메뉴 건너뛰기




Volumn 68, Issue 10, 2002, Pages 906-911

A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline

Author keywords

1,2 dihydrovomilenine reductase; Ajmaline biosynthesis; Apocynaceae; Cell suspension culture; Rauvolfia serpentina Benth. ex Kurz

Indexed keywords

1,2 DIHYDROVOMILENINE REDUCTASE; AJMALINE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

EID: 0036774746     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-34935     Document Type: Article
Times cited : (20)

References (21)
  • 1
    • 0000077649 scopus 로고
    • Chemical examination of the roots of Rauwolfia serpentina, Benth
    • Siddiqui S, Siddiqui RH. Chemical examination of the roots of Rauwolfia serpentina, Benth. J. Ind. Chem. Soc. 1931; 8: 667-81
    • (1931) J. Ind. Chem. Soc. , vol.8 , pp. 667-681
    • Siddiqui, S.1    Siddiqui, R.H.2
  • 2
    • 0000660875 scopus 로고
    • The alkaloids of Rauwolfia serpentina, Benth. Part I
    • Siddiqui S, Siddiqui RH. The alkaloids of Rauwolfia serpentina, Benth. Part I. J. Ind. Chem. Soc. 1932; 9: 539-44
    • (1932) J. Ind. Chem. Soc. , vol.9 , pp. 539-544
    • Siddiqui, S.1    Siddiqui, R.H.2
  • 3
    • 0000586752 scopus 로고
    • Klinische untersuchungen über die wirkungsweise des rauwolfia alkaloids ajmalin bei herzrhythmus-störungen, insbesondere bei extrasystolie
    • Kleinsorge H. Klinische untersuchungen über die wirkungsweise des rauwolfia alkaloids ajmalin bei herzrhythmus-störungen, insbesondere bei extrasystolie. Med. Klin. 1959; 54: 409-12
    • (1959) Med. Klin. , vol.54 , pp. 409-412
    • Kleinsorge, H.1
  • 4
    • 4243939823 scopus 로고
    • Rauwolfia alkaloide
    • Kähler HJ, editor. Boehringer Mannheim GmbH
    • Kähler HJ. Rauwolfia alkaloide. In: Kähler HJ, editor. Boehringer Mannheim GmbH, 1970: 99-105
    • (1970) , pp. 99-105
    • Kähler, H.J.1
  • 5
    • 4243949725 scopus 로고
    • Pharmakologie der rauwolfia
    • Kroneberg G. Pharmakologie der rauwolfia. Planta Medica 1957; 5/6: 156-65
    • (1957) Planta Medica , vol.5-6 , pp. 156-165
    • Kroneberg, G.1
  • 6
    • 0002339015 scopus 로고
    • Indole alkaloids from cell suspension cultures of Rauwolfia serpentina Benth
    • Stöckigt J, Pfitzner A, Firl J. Indole alkaloids from cell suspension cultures of Rauwolfia serpentina Benth. Plant Cell Reports 1981; 1: 36-9
    • (1981) Plant Cell Reports , vol.1 , pp. 36-39
    • Stöckigt, J.1    Pfitzner, A.2    Firl, J.3
  • 8
    • 77957065322 scopus 로고
    • The alkaloids. Biosynthesis in Rauwolfia Serpentina. Modern aspects of an old medicinal plant
    • Cordell GA, editor. Vol. 47 New York: Academic Press
    • Stöckigt J. The Alkaloids. Biosynthesis in Rauwolfia Serpentina. Modern Aspects of an Old Medicinal Plant. In: Cordell GA, editor. Vol. 47 New York: Academic Press, 1995: 115-72
    • (1995) , pp. 115-172
    • Stöckigt, J.1
  • 9
    • 0025878733 scopus 로고
    • Enzymology and molecular biology of alkaloid biosynthesis
    • Kutchan TM, Dittrich H, Bracher D, Zenk MH. Enzymology and molecular biology of alkaloid biosynthesis. Tetrahedron 1991; 47: 5945-54
    • (1991) Tetrahedron , vol.47 , pp. 5945-5954
    • Kutchan, T.M.1    Dittrich, H.2    Bracher, D.3    Zenk, M.H.4
  • 10
    • 0000667057 scopus 로고    scopus 로고
    • The gene encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosynthesis in plants in an ortholog of the α/β hydrolase super family
    • Dogru E, Warzecha H, Seibel F, Haebel S, Lottspeich F, Stöckigt J. The gene encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosynthesis in plants in an ortholog of the α/β hydrolase super family. Eur. J. Biochem. 2000; 267: 1397-406
