Protection against Plasmodium falciparum challenge induced in Aotus monkeys by liver-stage antigen-3- derived long synthetic peptides

European Journal of Immunology

Volumn 38, Issue 9, 2008, Pages 2610-2615

  Perlaxa, Blanca Liliana ^a,b   Valencia, Anais Zully ^a   Zapata, Constanza ^a   Castellanos, Angélica ^a,d   Sauzet, Jean Pierre ^b   Blanc, Catherine ^b   Cohen, Joe ^e   Arévalo Herrera, Myriam ^a,d   Corradin, Giampietro ^c   Herrera, Sócrates ^a,d   Druilhe, Pierre ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d Malaria Vaccine and Drug Development Center   (Colombia)

^e GSK   (Belgium)

Author keywords

Aotus monkeys; Immune response; Long synthetic peptides; Malaria pre erythrocytic stage; Malaria vaccine

Indexed keywords

FANSIDAR; IMMUNOLOGICAL ADJUVANT; LIVER STAGE ANTIGEN 3; MALARIA VACCINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; GAMMA INTERFERON; LIVER STAGE SPECIFIC ANTIGEN, PLASMODIUM; LIVER STAGE-SPECIFIC ANTIGEN, PLASMODIUM; PARASITE ANTIGEN; PEPTIDE; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY;

ADULT ANIMAL; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; AOTUS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; EFFECTOR CELL; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; LIVER; MALARIA; MALE; MONKEY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPOROZOITE; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BLOOD; IMMUNOLOGY; MALARIA FALCIPARUM; PARASITOLOGY;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; AOTIDAE; IMMUNIZATION; INTERFERON TYPE II; MALARIA VACCINES; MALARIA, FALCIPARUM; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 50549103953     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200738055     Document Type: Article

References (16)

1. Hoffman, S. L., Goh, L. M., Luke, T. C., Schneider, I., Le, T. P., Doolan, D. L., Sacci, J. et al., Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 2002. 185: 1155-1164.
2. Druilhe, P., Rénia, L. and Fidock, D., Immunity to liver stages. In: Sherman, I. (Ed.) Malaria: Parasite Biology, Pathogenesis and Protection. AMS Press, Washington DC 1998, pp 513-543.
3. Daubersies, P., Thomas, A. W., Millet, P., Brahimi, K., Langermans, J. A., Ollomo, B., BenMohamed, L. et al., Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nat. Med. 2000. 6: 1258-1263.
4. Perlaza, B. L., Zapata, C., Valencia, A. Z., Hurtado, S., Quintero, G., Sauzet, J. P., Brahimi, K. et al., Immunogenicity and protective efficacy of Plasmodium falciparum liver-stage Ag-3 in Aotus lemurinus griseimembra monkeys. Eur. J. Immunol. 2003. 33: 1321-1327.
5. Perlaza, B. L., Sauzet, J. P., Toure-Balde, A., Brahimi, K., Daubersies, P., Corradin, G. and Druilhe, P., Long synthetic peptides encompassing the P. falciparum LSA3 are the target of human B and T cells and are potent inducers of B-fielper, T-helper and cytolytic T cell responses in mice. Eur. J. Immunol. 2001. 7: 2200-2209.
6. Corradin, G., Spertini, F. and Verdini, A., Medicinal application of long synthetic peptide technology. Expert Opin. Biol. Ther. 2004. 4: 1629-1639.
7. Sauzet, J. P., Perlaza, B. L., Daubersies, P., Brahimi, K. and Druflhe, P., DNA immunization by P. falciparum LSA-3 induces protection against a P. yoelii sporozoite challenge. Infect. Immun. 2001. 69: 1202-1206.
8. Mellouk, S., Maheshwari, R. K., Rhodes-Feuillette, A., Beaudoin, R. L., Berbiguier, N., Matile, H., Miltgen, F. et al., Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures. J. Immunol. 1987. 139: 4192-4195.
9. + T cells and antibodies required for immunity to malaria sporozoites. Nature 1987. 330: 664-666.
10. BenMohamed, L., Gras-Masse, H., Tartar, A., Daubersies, P., Brahimi, K., Bossus, M., Thomas, A. and Druilhe, P., Lipopeptide immunization without adjuvant induces potent and long- lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. Eur. J. Immunol. 1997. 27: 1242-1253.
11. Perlaza, B. L., Arevalo-Herrera, M., Brahimi, K., Quintero, G., Palomino, J. C., Gras-Masse, H., Tartar, A. et al., Immunogenicity of four Plasmodium falciparum preerythrocytic antigens in Aotus lemurinus monkeys. Infect. Immun. 1998. 66: 3423-3428.
12. Zapata, J. C., Perlaza, B. L., Hurtado, S., Quintero, G. E., Jurado, D., Gonzalez, L, Druilhe, P. et al., Reproducible infection of intact Aotus lemurinus griseimembra monkeys by Plasmodium falciparum sporozoite inoculation. J. Parasitol. 2002. 88: 723-729.
13. Bottius, E., BenMohamed, L., Brahimi, K., Gras, H., Lepers, J. P., Raharimalada, L., Aikawa, M. et al., A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. J. Immunol. 1996. 156: 2874-2884.
14. Collins, W. E., Galland, G. G., Sullivan, J. S., Morris, C. L., Richardson, B. B. and Roberts, J. M., The Santa Lucia strain of Plasmodium falciparum as a model for vaccine studies. I. Development in Aotus lemurinus griseimembra monkeys. Am J. Trop. Med. Hyg. 1996. 54: 372-379.
15. Druilhe, P., Moreno, A., Blanc, C., Brasseur, P. H. and Jacquier, P., A colorimetric in vitro drug sensitivity assay for Plasmodium falciparum based on a highly sensitive double-site lactate dehydrogenase antigen-capture enzyme-linked immunosorbent assay. Am. J. Trop. Med. Hyg. 2001. 64: 233-241.
16. Druilhe, P., Brasseur, P., Blanc, C. and Makler, M., Improved assessment of Plasmodium vivax response to antimalarial drugs by a colorimetric double-site plasmodium. lactate dehydrogenase antigen capture enzyme-linked immunosorbent assay. Antimicrob. Agents Chemother. 2007. 51: 2112-2116.