Effect of rat pretreatment with aqueous solutions of stevioside and bile acids on the action of certain cardioactive drugs

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 31, Issue 4, 2006, Pages 311-314

  Vasović, Velibor ^a   Vukmirović, Saša ^a   Poša, Mihalj ^a   Mikov, Momir ^b   Rašković, Aleksandar ^a   Jakovljević, Vida ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Bile acids; Metoprolol; Stevioside adrenaline interaction; Verapamil

Indexed keywords

ADRENALIN; BILE ACID; ESTER DERIVATIVE; INOTROPIC AGENT; IZOPAMIL; METOPROLOL; MONOKETOCHOLIC ACID METHYL ESTER; SODIUM; STEVIOSIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SENSITIZATION; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HEART VENTRICLE EXTRASYSTOLE; MALE; NONHUMAN; QRS COMPLEX; RAT; SINGLE DRUG DOSE;

EID: 33846958795     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190472     Document Type: Article

References (8)

1. Lee L. (2002): Natural no calories, and sweeter than sugar. www. Radiobookstore.com/stevia.htm.
2. Jeppesen P.B., Gregersen S., Alstrup K.K., Hermansen K. (2002): Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki rats. Phytomedicine, 9; 9-14.
3. Melis M.S. (1992): Stevioside effect on renal function of normal and hypertensive rats. J. Ethnopharmacol., 36; 213-217.
4. Melis M.S. (1995): Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J. Ethnopharmacol., 47; 129-134.
5. Armstrong M.J., Carez M.C. (1982): The hydrophobic-hydrophilic balance of bile salts: inverse correlation between reverse-phase high performance liquid chromatography mobilities and micellar cholesterol solubilizing capacities. J. Lipid Res., 23; 70-80.
6. Kuhajda K., Kandra_ J. Mikov M. (1999): Bile acids. Monograph, University of Novi Sad, PMF. OrtoMedics, Novi Sad (in Serbian).
7. Turner R.A. (1965): Screening methods in pharmacology. Academic Press, New York and London, p. 144.
8. Vasovic V., Raskovic A., Jakovljevic V., Nesic M (2002): Effect of rat pretreatment with aqueous solution of Stevia rebaudiana and cardioactive drugs on heart evidenced as the changes in ECG. Iugoslav Physiol. Pharmacol. Acta, (in Serbian).