    • (2000) Eur. J. Biochem. , vol.267 , pp. 1397-1406
    • Dogru, E.1    Warzecha, H.2    Seibel, F.3    Haebel, S.4    Lottspeich, F.5    Stöckigt, J.6
  • 11
    • 0034705965 scopus 로고    scopus 로고
    • Molecular cloning and functional bacterial expression of a plant glucosidase specifically involved in alkaloid biosynthesis
    • Warzecha H, Gerasimenko I, Kutchan TM, Stöckigt J. Molecular cloning and functional bacterial expression of a plant glucosidase specifically involved in alkaloid biosynthesis. Phytochemistry 2000; 54: 657-66
    • (2000) Phytochemistry , vol.54 , pp. 657-666
    • Warzecha, H.1    Gerasimenko, I.2    Kutchan, T.M.3    Stöckigt, J.4
  • 12
    • 84982378007 scopus 로고
    • Organic growth factor requirements of tobacco tissue cultures
    • Linsmaier EM, Skoog F. Organic growth factor requirements of tobacco tissue cultures. Physiol. Plant. 1965; 18: 100-27
    • (1965) Physiol. Plant , vol.18 , pp. 100-127
    • Linsmaier, E.M.1    Skoog, F.2
  • 13
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 14
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 16
    • 0017088267 scopus 로고
    • Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
    • Yasukochi Y, Masters BSS. Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. J. Biol. Chem. 1976; 251: 5337-44
    • (1976) J. Biol. Chem. , vol.251 , pp. 5337-5344
    • Yasukochi, Y.1    Masters, B.S.S.2
  • 17
    • 0018865166 scopus 로고
    • Chromogenic reactions of Rauvolfia alkaloids after separation by thin-layer chromatography
    • Court WE, Iwu MM. Chromogenic reactions of Rauvolfia alkaloids after separation by thin-layer chromatography. Chrom. 1980; 187: 199-207
    • (1980) Chrom. , vol.187 , pp. 199-207
    • Court, W.E.1    Iwu, M.M.2
  • 18
    • 37049097194 scopus 로고
    • Polyneuridine aldehyde esterase: An unusually specific enzyme involved in the biosynthesis of sarpagine type alkaloids
    • Pfitzner A, Stöckigt J. Polyneuridine aldehyde esterase: An unusually specific enzyme involved in the biosynthesis of sarpagine type alkaloids. J. Chem. Soc. Chem. Commun. 1983: 459-60
    • (1983) J. Chem. Soc. Chem. Commun. , pp. 459-460
    • Pfitzner, A.1    Stöckigt, J.2
  • 19
    • 84942698835 scopus 로고
    • Properties of vinorine synthase - The Rauwolfia enzyme involved in the formation of the ajmaline skeleton
    • Pfitzner A, Polz L, Stöckigt J. Properties of vinorine synthase - The Rauwolfia enzyme involved in the formation of the ajmaline skeleton. Z. Naturforsch. 1986; 41c: 103-14
    • (1986) Z. Naturforsch. , vol.41 C , pp. 103-114
    • Pfitzner, A.1    Polz, L.2    Stöckigt, J.3
  • 20
    • 0029161223 scopus 로고
    • Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway; catalyzed by a novel cytochrome P 450-dependent enzyme from plant cell cultures of Rauwolfia serpentina
    • Falkenhagen H, Stöckigt J. Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway; catalyzed by a novel cytochrome P 450-dependent enzyme from plant cell cultures of Rauwolfia serpentina. Z. Naturforsch. 1995; 50c: 45-53
    • (1995) Z. Naturforsch. , vol.50 C , pp. 45-53
    • Falkenhagen, H.1    Stöckigt, J.2
  • 21
    • 0023320603 scopus 로고
    • Characterization of 2β(R)-17-O-acetyl-ajmalan: Acetylesterase - A specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline
    • Polz L, Schübel H, Stöckigt J. Characterization of 2β(R)-17-O-acetyl-ajmalan: acetylesterase - A specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline. Z. Naturforsch. 1987; 42c: 333-42
    • (1987) Z. Naturforsch , vol.42 C , pp. 333-342
    • Polz, L.1    Schübel, H.2    Stöckigt, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.