Oh, H. ; Kang, D.; Lee, S.; Lee, H. Angiotensin converting enzyme inhibitors from Cuscuta japonica Choisy. J. Ethnopharmacol., 2002, 83, 105-08.
59. Li, H.; Xia, N.; Brausch, I.; Yao, Y.; Forstermann, U. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J. Pharmacol. Exp. Ther., 2004, 310, 926-32.
60. Molina, V.; Arruzazabala, M.L.; Carbajal, D.; Mas, R. D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolites. Prostaglandins Leukot. Essent. Fatty Acids, 2002, 67, 19-24.
61. Kongkathip, N.; Dhumma-upakorn, P.; Kongkathip, B.; Chawananoraset K.; Sangchomkaeo P.; Hattha- kitpanichakul, S. Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa. J. Ethnopharmacol., 2002, 83, 95-99.
62. Mahato, S.B.; Sarkar, S.K.; Poddar, G. Triterpenoids saponins. Phytochemistry, 1988, 27, 3037-67.
63. Da Silva Antunes A, Da Silva BP, Parente JP, Valente AP. A new bioactive steroidal saponin from Sansevieria cylindrica. Phytother. Res. 2003, 17, 179-82.
64. Yang, S.; Qu, J.; Zhong, G.; Zhang, W. Protective effects of Panax quinquefolium saponin on oxidative damage of cultured rat cardiac cells. Zhongguo Zhong Yao Za Zhi., 1992, 17, 555-57.
65. Chu, T.C.; Ogidigben, M.; Han, J.C. Allicin-induced hypotension in rabbit eyes. J. Ocul. Pharmacol., 1993, 9, 201-09.
66. Occhiuto F.; and Circosta C. Antianginal and antiarrhythmic effects of bergarnottine, a furocoumarin isolated from Bergamot oil. Phytother. Res., 1996, 10, 491-496.
67. Pu H., Huang X., Zhao J., Hong A. Bergenin is the antiarrhythmic principle of Fluggea virosa. Planta Med., 2002, 68, 372-74.
68. Othman, R.; Ibrahim, H., Ali Mohd, M., Awang, K., Hassan, A., Gilanj, Mohd G., Mustafa, R. Vasorelaxant effects of ethyl cinnamate isolated from kaempferia galanga on smooth muscles of the rat aorta. Planta Med., 2002, 68, 652-55.
69. Hussein, M.M.; Helmy, W.A.; Salem, H.M. Biological activities of some galactomannans and their sulfated derivatives. Phytochemistry, 1998, 49, 479-84.
70. Beltran, A.E.; Alvarez, Y.; Xavier, F.E.; Hernanz, R.; Rodriguez, J.; Nunez, A.J.; Alonso, M.J.; Salaices, M. Vascular effects of the Mangifera indica L. extract (Vimang). Eur. J. Pharmacol., 2004, 499, 297-305.
71. Ahmad, M.; and Aftab, K. Hypotensive action of syringin from Syringa vulgaris. Phytother. Res., 1995, 9, 448-51.
72. Bombardelli, E.G.; Guglielmini, G.P.; Morazzoni P. Microvasculokinetic activity of ximenynic acid ethyl ester. Fitoterapia., 1994, LXV, 195-201.
73. Essman, E.J. The medicinal uses of herbs. Fitoterapia, 1984, LV, 279-89.
74. Saleem, R. ; Faizi,S.; Siddiqui, B.S.; Ahmed, M.; Hussain, S.A.; Qazi, A.; Dar, A..; Ahmad, S.I.; Qazi, M.H.; Akhtar S.; Hasnain, S.N. Hypotensive effect of chemical constituents from Aloe barbadensis. Planta Med., 2001, 67, 757-760.
75. Tsi, D.; and Tan, B.K.H. Cardiovascular pharmacology of 3-nbutylphthalide in spontaneously hypertensive rats. Phytother. Res,. 1997, 11, 576-82.
76. Zhao, Y.N.; Pan, Y:, Tao, J.L.; Xing, D.M.; Du, L.J. Study on cardioactive effects of brazilein plants. Pharmacology., 2006, 76, 76-83.
77. Saleem, R.; Ahmad, M., Naz, A., Siddiqui, H., Ahmad, S.I., Faizi, S. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch. Pharm. Res., 2004, 27, 1037-42.
78. Suzuki, Y.; Kondo, K.; Ikeda Y.; Umemura K. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med., 2001, 67, 807-10.
79. Harper, C.R.; Jacobson, T.A. Beyond the Mediterranean diet: the role of omega-3 Fatty acids in the prevention of coronary heart disease. Prev. Cardiol., 2003, 6, 136-46.