Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 3, 2007, Pages 238-243

  Ogawa, Hiroshi ^a   Okada, Yukiko ^b   Kamisako, Toshinori ^a   Baba, Kimiye ^b  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Angelica keiskei; Chalcone; Lipid metabolism; Reverse transcription polymerase chain reaction; Stroke prone spontaneously hypertensive rats; Xanthoangelol

Indexed keywords

ACYL COENZYME A OXIDASE; CHALCONE DERIVATIVE; CHOLESTEROL; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; XANTHOANGELOL;

ANGELICA KEISKEI; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; FECES; FOOD INTAKE; GENE EXPRESSION; HYPERLIPIDEMIA; HYPERTENSION; LIPID METABOLISM; LIVER WEIGHT; MALE; MEDICINAL PLANT; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

ANGELICA; ANIMALS; APOLIPOPROTEINS; BLOOD PRESSURE; CEREBROVASCULAR ACCIDENT; CHALCONE; DIET; ENZYME INHIBITORS; FECES; GLUCOSE; LIPID METABOLISM; LIPIDS; LIPOPROTEINS; LIVER; PLANT STEMS; RATS; RATS, INBRED SHR;

EID: 33846425696     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04578.x     Document Type: Article

References (29)

1. +-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin from Angelica keiskei Koidzumi. J. Pharm. Pharmacol. 1990; 42: 723-6.
2. Okuyama T, Takata M, Takayasu J et al. Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991; 57: 242-6.
3. Kimura Y, Baba K. Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol. Int. J. Cancer 2003; 106: 429-37.
4. Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004; 70: 211-19.
5. Fujita T, Sakuma S, Sumiya T et al. The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit. Res. Commun. Chem. Pathol. Pharmacol. 1992; 77: 227-40.
6. Shimizu E, Hayashi A, Takahashi R, Aoyagi Y, Murakami T, Kimoto K. Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. 1999; 45: 375-83.
7. Matsuura M, Kimura Y, Nakata K, Baba K, Okuda H. Artery relaxation by chalcones isolated from the roots of Angelica keiskei. Planta Med. 2001; 67: 230-5.
8. Ogawa H, Nakashima S, Baba K. Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 2003; 30: 284-8.
9. Ogawa H, Ohno M, Baba K. Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 2005; 32: 19-23.
10. Ogawa H, Nakamura R, Baba K. Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 2005; 32: 1104-9.
11. Aitman TJ, Gotoda T, Evans AL et al. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat. Genet. 1997; 16: 197-201.
12. Okamoto K, Yamori Y, Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ. Res.1974; 34, 35: 143-53.
13. Reeves PG, Rossow KL. Development and testing of the AIN-93 purified diets for rodents. Results on growth, kidney calcification and bone mineralization in rats and mice. J. Nutr. 1993; 123: 1923-31.
14. Quarfordt SH, Jain RS, Jakoi L, Robinson S, Shelburne F. The heterogeneity of rat high density lipoproteins. Biochem. Biophys. Res. Commun. 1978; 83: 786-93.
15. Folch J, Lee M, Stanley GHS. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957; 226: 497-509.
16. Laurell CB. Quantitative estimation of proteins by electrophoresis in agarose-gel containing antibodies. Anal. Biochem. 1966; 15: 45-52.
17. Ogawa H, Shiota C, Nishikawa T, Fukushima S, Sasagawa S. Age-related changes in serum concentrations of apolipoprotein A-I, E, and A-IV in SHRSP. J. Hypertens. 1986; 4: 429-31.
18. Ogishima T, Okuda K. An improved method for assay of cholesterol 7α-hydroxylase activity. Anal. Biochem. 1986; 158: 228-32.
19. Kamisako T, Ogawa H. Effect of obstructive jaundice on the regulation of hepatic cholesterol metabolism in the rat. Disappearance of abcg5 and abcg8 mRNA after bile duct ligation. Hepatol. Res. 2003; 25: 99-104.
20. Wetterau JR, Lin MC, Jamil H. Microsomal triglyceride transfer protein. Biochim. Biophys. Acta 1997; 1345: 136-50.
21. Kinnunen PKJ. Hepatic endothelial lipase. In: Borgström B, Brockman HL (eds). Lipases. Elsevier/North-Holland Biomedical Press, Amsterdam. 1984; 307-28.
22. Rodwell VW, Nordstrom JL, Mitschelen JJ. Regulation of HMG-CoA reductase. Adv. Lipid Res. 1976; 14: 1-74.
23. Osumi T, Hashimoto T. Acyl-CoA oxidase of rat liver: A new enzyme for fatty acid oxidation. Biochem. Biophys. Res. Commun. 1978; 83: 479-85.
24. Suzuki H, Kawarabayasi Y, Kondo J et al. Structure and regulation of rat long-chain acyl-CoA synthetase. J. Biol. Chem. 1990; 265: 8681-5.
25. Beck KF, Schreglmann R, Stathopulos I, Klein H, Hoch J, Schweizer M. The fatty acid synthase (FAS) gene and its promoter in Rattus norvegicus. DNA Seq. 1992; 2: 359-86.
26. Desvergne B, Wahli W. Peroxisome proliferator-activated receptor: Nuclear control of metabolism. Endocr. Rev. 2000; 20: 649-88.
27. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell Biol. 1993; 13: 4753-9.
28. Brown MS, Goldstein JL. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell 1975; 6: 307-16.
29. Venkateswaran A, Laffitte BA, Joseph SB et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc. Natl Acad. Sci. USA 2000; 97: 12 097-102.