Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies

PLoS ONE

Volumn 4, Issue 8, 2009, Pages

  Jiang, George ^a,b   Shi, Meng ^a   Conteh, Solomon ^a   Richie, Nancy ^a   Banania, Glenna ^a   Geneshan, Harini ^a   Valencia, Anais ^a   Singh, Priti ^a   Aguiar, Joao ^a   Limbach, Keith ^a   Kamrud, Kurt ^c   Rayner, Jonathan ^c   Smith, Jonathan ^c   Bruder, Joseph T ^d   King, C Richter ^d   Tsuboi, Takafumi ^e   Takeo, Satoru ^e   Endo, Yaeta ^e   Doolan, Denise L ^f   Richie, Thomas L ^a   Weiss, Walter R ^a,b,e   more..

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c AlphaVax Inc   (United States)

^d GenVec   (United States)

^e EHIME UNIVERSITY   (Japan)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA VIRUS VECTOR; APICAL MEMBRANE ANTIGEN 1; CIRCUMSPOROZOITE PROTEIN; CYTOKINE; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 1; PARASITE ANTIGEN; PK4 ANTIGEN; PLASMID DNA; PLASMID VECTOR; POXVIRUS VECTOR; PROTOZOAL VACCINE; SPOROZOITE SURFACE PROTEIN 2; UNCLASSIFIED DRUG; VIRUS VECTOR; PROTOZOON ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IMMUNOGENICITY; INFECTION PREVENTION; INTERMETHOD COMPARISON; MALARIA; MALE; NONHUMAN; PARASITEMIA; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM KNOWLESI; PLASMODIUM KNOWLESI INFECTION; PROTEIN EXPRESSION; REPLICON; RHESUS MONKEY; SPOROZOITE; VACCINATION; VIRAL GENE DELIVERY SYSTEM; VIRUS ATTENUATION; ANIMAL; ANIMAL DISEASE; BIOSYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE VECTOR; GENETICS; IMMUNOLOGY; MACACA; PARASITOLOGY; T LYMPHOCYTE; VIRUS;

ADENOVIRIDAE; ALPHAVIRUS; MACACA MULATTA; PLASMODIUM KNOWLESI; POXVIRIDAE; RODENTIA;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; MACACA MULATTA; MALARIA; MALARIA VACCINES; PLASMODIUM KNOWLESI; T-LYMPHOCYTES; VIRUSES;

EID: 68749104609     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006559     Document Type: Article

References (39)

