Effect of compound plate composition on measurement of hERG current IC50 using PatchXpress

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 1, 2009, Pages 39-44

  Mo, Zun Li ^a   Faxel, Tracy ^a   Yang, Young Sun ^a   Gallavan, Robert ^a   Messing, Dean ^a   Bahinski, Anthony ^a  

^a PFIZER INC   (United States)

Author keywords

cLogP; Compound plate adsorption; HEK293; hERG; Incubation time; PatchXpress

Indexed keywords

BEPRIDIL; CISAPRIDE; DOFETILIDE; GLASS; POLYSTYRENE; POTASSIUM CHANNEL HERG; SOTALOL;

ADSORPTION; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IC 50; INCUBATION TIME; PATCH CLAMP; POTASSIUM CURRENT; PROTEIN EXPRESSION;

ADSORPTION; BEPRIDIL; CELL LINE; CISAPRIDE; ETHER-A-GO-GO POTASSIUM CHANNELS; GLASS; HUMANS; HYDROPHOBICITY; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; POLYSTYRENES; REPRODUCIBILITY OF RESULTS; SOTALOL; SULFONAMIDES;

EID: 68749093821     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.04.198     Document Type: Article

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