1. World Malaria Report 2008. World Health Organization.
2. Bojang KA (2006) RTS,S/AS02A for malaria. Expert Rev Vaccines 5: 611-615.
3. Pombo D, Lawrence G, Hirunpetcharat C, Rzepczyk C, Bryden M, et al. (2002) Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet 360: 610.
4. Hoffman SL, Goh LM, Luke TC, Schneider I, Le TP, et al. (2002) Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J Infect Dis 185: 1155-1164.
5. Tarun AS, Dumpit RF, Camargo N, Labaied M, Liu P, et al. (2007) Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. J Infect Dis 196: 608-616.
6. Wykes M, Good MF (2007) A case for whole-parasite malaria vaccines. Int J Parasitol 37: 705-712.
7. Mueller AK, Deckert M, Heiss K, Goetz K, Matuschewski K, et al. (2007) Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells. Am J Pathol 171: 107-115.
8. Druilhe P, Barnwell JW (2007) Pre-erythrocytic stage malaria vaccines: time for a change in path. Curr Opin Microbiol 10: 371-378.
9. Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, et al. (2006) The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature 444: 937-940.
10. Perlaza BL, Valencia AZ, Zapata C, Castellanos A, Sauzet JP, et al. (2008) Protection against Plasmodium falciparum challenge induced in Aotus monkeys by liver-stage antigen-3-derived long synthetic peptides. Eur J Immunol 38: 2610-2615.
11. Perlaza BL, Zapata C, Valencia AZ, Hurtado S, Quintero G, et al. (2003) Immunogenicity and protective efficacy of Plasmodium falciparum liver-stage Ag-3 in Aotus lemurinus griseimembra monkeys. Eur J Immunol 33: 1321-1327.
12. Zapata JC, Perlaza BL, Hurtado S, Quintero GE, Jurado D, et al. (2002) Reproducible infection of intact Aotus lemurinus griseimembra monkeys by Plasmodium falciparum sporozoite inoculation. J Parasitol 88: 723-729.
13. G.Robert Coatney WEC, McWilson Warren, Peter G Contacos (1971) The Primate Malarias. Bethesda: U.S. DEPARMENT OF HEALTH, EDUCATION, AND WELFARE. 366 p.
14. Vythilingam I, Tan CH, Asmad M, Chan ST, Lee KS, et al. (2006) Natural transmission of Plasmodium knowlesi to humans by Anopheles latens in Sarawak, Malaysia. Trans R Soc Trop Med Hyg 100: 1087-1088.
15. Cox-Singh J, Davis TM, Lee KS, Shamsul SS, Matusop A, et al. (2008) Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening. Clin Infect Dis 46: 165-171.
16. Barnwell JW, Howard RJ, Coon HG, Miller LH (1983) Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malaria. Infect Immun 40: 985-994.
17. Rogers WO, Baird JK, Kumar A, Tine JA, Weiss W, et al. (2001) Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infect Immun 69: 5565-5572.
18. Rogers WO, Weiss WR, Kumar A, Aguiar JC, Tine JA, et al. (2002) Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen. Infect Immun 70: 4329-4335.
19. Weiss WR, Kumar A, Jiang G, Williams J, Bostick A, et al. (2007) Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens. PLoS ONE 2: e1063.
20. Rayner JO, Dryga SA, Kamrud KI (2002) Alphavirus vectors and vaccination. Rev Med Virol 12: 279-296.
21. Hubby B, Talarico T, Maughan M, Reap EA, Berglund P, et al. (2007) Development and preclinical evaluation of an alphavirus replicon vaccine for influenza. Vaccine 25: 8180-8189.
22. Li S, Locke E, Bruder J, Clarke D, Doolan DL, et al. (2007) Viral vectors for malaria vaccine development. Vaccine 25: 2567-2574.
23. Earle WC, Perez M (1932) Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17: 1124-1130.
24. Charoenvit Y, Leef ML, Yuan LF, Sedegah M, Beaudoin RL (1987) Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens. Infect Immun 55: 604-608.
25. Madin K, Sawasaki T, Ogasawara T, Endo Y (2000) A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomes. Proc Natl Acad Sci U S A 97: 559-564.
26. Sawasaki T, Hasegawa Y, Tsuchimochi M, Kamura N, Ogasawara T, et al. (2002) A bilayer cell-free protein synthesis system for high-throughput screening of gene products. FEBS Lett 514: 102-105.
27. Sawasaki T, Gouda MD, Kawasaki T, Tsuboi T, Tozawa Y, et al. (2005) The wheat germ cell-free expression system: methods for high-throughput materialization of genetic information. Methods Mol Biol 310: 131-144.
28. Kumar A, Weiss W, Tine JA, Hoffman SL, Rogers WO (2001) ELISPOT assay for detection of peptide specific interferon-gamma secreting cells in rhesus macaques. J Immunol Methods 247: 49-60.
29. Jiang G, Charoenvit Y, Moreno A, Baraceros MF, Banania G, et al. (2007) Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malar J 6: 135.
30. Voller A, Rossan RN (1969) Immunological studies on simian malaria. III. Immunity to challenge and antigenic variation in P. knowlesi. Trans R Soc Trop Med Hyg 63: 507-523.
31. Silvie O, Franetich JF, Charrin S, Mueller MS, Siau A, et al. (2004) A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. J Biol Chem 279: 9490-9496.
32. Brice GT, Dobano C, Sedegah M, Stefaniak M, Graber NL, et al. (2007) Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes Infect 9: 1439-1446.
33. Stahl-Hennig C, Suh YS, Park KS, Sauermann U, Kim KS, et al. (2007) Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of Chinese and Indian origins. J Med Primatol 36: 195-205.
34. Krzych U, Schwenk J (2005) The dissection of CD8 T cells during liver-stage infection. Curr Top Microbiol Immunol 297: 1-24.
35. Schofield L, Villaquiran J, Ferreira A, Schellekens H, Nussenzweig RS, et al. (1987) Gamma-interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature 330: 664-666.
36. + T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Sci USA 85: 573-576.
37. Jobe O, Lumsden J, Mueller AK, Williams J, Silva-Rivera H, et al. (2007) Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells. J Infect Dis 196: 599-607.
38. Stewart VA, McGrath SM, Dubois PM, Pau MG, Mettens P, et al. (2007) Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone. Infect Immun 75: 2283-2290.
39. Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA (2005) Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol 174: 7676-7683.